SNAI2
| Snail homolog 2 (Drosophila) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SNAI2 ; MGC10182; SLUG; SLUGH1; WS2D | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 31127 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SNAI2 213139 at tn.png | |||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Snail homolog 2 (Drosophila), also known as SNAI2 or Slug, is a human gene.[1]
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects.[1]
References
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Savagner P, Yamada KM, Thiery JP (1997). "The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition". J. Cell Biol. 137 (6): 1403–19. PMID 9182671.
- Rhim H, Savagner P, Thibaudeau G; et al. (1998). "Localization of a neural crest transcription factor, Slug, to mouse chromosome 16 and human chromosome 8". Mamm. Genome. 8 (11): 872–3. PMID 9337409.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Cohen ME, Yin M, Paznekas WA; et al. (1998). "Human SLUG gene organization, expression, and chromosome map location on 8q". Genomics. 51 (3): 468–71. doi:10.1006/geno.1998.5367. PMID 9721220.
- Stegmann K, Boecker J, Kosan C; et al. (1999). "Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region". Mutat. Res. 406 (2–4): 63–9. PMID 10479723.
- Inukai T, Inoue A, Kurosawa H; et al. (1999). "SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein". Mol. Cell. 4 (3): 343–52. PMID 10518215.
- Hemavathy K, Guru SC, Harris J; et al. (2000). "Human Slug is a repressor that localizes to sites of active transcription". Mol. Cell. Biol. 20 (14): 5087–95. PMID 10866665.
- Hajra KM, Chen DY, Fearon ER (2002). "The SLUG zinc-finger protein represses E-cadherin in breast cancer". Cancer Res. 62 (6): 1613–8. PMID 11912130.
- Sánchez-Martín M, Rodríguez-García A, Pérez-Losada J; et al. (2003). "SLUG (SNAI2) deletions in patients with Waardenburg disease". Hum. Mol. Genet. 11 (25): 3231–6. PMID 12444107.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Kajita M, McClinic KN, Wade PA (2004). "Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress". Mol. Cell. Biol. 24 (17): 7559–66. doi:10.1128/MCB.24.17.7559-7566.2004. PMID 15314165.
- Catalano A, Rodilossi S, Rippo MR; et al. (2004). "Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells". J. Biol. Chem. 279 (45): 46706–14. doi:10.1074/jbc.M406696200. PMID 15337769.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Uchikado Y, Natsugoe S, Okumura H; et al. (2005). "Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma". Clin. Cancer Res. 11 (3): 1174–80. PMID 15709186.
- Tripathi MK, Misra S, Khedkar SV; et al. (2005). "Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells". J. Biol. Chem. 280 (17): 17163–71. doi:10.1074/jbc.M501375200. PMID 15734731.
- Tripathi MK, Misra S, Chaudhuri G (2005). "Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells". Biochem. Biophys. Res. Commun. 329 (2): 508–15. doi:10.1016/j.bbrc.2005.02.006. PMID 15737616.
- Moody SE, Perez D, Pan TC; et al. (2005). "The transcriptional repressor Snail promotes mammary tumor recurrence". Cancer Cell. 8 (3): 197–209. doi:10.1016/j.ccr.2005.07.009. PMID 16169465.
- Chen M, Chen LM, Chai KX (2006). "Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG". Prostate. 66 (9): 911–20. doi:10.1002/pros.20325. PMID 16541421.
- Turner FE, Broad S, Khanim FL; et al. (2006). "Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes". J. Biol. Chem. 281 (30): 21321–31. doi:10.1074/jbc.M509731200. PMID 16707493.
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