SOCS5: Difference between revisions

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Latest revision as of 20:15, 20 February 2018

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene.^[1]^[2]^[3]

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.^[3]

References

↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
↑ ^3.0 ^3.1 "Entrez Gene: SOCS5 suppressor of cytokine signaling 5".

Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
Wang J, Campbell IL (2002). "Cytokine signaling in the brain: putting a SOCS in it?". J. Neurosci. Res. 67 (4): 423–7. doi:10.1002/jnr.10145. PMID 11835308.
Krebs DL, Hilton DJ (2001). "SOCS proteins: negative regulators of cytokine signaling". Stem Cells. 19 (5): 378–87. doi:10.1634/stemcells.19-5-378. PMID 11553846.
Ozaki A, Seki Y, Fukushima A, Kubo M (2005). "The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model". J. Immunol. 175 (8): 5489–97. doi:10.4049/jimmunol.175.8.5489. PMID 16210657.
Kario E, Marmor MD, Adamsky K, et al. (2005). "Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling". J. Biol. Chem. 280 (8): 7038–48. doi:10.1074/jbc.M408575200. PMID 15590694.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bayle J, Letard S, Frank R, et al. (2004). "Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling". J. Biol. Chem. 279 (13): 12249–59. doi:10.1074/jbc.M313381200. PMID 14707129.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Seki Y, Hayashi K, Matsumoto A, et al. (2002). "Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13003–8. doi:10.1073/pnas.202477099. PMC 130576. PMID 12242343.
Magrangeas F, Apiou F, Denis S, et al. (2000). "Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization". Cytogenet. Cell Genet. 88 (1–2): 78–81. doi:10.1159/000015490. PMID 10773671.
Hilton DJ, Richardson RT, Alexander WS, et al. (1998). "Twenty proteins containing a C-terminal SOCS box form five structural classes". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 114–9. doi:10.1073/pnas.95.1.114. PMC 18144. PMID 9419338.

This protein-related article is a stub. You can help Wikipedia by expanding it.

[pmid9734811-1] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[pmid11230166-2] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-3] 3.0 ^3.1 "Entrez Gene: SOCS5 suppressor of cytokine signaling 5".

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[2]

[3]

