SLC4A2: Difference between revisions

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Latest revision as of 09:58, 2 March 2018

Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene.^[1]^[2] AE2 is functionally similar to the Band 3 Cl⁻/HCO3⁻ exchange protein.

Mice have been used to explore the function of AE2. AE2 contributes to basolateral membrane HCO₃⁻ transport in the gastrointestinal tract.^[3] AE2 is required for spermiogenesis in mice.^[4] AE2 is required for normal osteoclast function.^[5]^[6] The activity of AE2 is sensitive to pH.^[7]

AE3 has been suggested as a target for prevention of diabetic vasculopathy.^[8]

References

↑ Tanner MJ (Mar 1993). "Molecular and cellular biology of the erythrocyte anion exchanger (AE1)". Semin Hematol. 30 (1): 34–57. PMID 8434259.
↑ "Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)".
↑ Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE (April 2010). "AE2 Cl⁻/HCO₃⁻ exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon". Am. J. Physiol. Gastrointest. Liver Physiol. 298 (4): G493–503. doi:10.1152/ajpgi.00178.2009. PMC 2853300. PMID 20110461.
↑ Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, Ottenhoff R, Bosma PJ, Bakker CT, Elferink RP (December 2003). "Anion exchanger 2 is essential for spermiogenesis in mice". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15847–52. doi:10.1073/pnas.2536127100. PMC 307656. PMID 14673081.
↑ Wu J, Glimcher LH, Aliprantis AO (November 2008). "HCO₃⁻/Cl⁻ anion exchanger SLC4A2 is required for proper osteoclast differentiation and function". Proc. Natl. Acad. Sci. U.S.A. 105 (44): 16934–9. doi:10.1073/pnas.0808763105. PMC 2579356. PMID 18971331.
↑ Josephsen K, Praetorius J, Frische S, Gawenis LR, Kwon TH, Agre P, Nielsen S, Fejerskov O (February 2009). "Targeted disruption of the Cl⁻/HCO₃⁻ exchanger Ae2 results in osteopetrosis in mice". Proc. Natl. Acad. Sci. U.S.A. 106 (5): 1638–41. doi:10.1073/pnas.0811682106. PMC 2635809. PMID 19164575.
↑ Stewart AK, Kurschat CE, Vaughan-Jones RD, Alper SL (March 2009). "Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH". J. Biol. Chem. 284 (10): 6126–39. doi:10.1074/jbc.M802051200. PMC 2649077. PMID 19103596.
↑ Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M (June 2010). "Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway". Apoptosis. 15 (6): 693–704. doi:10.1007/s10495-010-0477-9. PMID 20180022.

