SLC5A8: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Sodium-coupled monocarboxylate transporter 1''' is a [[protein]] that in humans is encoded by the ''SLC5A8'' [[gene]].<ref name="pmid12107270">{{cite journal | vauthors = Rodriguez AM, Perron B, Lacroix L, Caillou B, Leblanc G, Schlumberger M, Bidart JM, Pourcher T | title = Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes | journal = J Clin Endocrinol Metab | volume = 87 | issue = 7 | pages = 3500–3 |date=Jul 2002 | pmid = 12107270 | pmc =  | doi =10.1210/jc.87.7.3500 }}</ref><ref name="pmid12829793">{{cite journal | vauthors = Li H, Myeroff L, Smiraglia D, Romero MF, Pretlow TP, Kasturi L, Lutterbaugh J, Rerko RM, Casey G, Issa JP, Willis J, Willson JK, Plass C, Markowitz SD | title = SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers | journal = Proc Natl Acad Sci U S A | volume = 100 | issue = 14 | pages = 8412–7 |date=Jul 2003 | pmid = 12829793 | pmc = 166243 | doi = 10.1073/pnas.1430846100 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC5A8 solute carrier family 5 (iodide transporter), member 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=160728| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 5 (iodide transporter), member 8
| HGNCid = 19119
| Symbol = SLC5A8
| AltSymbols =; AIT; MGC125354; SMCT
| OMIM = 608044
| ECnumber =
| Homologene = 64832
| MGIid = 2384916
  | GeneAtlas_image1 = PBB_GE_SLC5A8_gnf1h02682_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLC5A8_gnf1h06296_at_tn.png
| GeneAtlas_image3 = PBB_GE_SLC5A8_gnf1h06297_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}}  
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 160728
    | Hs_Ensembl = ENSG00000139357
    | Hs_RefseqProtein = NP_666018
    | Hs_RefseqmRNA = NM_145913
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 100073697
    | Hs_GenLoc_end = 100128120
    | Hs_Uniprot = 
    | Mm_EntrezGene = 216225
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_001001565
    | Mm_RefseqProtein = XP_001001565
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
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'''Solute carrier family 5 (iodide transporter), member 8''', also known as '''SLC5A8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC5A8 solute carrier family 5 (iodide transporter), member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=160728| accessdate = }}</ref>
 
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{{PBB_Summary
| section_title =
| summary_text =
}}