@@ Line 1: / Line 1: @@
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+'''Suppressor of cytokine signaling 5''' is a [[protein]] that in humans is encoded by the ''SOCS5'' [[gene]].<ref name="pmid9734811">{{cite journal | vauthors = Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 3 | pages = 169–76 |date=Dec 1998 | pmid = 9734811 | pmc =  | doi =10.1093/dnares/5.3.169  }}</ref><ref name="pmid11230166">{{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs | journal = Genome Res | volume = 11 | issue = 3 | pages = 422–35 |date=Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}</ref><ref name="entrez"/>
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- | image =
- | image_source =
- | PDB =
- | Name = Suppressor of cytokine signaling 5
- | HGNCid = 16852
- | Symbol = SOCS5
- | AltSymbols =; CIS6; CISH6; Cish5; KIAA0671; SOCS-5
- | OMIM = 607094
- | ECnumber =
- | Homologene = 10495
- | MGIid = 2385459
- | Function = {{GNF_GO|id=GO:0005154 |text = epidermal growth factor receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0019210 |text = kinase inhibitor activity}}
-  | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
-  | Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007259 |text = JAK-STAT cascade}} {{GNF_GO|id=GO:0009968 |text = negative regulation of signal transduction}} {{GNF_GO|id=GO:0019221 |text = cytokine and chemokine mediated signaling pathway}} {{GNF_GO|id=GO:0045627 |text = positive regulation of T-helper 1 cell differentiation}} {{GNF_GO|id=GO:0045629 |text = negative regulation of T-helper 2 cell differentiation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 9655
-    | Hs_Ensembl =
-    | Hs_RefseqProtein = NP_054730
-    | Hs_RefseqmRNA = NM_014011
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr =
-    | Hs_GenLoc_start =
-    | Hs_GenLoc_end =
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 56468
-    | Mm_Ensembl = ENSMUSG00000037104
-    | Mm_RefseqmRNA = NM_019654
-    | Mm_RefseqProtein = NP_062628
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 17
-    | Mm_GenLoc_start = 87016005
-    | Mm_GenLoc_end = 87045911
-    | Mm_Uniprot = Q3UXZ1
-  }}
-}}
-'''Suppressor of cytokine signaling 5''', also known as '''SOCS5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SOCS5 suppressor of cytokine signaling 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9655| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: SOCS5 suppressor of cytokine signaling 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9655| accessdate = }}</ref>
+| summary_text = The protein encoded by this gene contains a [[SH2 domain]] and a SOCS BOX domain. The protein thus belongs to the [[SOCS|suppressor of cytokine signaling]] (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible [[Negative regulation|negative regulators]] of [[cytokine]] signaling. The specific function of this protein has not yet been determined. Two alternatively spliced [[transcript variants]] encoding an identical protein have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: SOCS5 suppressor of cytokine signaling 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9655| accessdate = }}</ref>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Kile BT, Schulman BA, Alexander WS, ''et al.'' |title=The SOCS box: a tale of destruction and degradation. |journal=Trends Biochem. Sci. |volume=27 |issue= 5 |pages= 235-41 |year= 2002 |pmid= 12076535 |doi=  }}
+*{{cite journal   |vauthors=Kile BT, Schulman BA, Alexander WS, etal |title=The SOCS box: a tale of destruction and degradation |journal=Trends Biochem. Sci. |volume=27 |issue= 5 |pages= 235–41 |year= 2002 |pmid= 12076535 |doi=10.1016/S0968-0004(02)02085-6  }}
-*{{cite journal  | author=Wang J, Campbell IL |title=Cytokine signaling in the brain: putting a SOCS in it? |journal=J. Neurosci. Res. |volume=67 |issue= 4 |pages= 423-7 |year= 2002 |pmid= 11835308 |doi=  }}
+*{{cite journal  | vauthors=Wang J, Campbell IL |title=Cytokine signaling in the brain: putting a SOCS in it? |journal=J. Neurosci. Res. |volume=67 |issue= 4 |pages= 423–7 |year= 2002 |pmid= 11835308 |doi=10.1002/jnr.10145  }}
-*{{cite journal  | author=Krebs DL, Hilton DJ |title=SOCS proteins: negative regulators of cytokine signaling. |journal=Stem Cells |volume=19 |issue= 5 |pages= 378-87 |year= 2001 |pmid= 11553846 |doi=  }}
+*{{cite journal  | vauthors=Krebs DL, Hilton DJ |title=SOCS proteins: negative regulators of cytokine signaling |journal=Stem Cells |volume=19 |issue= 5 |pages= 378–87 |year= 2001 |pmid= 11553846 |doi=10.1634/stemcells.19-5-378  }}
-*{{cite journal  | author=Ozaki A, Seki Y, Fukushima A, Kubo M |title=The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model. |journal=J. Immunol. |volume=175 |issue= 8 |pages= 5489-97 |year= 2005 |pmid= 16210657 |doi=  }}
+*{{cite journal  | vauthors=Ozaki A, Seki Y, Fukushima A, Kubo M |title=The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model |journal=J. Immunol. |volume=175 |issue= 8 |pages= 5489–97 |year= 2005 |pmid= 16210657 |doi=  10.4049/jimmunol.175.8.5489}}
-*{{cite journal  | author=Kario E, Marmor MD, Adamsky K, ''et al.'' |title=Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. |journal=J. Biol. Chem. |volume=280 |issue= 8 |pages= 7038-48 |year= 2005 |pmid= 15590694 |doi= 10.1074/jbc.M408575200 }}
+*{{cite journal   |vauthors=Kario E, Marmor MD, Adamsky K, etal |title=Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling |journal=J. Biol. Chem. |volume=280 |issue= 8 |pages= 7038–48 |year= 2005 |pmid= 15590694 |doi= 10.1074/jbc.M408575200 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Bayle J, Letard S, Frank R, ''et al.'' |title=Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12249-59 |year= 2004 |pmid= 14707129 |doi= 10.1074/jbc.M313381200 }}
+*{{cite journal   |vauthors=Bayle J, Letard S, Frank R, etal |title=Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12249–59 |year= 2004 |pmid= 14707129 |doi= 10.1074/jbc.M313381200 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Seki Y, Hayashi K, Matsumoto A, ''et al.'' |title=Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 20 |pages= 13003-8 |year= 2002 |pmid= 12242343 |doi= 10.1073/pnas.202477099 }}
+*{{cite journal   |vauthors=Seki Y, Hayashi K, Matsumoto A, etal |title=Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 20 |pages= 13003–8 |year= 2002 |pmid= 12242343 |doi= 10.1073/pnas.202477099  | pmc=130576 }}
-*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
+*{{cite journal   |vauthors=Magrangeas F, Apiou F, Denis S, etal |title=Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization |journal=Cytogenet. Cell Genet. |volume=88 |issue= 1–2 |pages= 78–81 |year= 2000 |pmid= 10773671 |doi=10.1159/000015490  }}
-*{{cite journal  | author=Magrangeas F, Apiou F, Denis S, ''et al.'' |title=Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 1-2 |pages= 78-81 |year= 2000 |pmid= 10773671 |doi=  }}
+*{{cite journal   |vauthors=Hilton DJ, Richardson RT, Alexander WS, etal |title=Twenty proteins containing a C-terminal SOCS box form five structural classes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 1 |pages= 114–9 |year= 1998 |pmid= 9419338 |doi=10.1073/pnas.95.1.114  | pmc=18144  }}
-*{{cite journal  | author=Ishikawa K, Nagase T, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169-76 |year= 1998 |pmid= 9734811 |doi=  }}
-*{{cite journal  | author=Hilton DJ, Richardson RT, Alexander WS, ''et al.'' |title=Twenty proteins containing a C-terminal SOCS box form five structural classes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 1 |pages= 114-9 |year= 1998 |pmid= 9419338 |doi=  }}
 }}
 {{refend}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
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+}}
+{{JAK-STAT signaling pathway}}
 {{protein-stub}}
-{{WikiDoc Sources}}

SOCS5: Difference between revisions

Latest revision as of 20:15, 20 February 2018

References

Further reading

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