Gehrig H, Müller W, Appelhans H (1992). "Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney". Biochim. Biophys. Acta. 1130 (3): 326–8. doi:10.1016/0167-4781(92)90446-7. PMID 1562608.
Korsgren C, Cohen CM (1988). "Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3". J. Biol. Chem. 263 (21): 10212–8. PMID 2968981.
Demuth DR, Showe LC, Ballantine M, et al. (1986). "Cloning and structural characterization of a human non-erythroid band 3-like protein". EMBO J. 5 (6): 1205–14. PMC 1166929. PMID 3015590.
Palumbo AP, Isobe M, Huebner K, et al. (1986). "Chromosomal localization of a human band 3-like gene to region 7q35----7q36". Am. J. Hum. Genet. 39 (3): 307–16. PMC 1683956. PMID 3020980.
Rybicki AC, Musto S, Schwartz RS (1995). "Identification of a band-3 binding site near the N-terminus of erythrocyte membrane protein 4.2". Biochem. J. 309. ( Pt 2): 677–81. PMC 1135783. PMID 7626035.
Havenga MJ, Bosman GJ, Appelhans H, De Grip WJ (1995). "Expression of the anion exchanger (AE) gene family in human brain. Identification of a new AE protein: AE0". Brain Res. Mol. Brain Res. 25 (1–2): 97–104. doi:10.1016/0169-328X(94)90283-6. PMID 7984058.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Medina JF, Acín A, Prieto J (1997). "Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) gene". Genomics. 39 (1): 74–85. doi:10.1006/geno.1996.4467. PMID 9027488.
García C, Montuenga LM, Medina JF, Prieto J (1998). "In situ detection of AE2 anion-exchanger mRNA in the human liver". Cell Tissue Res. 291 (3): 481–8. doi:10.1007/s004410051017. PMID 9477304.
Jöns T, Drenckhahn D (1998). "Anion exchanger 2 (AE2) binds to erythrocyte ankyrin and is colocalized with ankyrin along the basolateral plasma membrane of human gastric parietal cells". Eur. J. Cell Biol. 75 (3): 232–6. doi:10.1016/s0171-9335(98)80117-9. PMID 9587054.
Mobasheri A, Golding S, Pagakis SN, et al. (1999). "Expression of cation exchanger NHE and anion exchanger AE isoforms in primary human bone-derived osteoblasts". Cell Biol. Int. 22 (7–8): 551–62. doi:10.1006/cbir.1998.0299. PMID 10452823.
Hyde K, Harrison D, Hollingsworth MA, Harris A (1999). "Chloride-bicarbonate exchangers in the human fetal pancreas". Biochem. Biophys. Res. Commun. 263 (2): 315–21. doi:10.1006/bbrc.1999.1367. PMID 10491290.
Holappa K, Mustonen M, Parvinen M, et al. (1999). "Primary structure of a sperm cell anion exchanger and its messenger ribonucleic acid expression during spermatogenesis". Biol. Reprod. 61 (4): 981–6. doi:10.1095/biolreprod61.4.981. PMID 10491633.
Karet FE, Finberg KE, Nayir A, et al. (2000). "Localization of a gene for autosomal recessive distal renal tubular acidosis with normal hearing (rdRTA2) to 7q33-34". Am. J. Hum. Genet. 65 (6): 1656–65. doi:10.1086/302679. PMC 1288376. PMID 10577919.
Medina JF, Lecanda J, Acín A, et al. (2000). "Tissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene". Biochem. Biophys. Res. Commun. 267 (1): 228–35. doi:10.1006/bbrc.1999.1951. PMID 10623603.
Vince JW, Reithmeier RA (2000). "Identification of the Carbonic Anhydrase II Binding Site in the Cl⁻/HCO₃⁻ Anion Exchanger AE1". Biochemistry. 39 (18): 5527–33. doi:10.1021/bi992564p. PMID 10820026.
Holappa K, Suokas M, Soininen P, Kellokumpu S (2001). "Identification of the full-length AE2 (AE2a) isoform as the Golgi-associated anion exchanger in fibroblasts". J. Histochem. Cytochem. 49 (2): 259–69. doi:10.1177/002215540104900213. PMID 11156694.
Soleimani M, Greeley T, Petrovic S, et al. (2001). "Pendrin: an apical Cl⁻/OH⁻/HCO³⁻ exchanger in the kidney cortex". Am. J. Physiol. Renal Physiol. 280 (2): F356–64. doi:10.1152/ajprenal.2001.280.2.f356. PMID 11208611.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[pmid8434259-1] Tanner MJ (Mar 1993). "Molecular and cellular biology of the erythrocyte anion exchanger (AE1)". Semin Hematol. 30 (1): 34–57. PMID 8434259.

[entrez-2] "Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)".

[pmid20110461-3] Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE (April 2010). "AE2 Cl⁻/HCO₃⁻ exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon". Am. J. Physiol. Gastrointest. Liver Physiol. 298 (4): G493–503. doi:10.1152/ajpgi.00178.2009. PMC 2853300. PMID 20110461.

[pmid14673081-4] Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, Ottenhoff R, Bosma PJ, Bakker CT, Elferink RP (December 2003). "Anion exchanger 2 is essential for spermiogenesis in mice". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15847–52. doi:10.1073/pnas.2536127100. PMC 307656. PMID 14673081.

[pmid18971331-5] Wu J, Glimcher LH, Aliprantis AO (November 2008). "HCO₃⁻/Cl⁻ anion exchanger SLC4A2 is required for proper osteoclast differentiation and function". Proc. Natl. Acad. Sci. U.S.A. 105 (44): 16934–9. doi:10.1073/pnas.0808763105. PMC 2579356. PMID 18971331.

[pmid19164575-6] Josephsen K, Praetorius J, Frische S, Gawenis LR, Kwon TH, Agre P, Nielsen S, Fejerskov O (February 2009). "Targeted disruption of the Cl⁻/HCO₃⁻ exchanger Ae2 results in osteopetrosis in mice". Proc. Natl. Acad. Sci. U.S.A. 106 (5): 1638–41. doi:10.1073/pnas.0811682106. PMC 2635809. PMID 19164575.

[pmid19103596-7] Stewart AK, Kurschat CE, Vaughan-Jones RD, Alper SL (March 2009). "Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH". J. Biol. Chem. 284 (10): 6126–39. doi:10.1074/jbc.M802051200. PMC 2649077. PMID 19103596.