==See also==
==See also==
Line 64: Line 7:
==References==
==References==
{{reflist}}
{{reflist}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Gupta N, Martin PM, Prasad PD, Ganapathy V |title=SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter |journal=Life Sci. |volume=78 |issue= 21 |pages= 2419–25 |year= 2006 |pmid= 16375929 |doi= 10.1016/j.lfs.2005.10.028 }}
| citations =
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Gupta N, Martin PM, Prasad PD, Ganapathy V |title=SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter. |journal=Life Sci. |volume=78 |issue= 21 |pages= 2419-25 |year= 2006 |pmid= 16375929 |doi= 10.1016/j.lfs.2005.10.028 }}
*{{cite journal  | vauthors=Miyauchi S, Gopal E, Fei YJ, Ganapathy V |title=Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids |journal=J. Biol. Chem. |volume=279 |issue= 14 |pages= 13293–6 |year= 2004 |pmid= 14966140 |doi= 10.1074/jbc.C400059200 }}
*{{cite journal | author=Rodriguez AM, Perron B, Lacroix L, ''et al.'' |title=Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 7 |pages= 3500-3 |year= 2002 |pmid= 12107270 |doi=  }}
*{{cite journal   |vauthors=Lacroix L, Pourcher T, Magnon C, etal |title=Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 3 |pages= 1423–8 |year= 2004 |pmid= 15001644 |doi=10.1210/jc.2003-030542 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Hong C, Maunakea A, Jun P, etal |title=Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8 |journal=Cancer Res. |volume=65 |issue= 9 |pages= 3617–23 |year= 2005 |pmid= 15867356 |doi= 10.1158/0008-5472.CAN-05-0048 }}
*{{cite journal | author=Li H, Myeroff L, Smiraglia D, ''et al.'' |title=SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 14 |pages= 8412-7 |year= 2003 |pmid= 12829793 |doi= 10.1073/pnas.1430846100 }}
*{{cite journal   |vauthors=Paroder V, Spencer SR, Paroder M, etal |title=Na+/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: Molecular characterization of SMCT |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 19 |pages= 7270–5 |year= 2006 |pmid= 16670197 |doi= 10.1073/pnas.0602365103 | pmc=1456061 }}
*{{cite journal  | author=Miyauchi S, Gopal E, Fei YJ, Ganapathy V |title=Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids. |journal=J. Biol. Chem. |volume=279 |issue= 14 |pages= 13293-6 |year= 2004 |pmid= 14966140 |doi= 10.1074/jbc.C400059200 }}
*{{cite journal   |vauthors=Hu S, Liu D, Tufano RP, etal |title=Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer |journal=Int. J. Cancer |volume=119 |issue= 10 |pages= 2322–9 |year= 2006 |pmid= 16858683 |doi= 10.1002/ijc.22110 }}
*{{cite journal | author=Lacroix L, Pourcher T, Magnon C, ''et al.'' |title=Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 3 |pages= 1423-8 |year= 2004 |pmid= 15001644 |doi=  }}
*{{cite journal   |vauthors=Gopal E, Miyauchi S, Martin PM, etal |title=Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract |journal=Pharm. Res. |volume=24 |issue= 3 |pages= 575–84 |year= 2007 |pmid= 17245649 |doi= 10.1007/s11095-006-9176-1 }}
*{{cite journal | author=Hong C, Maunakea A, Jun P, ''et al.'' |title=Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8. |journal=Cancer Res. |volume=65 |issue= 9 |pages= 3617-23 |year= 2005 |pmid= 15867356 |doi= 10.1158/0008-5472.CAN-05-0048 }}
*{{cite journal   |vauthors=Coady MJ, Wallendorff B, Bourgeois F, etal |title=Establishing a Definitive Stoichiometry for the Na+/Monocarboxylate Cotransporter SMCT1 |journal=Biophys. J. |volume=93 |issue= 7 |pages= 2325–31 |year= 2007 |pmid= 17526579 |doi= 10.1529/biophysj.107.108555 | pmc=1965447 }}
*{{cite journal | author=Paroder V, Spencer SR, Paroder M, ''et al.'' |title=Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 19 |pages= 7270-5 |year= 2006 |pmid= 16670197 |doi= 10.1073/pnas.0602365103 }}
*{{cite journal | author=Hu S, Liu D, Tufano RP, ''et al.'' |title=Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer. |journal=Int. J. Cancer |volume=119 |issue= 10 |pages= 2322-9 |year= 2006 |pmid= 16858683 |doi= 10.1002/ijc.22110 }}
*{{cite journal | author=Gopal E, Miyauchi S, Martin PM, ''et al.'' |title=Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract. |journal=Pharm. Res. |volume=24 |issue= 3 |pages= 575-84 |year= 2007 |pmid= 17245649 |doi= 10.1007/s11095-006-9176-1 }}
*{{cite journal | author=Coady MJ, Wallendorff B, Bourgeois F, ''et al.'' |title=Establishing a definitive stoichiometry for the Na+/monocarboxylate cotransporter SMCT1. |journal=Biophys. J. |volume=93 |issue= 7 |pages= 2325-31 |year= 2007 |pmid= 17526579 |doi= 10.1529/biophysj.107.108555 }}
}}
{{refend}}
{{refend}}


{{Membrane transport proteins}}
{{Solute carrier family|bg|bg0}}
 
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WH}}
 
{{WS}}
 
{{membrane-protein-stub}}

Latest revision as of 06:35, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sodium-coupled monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC5A8 gene.[1][2][3]

See also

References

  1. ↑ Rodriguez AM, Perron B, Lacroix L, Caillou B, Leblanc G, Schlumberger M, Bidart JM, Pourcher T (Jul 2002). "Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes". J Clin Endocrinol Metab. 87 (7): 3500–3. doi:10.1210/jc.87.7.3500. PMID 12107270.
  2. ↑ Li H, Myeroff L, Smiraglia D, Romero MF, Pretlow TP, Kasturi L, Lutterbaugh J, Rerko RM, Casey G, Issa JP, Willis J, Willson JK, Plass C, Markowitz SD (Jul 2003). "SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers". Proc Natl Acad Sci U S A. 100 (14): 8412–7. doi:10.1073/pnas.1430846100. PMC 166243. PMID 12829793.
  3. ↑ "Entrez Gene: SLC5A8 solute carrier family 5 (iodide transporter), member 8".

Further reading


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