SNRPB

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Small nuclear ribonucleoprotein polypeptides B and B1
File:PBB Protein SNRPB image.jpg
PDB rendering based on 1d3b.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols SNRPB ; SNRPB1; COD; SmB/SmB'; snRNP-B
External IDs Template:OMIM5 Template:MGI HomoloGene: 21719
RNA expression pattern
File:PBB GE SNRPB 208821 at tn.png
File:PBB GE SNRPB 213175 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Small nuclear ribonucleoprotein polypeptides B and B1, also known as SNRPB, is a human gene.[1]

The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: SNRPB small nuclear ribonucleoprotein polypeptides B and B1".

Further reading

  • Will CL, Lührmann R (2001). "Spliceosomal UsnRNP biogenesis, structure and function". Curr. Opin. Cell Biol. 13 (3): 290–301. PMID 11343899.
  • Griffith AJ, Schmauss C, Craft J (1992). "The murine gene encoding the highly conserved Sm B protein contains a nonfunctional alternative 3' splice site". Gene. 114 (2): 195–201. PMID 1376292.
  • Schmauss C, Lerner MR (1990). "The closely related small nuclear ribonucleoprotein polypeptides N and B/B' are distinguishable by antibodies as well as by differences in their mRNAs and gene structures". J. Biol. Chem. 265 (18): 10733–9. PMID 1693924.
  • Elkon KB, Hines JJ, Chu JL, Parnassa A (1990). "Epitope mapping of recombinant HeLa SmB and B' peptides obtained by the polymerase chain reaction". J. Immunol. 145 (2): 636–43. PMID 1694885.
  • Chu JL, Elkon KB (1991). "The small nuclear ribonucleoproteins, SmB and B', are products of a single gene". Gene. 97 (2): 311–2. PMID 1825643.
  • Sharpe NG, Williams DG, Latchman DS (1991). "Regulated expression of the small nuclear ribonucleoprotein particle protein SmN in embryonic stem cell differentiation". Mol. Cell. Biol. 10 (12): 6817–20. PMID 2174118.
  • Schmauss C, McAllister G, Ohosone Y; et al. (1989). "A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'". Nucleic Acids Res. 17 (4): 1733–43. PMID 2522186.
  • Feeney RJ, Sauterer RA, Feeney JL, Zieve GW (1989). "Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles". J. Biol. Chem. 264 (10): 5776–83. PMID 2522439.
  • Ohosone Y, Mimori T, Griffith A; et al. (1989). "Molecular cloning of cDNA encoding Sm autoantigen: derivation of a cDNA for a B polypeptide of the U series of small nuclear ribonucleoprotein particles". Proc. Natl. Acad. Sci. U.S.A. 86 (11): 4249–53. PMID 2524838.
  • van Dam A, Winkel I, Zijlstra-Baalbergen J; et al. (1990). "Cloned human snRNP proteins B and B' differ only in their carboxy-terminal part". EMBO J. 8 (12): 3853–60. PMID 2531083.
  • Huntriss JD, Latchman DS, Williams DG (1993). "Lupus autoantibodies discriminate between the highly homologous Sm polypeptides B/B' and SmN by binding an epitope restricted to B/B'". Clin. Exp. Immunol. 92 (2): 263–7. PMID 7683587.
  • Gerrelli D, Grimaldi K, Horn D; et al. (1993). "The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein". J. Mol. Cell. Cardiol. 25 (3): 321–9. doi:10.1006/jmcc.1993.1038. PMID 8510173.
  • Simons A, Melamed-Bessudo C, Wolkowicz R; et al. (1997). "PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb". Oncogene. 14 (2): 145–55. doi:10.1038/sj.onc.1200825. PMID 9010216.
  • Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. PMID 9323129.
  • Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
  • Bedford MT, Reed R, Leder P (1998). "WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10602–7. PMID 9724750.
  • Kambach C, Walke S, Young R; et al. (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3): 375–87. PMID 10025403.
  • Gray TA, Smithwick MJ, Schaldach MA; et al. (2000). "Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci". Nucleic Acids Res. 27 (23): 4577–84. PMID 10556313.
  • Charroux B, Pellizzoni L, Perkinson RA; et al. (2000). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. PMID 10601333.
  • Charroux B, Pellizzoni L, Perkinson RA; et al. (2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". J. Cell Biol. 148 (6): 1177–86. PMID 10725331.

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