[pmid20180022-8] Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M (June 2010). "Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway". Apoptosis. 15 (6): 693–704. doi:10.1007/s10495-010-0477-9. PMID 20180022.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Anion exchange protein 2''' (AE2) is a [[membrane transport protein]] that in humans is encoded by the ''SLC4A2'' [[gene]].<ref name="pmid8434259">{{cite journal | author = Tanner MJ | title = Molecular and cellular biology of the erythrocyte anion exchanger (AE1) | journal = Semin Hematol | volume = 30 | issue = 1 | pages = 34–57 |date=Mar 1993 | pmid = 8434259}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6522| accessdate = }}</ref> AE2 is functionally similar to the [[Band 3]] [[chloride|Cl<sup>−</sup>]]/[[bicarbonate|HCO3<sup>−</sup>]] [[Secondary active transport#Antiport|exchange]] protein.
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+[[Mice#Laboratory mice|Mice]] have been used to explore the function of AE2. AE2 contributes to [[Epithelial polarity#Basolateral membranes|basolateral membrane]] HCO<sub>3</sub><sup>−</sup> transport in the [[gastrointestinal tract]].<ref name="pmid20110461">{{cite journal | vauthors = Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE | title = AE2 Cl<sup>−</sup>/HCO<sub>3</sub><sup>−</sup> exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon | journal = Am. J. Physiol. Gastrointest. Liver Physiol. | volume = 298 | issue = 4 | pages = G493–503 |date=April 2010 | pmid = 20110461 | pmc = 2853300 | doi = 10.1152/ajpgi.00178.2009 }}</ref> AE2 is required for [[spermiogenesis]] in mice.<ref name="pmid14673081">{{cite journal | vauthors = Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, Ottenhoff R, Bosma PJ, Bakker CT, Elferink RP | title = Anion exchanger 2 is essential for spermiogenesis in mice | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 26 | pages = 15847–52 |date=December 2003 | pmid = 14673081 | pmc = 307656 | doi = 10.1073/pnas.2536127100 }}</ref> AE2 is required for normal [[osteoclast]] function.<ref name="pmid18971331">{{cite journal | vauthors = Wu J, Glimcher LH, Aliprantis AO | title = HCO<sub>3</sub><sup>−</sup>/Cl<sup>−</sup> anion exchanger SLC4A2 is required for proper osteoclast differentiation and function | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 105 | issue = 44 | pages = 16934–9 |date=November 2008 | pmid = 18971331 | pmc = 2579356 | doi = 10.1073/pnas.0808763105 | url = }}</ref><ref name="pmid19164575">{{cite journal | vauthors = Josephsen K, Praetorius J, Frische S, Gawenis LR, Kwon TH, Agre P, Nielsen S, Fejerskov O | title = Targeted disruption of the Cl<sup>−</sup>/HCO<sub>3</sub><sup>−</sup> exchanger Ae2 results in osteopetrosis in mice | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 106 | issue = 5 | pages = 1638–41 |date=February 2009 | pmid = 19164575 | pmc = 2635809 | doi = 10.1073/pnas.0811682106 }}</ref> The activity of AE2 is sensitive to [[pH]].<ref name="pmid19103596">{{cite journal | vauthors = Stewart AK, Kurschat CE, Vaughan-Jones RD, Alper SL | title = Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH | journal = J. Biol. Chem. | volume = 284 | issue = 10 | pages = 6126–39 |date=March 2009 | pmid = 19103596 | pmc = 2649077 | doi = 10.1074/jbc.M802051200 }}</ref>
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
- | HGNCid = 11028
- | Symbol = SLC4A2
- | AltSymbols =; AE2; BND3L; EPB3L1; HKB3; NBND3
- | OMIM = 109280
- | ECnumber =
- | Homologene = 31125
- | MGIid = 109351
- | GeneAtlas_image1 = PBB_GE_SLC4A2_202111_at_tn.png
- | Function = {{GNF_GO|id=GO:0005452 |text = inorganic anion exchanger activity}} {{GNF_GO|id=GO:0008509 |text = anion transmembrane transporter activity}} {{GNF_GO|id=GO:0015297 |text = antiporter activity}}
- | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006820 |text = anion transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 6522
-    | Hs_Ensembl = ENSG00000164889
-    | Hs_RefseqProtein = NP_003031
-    | Hs_RefseqmRNA = NM_003040
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 7
-    | Hs_GenLoc_start = 150386232
-    | Hs_GenLoc_end = 150404546
-    | Hs_Uniprot = P04920
-    | Mm_EntrezGene = 20535
-    | Mm_Ensembl = ENSMUSG00000028962
-    | Mm_RefseqmRNA = NM_009207
-    | Mm_RefseqProtein = NP_033233
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 5
-    | Mm_GenLoc_start = 23935384
-    | Mm_GenLoc_end = 23951010
-    | Mm_Uniprot = O54944
-  }}
-}}
-'''Solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)''', also known as '''SLC4A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6522| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+AE3 has been suggested as a target for prevention of [[Diabetes mellitus|diabetic vasculopathy]].<ref name="pmid20180022">{{cite journal | vauthors = Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M | title = Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway | journal = Apoptosis | volume = 15 | issue = 6 | pages = 693–704 |date=June 2010 | pmid = 20180022 | doi = 10.1007/s10495-010-0477-9 }}</ref>
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
 ==See also==
@@ Line 58: / Line 10: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+*{{cite journal  | vauthors=Gehrig H, Müller W, Appelhans H |title=Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney. |journal=Biochim. Biophys. Acta |volume=1130 |issue= 3 |pages= 326–8 |year= 1992 |pmid= 1562608 |doi=10.1016/0167-4781(92)90446-7}}
-| citations =
+*{{cite journal  | vauthors=Korsgren C, Cohen CM |title=Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3. |journal=J. Biol. Chem. |volume=263 |issue= 21 |pages= 10212–8 |year= 1988 |pmid= 2968981 }}
-*{{cite journal  | author=Tanner MJ |title=Molecular and cellular biology of the erythrocyte anion exchanger (AE1). |journal=Semin. Hematol. |volume=30 |issue= 1 |pages= 34-57 |year= 1993 |pmid= 8434259 |doi=  }}
+*{{cite journal   |vauthors=Demuth DR, Showe LC, Ballantine M, etal |title=Cloning and structural characterization of a human non-erythroid band 3-like protein. |journal=EMBO J. |volume=5 |issue= 6 |pages= 1205–14 |year= 1986 |pmid= 3015590 | pmc=1166929  }}
-*{{cite journal  | author=Gehrig H, Müller W, Appelhans H |title=Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney. |journal=Biochim. Biophys. Acta |volume=1130 |issue= 3 |pages= 326-8 |year= 1992 |pmid= 1562608 |doi=  }}
+*{{cite journal   |vauthors=Palumbo AP, Isobe M, Huebner K, etal |title=Chromosomal localization of a human band 3-like gene to region 7q35----7q36. |journal=Am. J. Hum. Genet. |volume=39 |issue= 3 |pages= 307–16 |year= 1986 |pmid= 3020980 | pmc=1683956  }}
-*{{cite journal  | author=Korsgren C, Cohen CM |title=Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3. |journal=J. Biol. Chem. |volume=263 |issue= 21 |pages= 10212-8 |year= 1988 |pmid= 2968981 |doi=  }}
+*{{cite journal  | vauthors=Rybicki AC, Musto S, Schwartz RS |title=Identification of a band-3 binding site near the N-terminus of erythrocyte membrane protein 4.2. | series=309 |journal=Biochem. J. |volume=( Pt 2) |issue=  |pages= 677–81 |year= 1995 |pmid= 7626035 | pmc=1135783  }}
-*{{cite journal  | author=Demuth DR, Showe LC, Ballantine M, ''et al.'' |title=Cloning and structural characterization of a human non-erythroid band 3-like protein. |journal=EMBO J. |volume=5 |issue= 6 |pages= 1205-14 |year= 1986 |pmid= 3015590 |doi=  }}
+*{{cite journal  | vauthors=Havenga MJ, Bosman GJ, Appelhans H, De Grip WJ |title=Expression of the anion exchanger (AE) gene family in human brain. Identification of a new AE protein: AE0. |journal=Brain Res. Mol. Brain Res. |volume=25 |issue= 1–2 |pages= 97–104 |year= 1995 |pmid= 7984058 |doi=10.1016/0169-328X(94)90283-6  }}
