SOX6: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Transcription factor SOX-6''' is a [[protein]] that in humans is encoded by the ''SOX6'' [[gene]].<ref name="pmid11255018">{{cite journal | vauthors = Cohen-Barak O, Hagiwara N, Arlt MF, Horton JP, Brilliant MH | title = Cloning, characterization and chromosome mapping of the human SOX6 gene | journal = Gene | volume = 265 | issue = 1-2 | pages = 157–64 | date = Mar 2001 | pmid = 11255018 | pmc =  | doi = 10.1016/S0378-1119(01)00346-8 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SOX6 SRY (sex determining region Y)-box 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55553| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_SOX6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1i11.
| PDB = {{PDB2|1i11}}
| Name = SRY (sex determining region Y)-box 6
| HGNCid = 16421
| Symbol = SOX6
| AltSymbols =; HSSOX6
| OMIM = 607257
| ECnumber = 
| Homologene = 22631
| MGIid = 98368
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006325 |text = establishment and/or maintenance of chromatin architecture}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0035051 |text = cardiac cell differentiation}} {{GNF_GO|id=GO:0042692 |text = muscle cell differentiation}} {{GNF_GO|id=GO:0045165 |text = cell fate commitment}} {{GNF_GO|id=GO:0051216 |text = cartilage development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55553
    | Hs_Ensembl = ENSG00000110693
    | Hs_RefseqProtein = NP_059978
    | Hs_RefseqmRNA = NM_017508
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 15948371
    | Hs_GenLoc_end = 16454494
    | Hs_Uniprot = P35712
    | Mm_EntrezGene = 20679
    | Mm_Ensembl = ENSMUSG00000051910
    | Mm_RefseqmRNA = NM_001025560
    | Mm_RefseqProtein = NP_001020731
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 115262493
    | Mm_GenLoc_end = 115786235
    | Mm_Uniprot = Q3V1J7
  }}
}}
'''SRY (sex determining region Y)-box 6''', also known as '''SOX6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SOX6 SRY (sex determining region Y)-box 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55553| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor groove of DNA, causing a 70- to 85-degree bend and introducing local conformational changes.[supplied by OMIM]<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor groove of DNA, causing a 70- to 85-degree bend and introducing local conformational changes.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SOX6 SRY (sex determining region Y)-box 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55553| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
SOX6 has been shown to [[Protein-protein interaction|interact]] with [[CTBP2]]<ref name="pmid11504872">{{cite journal | vauthors = Murakami A, Ishida S, Thurlow J, Revest JM, Dickson C | title = SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter | journal = Nucleic Acids Research | volume = 29 | issue = 16 | pages = 3347–55 | date = Aug 2001 | pmid = 11504872 | pmc = 55854 | doi = 10.1093/nar/29.16.3347 }}</ref> and [[CENPK]].<ref name="pmid10996314">{{cite journal | vauthors = Yamashita A, Ito M, Takamatsu N, Shiba T | title = Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis | journal = FEBS Letters | volume = 481 | issue = 2 | pages = 147–51 | date = Sep 2000 | pmid = 10996314 | doi = 10.1016/S0014-5793(00)01987-6 }}</ref>
 
It has also been demonstrated that SOX6 protein accumulates in the differentiating human erythrocytes, and then is able to downregulate its own transcription, by directly binding to an evolutionarily conserved consensus sequences located near ''SOX6'' transcriptional start site.<ref name="pmid20852263">{{cite journal | vauthors = Cantu' C, Grande V, Alborelli I, Cassinelli L, Cantu' I, Colzani MT, Ierardi R, Ronzoni L, Cappellini MD, Ferrari G, Ottolenghi S, Ronchi A | title = A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells | journal = Nucleic Acids Research | volume = 39 | issue = 2 | pages = 486–501 | date = Jan 2011 | pmid = 20852263 | pmc = 3025548 | doi = 10.1093/nar/gkq819 }}</ref>
 
Sox6 appears to have a crucial role in the transcriptional regulation of globin genes, and in directing the terminal differentiation of red blood cells.<ref>{{cite journal | vauthors = Cantù C, Ierardi R, Alborelli I, Fugazza C, Cassinelli L, Piconese S, Bosè F, Ottolenghi S, Ferrari G, Ronchi A | title = Sox6 enhances erythroid differentiation in human erythroid progenitors | journal = Blood | volume = 117 | issue = 13 | pages = 3669–79 | date = Mar 2011 | doi = 10.1182/blood-2010-04-282350 | pmid = 21263153 }}</ref>
 
== See also ==
* [[SOX genes]]
* [[SOX genes]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A | title = A conserved family of genes related to the testis determining gene, SRY | journal = Nucleic Acids Research | volume = 20 | issue = 11 | pages = 2887 | date = Jun 1992 | pmid = 1614875 | pmc = 336939 | doi = 10.1093/nar/20.11.2887 }}
| citations =
* {{cite journal | vauthors = Lefebvre V, Li P, de Crombrugghe B | title = A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene | journal = The EMBO Journal | volume = 17 | issue = 19 | pages = 5718–33 | date = Oct 1998 | pmid = 9755172 | pmc = 1170900 | doi = 10.1093/emboj/17.19.5718 }}
*{{cite journal | author=Denny P, Swift S, Brand N, ''et al.'' |title=A conserved family of genes related to the testis determining gene, SRY. |journal=Nucleic Acids Res. |volume=20 |issue= 11 |pages= 2887 |year= 1992 |pmid= 1614875 |doi= }}
* {{cite journal | vauthors = Hagiwara N, Klewer SE, Samson RA, Erickson DT, Lyon MF, Brilliant MH | title = Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 8 | pages = 4180–5 | date = Apr 2000 | pmid = 10760285 | pmc = 18189 | doi = 10.1073/pnas.97.8.4180 }}
*{{cite journal | author=Lefebvre V, Li P, de Crombrugghe B |title=A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. |journal=EMBO J. |volume=17 |issue= 19 |pages= 5718-33 |year= 1998 |pmid= 9755172 |doi= 10.1093/emboj/17.19.5718 }}
* {{cite journal | vauthors = Yamashita A, Ito M, Takamatsu N, Shiba T | title = Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis | journal = FEBS Letters | volume = 481 | issue = 2 | pages = 147–51 | date = Sep 2000 | pmid = 10996314 | doi = 10.1016/S0014-5793(00)01987-6 }}
*{{cite journal | author=Hagiwara N, Klewer SE, Samson RA, ''et al.'' |title=Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 4180-5 |year= 2000 |pmid= 10760285 |doi= }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Yamashita A, Ito M, Takamatsu N, Shiba T |title=Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis. |journal=FEBS Lett. |volume=481 |issue= 2 |pages= 147-51 |year= 2000 |pmid= 10996314 |doi= }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Murakami A, Ishida S, Thurlow J, Revest JM, Dickson C | title = SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter | journal = Nucleic Acids Research | volume = 29 | issue = 16 | pages = 3347–55 | date = Aug 2001 | pmid = 11504872 | pmc = 55854 | doi = 10.1093/nar/29.16.3347 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Cohen-Barak O, Yi Z, Hagiwara N, Monzen K, Komuro I, Brilliant MH | title = Sox6 regulation of cardiac myocyte development | journal = Nucleic Acids Research | volume = 31 | issue = 20 | pages = 5941–8 | date = Oct 2003 | pmid = 14530442 | pmc = 219484 | doi = 10.1093/nar/gkg807 }}
*{{cite journal  | author=Cohen-Barak O, Hagiwara N, Arlt MF, ''et al.'' |title=Cloning, characterization and chromosome mapping of the human SOX6 gene. |journal=Gene |volume=265 |issue= 1-2 |pages= 157-64 |year= 2001 |pmid= 11255018 |doi=  }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal | author=Murakami A, Ishida S, Thurlow J, ''et al.'' |title=SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter. |journal=Nucleic Acids Res. |volume=29 |issue= 16 |pages= 3347-55 |year= 2001 |pmid= 11504872 |doi=  }}
* {{cite journal | vauthors = Ueda R, Yoshida K, Kawakami Y, Kawase T, Toda M | title = Expression of a transcriptional factor, SOX6, in human gliomas | journal = Brain Tumor Pathology | volume = 21 | issue = 1 | pages = 35–8 | year = 2005 | pmid = 15696967 | doi = 10.1007/BF02482175 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ueda R, Yoshida K, Kawakami Y, Kawase T, Toda M | title = Immunohistochemical analysis of SOX6 expression in human brain tumors | journal = Brain Tumor Pathology | volume = 21 | issue = 3 | pages = 117–20 | year = 2005 | pmid = 15696972 | doi = 10.1007/BF02482186 }}
*{{cite journal | author=Cohen-Barak O, Yi Z, Hagiwara N, ''et al.'' |title=Sox6 regulation of cardiac myocyte development. |journal=Nucleic Acids Res. |volume=31 |issue= 20 |pages= 5941-8 |year= 2004 |pmid= 14530442 |doi=  }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-8 | date = Jan 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Fernández-Lloris R, Osses N, Jaffray E, Shen LN, Vaughan OA, Girwood D, Bartrons R, Rosa JL, Hay RT, Ventura F | title = Repression of SOX6 transcriptional activity by SUMO modification | journal = FEBS Letters | volume = 580 | issue = 5 | pages = 1215–21 | date = Feb 2006 | pmid = 16442531 | doi = 10.1016/j.febslet.2006.01.031 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
* {{cite journal | vauthors = Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, Moro T, Nakamura K, Kawaguchi H, Chung UI | title = Identification and characterization of the human SOX6 promoter | journal = Biochemical and Biophysical Research Communications | volume = 357 | issue = 2 | pages = 383–90 | date = Jun 2007 | pmid = 17433257 | doi = 10.1016/j.bbrc.2007.03.133 }}
*{{cite journal | author=Ueda R, Yoshida K, Kawakami Y, ''et al.'' |title=Expression of a transcriptional factor, SOX6, in human gliomas. |journal=Brain tumor pathology |volume=21 |issue= 1 |pages= 35-8 |year= 2005 |pmid= 15696967 |doi= }}
*{{cite journal | author=Ueda R, Yoshida K, Kawakami Y, ''et al.'' |title=Immunohistochemical analysis of SOX6 expression in human brain tumors. |journal=Brain tumor pathology |volume=21 |issue= 3 |pages= 117-20 |year= 2005 |pmid= 15696972 |doi= }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Fernández-Lloris R, Osses N, Jaffray E, ''et al.'' |title=Repression of SOX6 transcriptional activity by SUMO modification. |journal=FEBS Lett. |volume=580 |issue= 5 |pages= 1215-21 |year= 2006 |pmid= 16442531 |doi= 10.1016/j.febslet.2006.01.031 }}
*{{cite journal | author=Ikeda T, Saito T, Ushita M, ''et al.'' |title=Identification and characterization of the human SOX6 promoter. |journal=Biochem. Biophys. Res. Commun. |volume=357 |issue= 2 |pages= 383-90 |year= 2007 |pmid= 17433257 |doi= 10.1016/j.bbrc.2007.03.133 }}
}}
{{refend}}
{{refend}}