-*{{cite journal  | author=Palumbo AP, Isobe M, Huebner K, ''et al.'' |title=Chromosomal localization of a human band 3-like gene to region 7q35----7q36. |journal=Am. J. Hum. Genet. |volume=39 |issue= 3 |pages= 307-16 |year= 1986 |pmid= 3020980 |doi=  }}
+*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
-*{{cite journal  | author=Rybicki AC, Musto S, Schwartz RS |title=Identification of a band-3 binding site near the N-terminus of erythrocyte membrane protein 4.2. |journal=Biochem. J. |volume=309 ( Pt 2) |issue=  |pages= 677-81 |year= 1995 |pmid= 7626035 |doi=  }}
+*{{cite journal  | vauthors=Medina JF, Acín A, Prieto J |title=Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) gene. |journal=Genomics |volume=39 |issue= 1 |pages= 74–85 |year= 1997 |pmid= 9027488 |doi=10.1006/geno.1996.4467  }}
-*{{cite journal  | author=Havenga MJ, Bosman GJ, Appelhans H, De Grip WJ |title=Expression of the anion exchanger (AE) gene family in human brain. Identification of a new AE protein: AE0. |journal=Brain Res. Mol. Brain Res. |volume=25 |issue= 1-2 |pages= 97-104 |year= 1995 |pmid= 7984058 |doi=  }}
+*{{cite journal  | vauthors=García C, Montuenga LM, Medina JF, Prieto J |title=In situ detection of AE2 anion-exchanger mRNA in the human liver. |journal=Cell Tissue Res. |volume=291 |issue= 3 |pages= 481–8 |year= 1998 |pmid= 9477304 |doi=10.1007/s004410051017  }}
-*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
+*{{cite journal  | vauthors=Jöns T, Drenckhahn D |title=Anion exchanger 2 (AE2) binds to erythrocyte ankyrin and is colocalized with ankyrin along the basolateral plasma membrane of human gastric parietal cells. |journal=Eur. J. Cell Biol. |volume=75 |issue= 3 |pages= 232–6 |year= 1998 |pmid= 9587054 |doi=10.1016/s0171-9335(98)80117-9}}
-*{{cite journal  | author=Medina JF, Acín A, Prieto J |title=Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) gene. |journal=Genomics |volume=39 |issue= 1 |pages= 74-85 |year= 1997 |pmid= 9027488 |doi=  }}
+*{{cite journal   |vauthors=Mobasheri A, Golding S, Pagakis SN, etal |title=Expression of cation exchanger NHE and anion exchanger AE isoforms in primary human bone-derived osteoblasts. |journal=Cell Biol. Int. |volume=22 |issue= 7–8 |pages= 551–62 |year= 1999 |pmid= 10452823 |doi= 10.1006/cbir.1998.0299 }}
-*{{cite journal  | author=García C, Montuenga LM, Medina JF, Prieto J |title=In situ detection of AE2 anion-exchanger mRNA in the human liver. |journal=Cell Tissue Res. |volume=291 |issue= 3 |pages= 481-8 |year= 1998 |pmid= 9477304 |doi=  }}
+*{{cite journal  | vauthors=Hyde K, Harrison D, Hollingsworth MA, Harris A |title=Chloride-bicarbonate exchangers in the human fetal pancreas. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 2 |pages= 315–21 |year= 1999 |pmid= 10491290 |doi= 10.1006/bbrc.1999.1367 }}
-*{{cite journal  | author=Jöns T, Drenckhahn D |title=Anion exchanger 2 (AE2) binds to erythrocyte ankyrin and is colocalized with ankyrin along the basolateral plasma membrane of human gastric parietal cells. |journal=Eur. J. Cell Biol. |volume=75 |issue= 3 |pages= 232-6 |year= 1998 |pmid= 9587054 |doi=  }}
+*{{cite journal   |vauthors=Holappa K, Mustonen M, Parvinen M, etal |title=Primary structure of a sperm cell anion exchanger and its messenger ribonucleic acid expression during spermatogenesis. |journal=Biol. Reprod. |volume=61 |issue= 4 |pages= 981–6 |year= 1999 |pmid= 10491633 |doi=10.1095/biolreprod61.4.981  }}
-*{{cite journal  | author=Mobasheri A, Golding S, Pagakis SN, ''et al.'' |title=Expression of cation exchanger NHE and anion exchanger AE isoforms in primary human bone-derived osteoblasts. |journal=Cell Biol. Int. |volume=22 |issue= 7-8 |pages= 551-62 |year= 1999 |pmid= 10452823 |doi= 10.1006/cbir.1998.0299 }}