Line 86: Line 41:
* {{MeshName|SOX6+protein,+human}}
* {{MeshName|SOX6+protein,+human}}


{{NLM content}}
{{PDB Gallery|geneid=55553}}
{{Transcription factors|g4}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]


[[fr:SOX6]]
 
{{WikiDoc Sources}}
{{gene-11-stub}}

Latest revision as of 06:51, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription factor SOX-6 is a protein that in humans is encoded by the SOX6 gene.[1][2]

Function

The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor groove of DNA, causing a 70- to 85-degree bend and introducing local conformational changes.[supplied by OMIM][2]

Interactions

SOX6 has been shown to interact with CTBP2[3] and CENPK.[4]

It has also been demonstrated that SOX6 protein accumulates in the differentiating human erythrocytes, and then is able to downregulate its own transcription, by directly binding to an evolutionarily conserved consensus sequences located near SOX6 transcriptional start site.[5]

Sox6 appears to have a crucial role in the transcriptional regulation of globin genes, and in directing the terminal differentiation of red blood cells.[6]

See also

References

  1. ↑ Cohen-Barak O, Hagiwara N, Arlt MF, Horton JP, Brilliant MH (Mar 2001). "Cloning, characterization and chromosome mapping of the human SOX6 gene". Gene. 265 (1–2): 157–64. doi:10.1016/S0378-1119(01)00346-8. PMID 11255018.
  2. ↑ 2.0 2.1 "Entrez Gene: SOX6 SRY (sex determining region Y)-box 6".
  3. ↑ Murakami A, Ishida S, Thurlow J, Revest JM, Dickson C (Aug 2001). "SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter". Nucleic Acids Research. 29 (16): 3347–55. doi:10.1093/nar/29.16.3347. PMC 55854. PMID 11504872.
  4. ↑ Yamashita A, Ito M, Takamatsu N, Shiba T (Sep 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Letters. 481 (2): 147–51. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314.
  5. ↑ Cantu' C, Grande V, Alborelli I, Cassinelli L, Cantu' I, Colzani MT, Ierardi R, Ronzoni L, Cappellini MD, Ferrari G, Ottolenghi S, Ronchi A (Jan 2011). "A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells". Nucleic Acids Research. 39 (2): 486–501. doi:10.1093/nar/gkq819. PMC 3025548. PMID 20852263.
  6. ↑ Cantù C, Ierardi R, Alborelli I, Fugazza C, Cassinelli L, Piconese S, Bosè F, Ottolenghi S, Ferrari G, Ronchi A (Mar 2011). "Sox6 enhances erythroid differentiation in human erythroid progenitors". Blood. 117 (13): 3669–79. doi:10.1182/blood-2010-04-282350. PMID 21263153.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=SOX6&oldid=1415449"