+*{{cite journal   |vauthors=Karet FE, Finberg KE, Nayir A, etal |title=Localization of a gene for autosomal recessive distal renal tubular acidosis with normal hearing (rdRTA2) to 7q33-34. |journal=Am. J. Hum. Genet. |volume=65 |issue= 6 |pages= 1656–65 |year= 2000 |pmid= 10577919 |doi=10.1086/302679  | pmc=1288376  }}
-*{{cite journal  | author=Hyde K, Harrison D, Hollingsworth MA, Harris A |title=Chloride-bicarbonate exchangers in the human fetal pancreas. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 2 |pages= 315-21 |year= 1999 |pmid= 10491290 |doi= 10.1006/bbrc.1999.1367 }}
+*{{cite journal   |vauthors=Medina JF, Lecanda J, Acín A, etal |title=Tissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene. |journal=Biochem. Biophys. Res. Commun. |volume=267 |issue= 1 |pages= 228–35 |year= 2000 |pmid= 10623603 |doi= 10.1006/bbrc.1999.1951 }}
-*{{cite journal  | author=Holappa K, Mustonen M, Parvinen M, ''et al.'' |title=Primary structure of a sperm cell anion exchanger and its messenger ribonucleic acid expression during spermatogenesis. |journal=Biol. Reprod. |volume=61 |issue= 4 |pages= 981-6 |year= 1999 |pmid= 10491633 |doi=  }}
+*{{cite journal  | vauthors=Vince JW, Reithmeier RA |title=Identification of the Carbonic Anhydrase II Binding Site in the Cl<sup>−</sup>/HCO<sub>3</sub><sup>−</sup> Anion Exchanger AE1. |journal=Biochemistry |volume=39 |issue= 18 |pages= 5527–33 |year= 2000 |pmid= 10820026 |doi=10.1021/bi992564p  }}
-*{{cite journal  | author=Karet FE, Finberg KE, Nayir A, ''et al.'' |title=Localization of a gene for autosomal recessive distal renal tubular acidosis with normal hearing (rdRTA2) to 7q33-34. |journal=Am. J. Hum. Genet. |volume=65 |issue= 6 |pages= 1656-65 |year= 2000 |pmid= 10577919 |doi=  }}
+*{{cite journal  | vauthors=Holappa K, Suokas M, Soininen P, Kellokumpu S |title=Identification of the full-length AE2 (AE2a) isoform as the Golgi-associated anion exchanger in fibroblasts. |journal=J. Histochem. Cytochem. |volume=49 |issue= 2 |pages= 259–69 |year= 2001 |pmid= 11156694 |doi=10.1177/002215540104900213}}
-*{{cite journal  | author=Medina JF, Lecanda J, Acín A, ''et al.'' |title=Tissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene. |journal=Biochem. Biophys. Res. Commun. |volume=267 |issue= 1 |pages= 228-35 |year= 2000 |pmid= 10623603 |doi= 10.1006/bbrc.1999.1951 }}
+*{{cite journal   |vauthors=Soleimani M, Greeley T, Petrovic S, etal |title=Pendrin: an apical Cl<sup>−</sup>/OH<sup>−</sup>/HCO<sup>3</sup><sup>−</sup> exchanger in the kidney cortex. |journal=Am. J. Physiol. Renal Physiol. |volume=280 |issue= 2 |pages= F356–64 |year= 2001 |pmid= 11208611 |doi=10.1152/ajprenal.2001.280.2.f356}}
-*{{cite journal  | author=Vince JW, Reithmeier RA |title=Identification of the carbonic anhydrase II binding site in the Cl(-)/HCO(3)(-) anion exchanger AE1. |journal=Biochemistry |volume=39 |issue= 18 |pages= 5527-33 |year= 2000 |pmid= 10820026 |doi=  }}
-*{{cite journal  | author=Holappa K, Suokas M, Soininen P, Kellokumpu S |title=Identification of the full-length AE2 (AE2a) isoform as the Golgi-associated anion exchanger in fibroblasts. |journal=J. Histochem. Cytochem. |volume=49 |issue= 2 |pages= 259-69 |year= 2001 |pmid= 11156694 |doi=  }}
-*{{cite journal  | author=Soleimani M, Greeley T, Petrovic S, ''et al.'' |title=Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex. |journal=Am. J. Physiol. Renal Physiol. |volume=280 |issue= 2 |pages= F356-64 |year= 2001 |pmid= 11208611 |doi=  }}
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-{{membrane-protein-stub}}
 {{NLM content}}
-{{Membrane transport proteins}}
+{{Solute carrier family|bg|bg0}}
 [[Category:Solute carrier family]]
-{{WikiDoc Sources}}
+{{membrane-protein-stub}}

SLC4A2: Difference between revisions

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