SLC38A2: Difference between revisions

VALUE_ERROR (nil)
Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

VisualWikitext

Latest revision as of 06:32, 11 September 2017

Sodium-coupled neutral amino acid transporter 2 is a protein that in humans is encoded by the SLC38A2 gene.^[1]^[2]^[3]

References

↑ Sugawara M, Nakanishi T, Fei YJ, Huang W, Ganapathy ME, Leibach FH, Ganapathy V (Jul 2000). "Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A". J Biol Chem. 275 (22): 16473–7. doi:10.1074/jbc.C000205200. PMID 10747860.
↑ Zhang Z, Grewer C (Mar 2007). "The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates". Biophys J. 92 (7): 2621–32. doi:10.1529/biophysj.106.100776. PMC 1864845. PMID 17237199.
↑ "Entrez Gene: SLC38A2 solute carrier family 38, member 2".

Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Hatanaka T, Huang W, Wang H, et al. (2000). "Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A.". Biochim. Biophys. Acta. 1467 (1): 1–6. doi:10.1016/S0005-2736(00)00252-2. PMID 10930503.
Freeman TL, Thiele GM, Tuma DJ, et al. (2002). "ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane". Arch. Biochem. Biophys. 400 (2): 215–22. doi:10.1016/S0003-9861(02)00006-1. PMID 12054432.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Palii SS, Chen H, Kilberg MS (2004). "Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element". J. Biol. Chem. 279 (5): 3463–71. doi:10.1074/jbc.M310483200. PMID 14623874.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Franchi-Gazzola R, Gaccioli F, Bevilacqua E, et al. (2005). "The synthesis of SNAT2 transporters is required for the hypertonic stimulation of system A transport activity". Biochim. Biophys. Acta. 1667 (2): 157–66. doi:10.1016/j.bbamem.2004.09.012. PMID 15581851.
Bevilacqua E, Bussolati O, Dall'Asta V, et al. (2005). "SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress". FEBS Lett. 579 (16): 3376–80. doi:10.1016/j.febslet.2005.05.002. PMID 15922329.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Novak D, Quiggle F, Haafiz A (2006). "Impact of forskolin and amino acid depletion upon System A activity and SNAT expression in BeWo cells". Biochimie. 88 (1): 39–44. doi:10.1016/j.biochi.2005.07.002. PMID 16125834.
Palii SS, Thiaville MM, Pan YX, et al. (2006). "Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene". Biochem. J. 395 (3): 517–27. doi:10.1042/BJ20051867. PMC 1462688. PMID 16445384.
Melone M, Varoqui H, Erickson JD, Conti F (2006). "Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex". Neuroscience. 140 (1): 281–92. doi:10.1016/j.neuroscience.2006.02.042. PMID 16616430.
Gaccioli F, Huang CC, Wang C, et al. (2006). "Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation". J. Biol. Chem. 281 (26): 17929–40. doi:10.1074/jbc.M600341200. PMID 16621798.
Jones HN, Ashworth CJ, Page KR, McArdle HJ (2006). "Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo)". Am. J. Physiol. Endocrinol. Metab. 291 (3): E596–603. doi:10.1152/ajpendo.00359.2005. PMID 16621896.

Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[pmid10747860-1] Sugawara M, Nakanishi T, Fei YJ, Huang W, Ganapathy ME, Leibach FH, Ganapathy V (Jul 2000). "Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A". J Biol Chem. 275 (22): 16473–7. doi:10.1074/jbc.C000205200. PMID 10747860.

[pmid17237199-2] Zhang Z, Grewer C (Mar 2007). "The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates". Biophys J. 92 (7): 2621–32. doi:10.1529/biophysj.106.100776. PMC 1864845. PMID 17237199.

[entrez-3] "Entrez Gene: SLC38A2 solute carrier family 38, member 2".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Sodium-coupled neutral amino acid transporter 2''' is a [[protein]] that in humans is encoded by the ''SLC38A2'' [[gene]].<ref name="pmid10747860">{{cite journal | vauthors = Sugawara M, Nakanishi T, Fei YJ, Huang W, Ganapathy ME, Leibach FH, Ganapathy V | title = Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A | journal = J Biol Chem | volume = 275 | issue = 22 | pages = 16473–7 |date=Jul 2000 | pmid = 10747860 | pmc =  | doi = 10.1074/jbc.C000205200 }}</ref><ref name="pmid17237199">{{cite journal | vauthors = Zhang Z, Grewer C | title = The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates | journal = Biophys J | volume = 92 | issue = 7 | pages = 2621–32 |date=Mar 2007 | pmid = 17237199 | pmc = 1864845 | doi = 10.1529/biophysj.106.100776 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC38A2 solute carrier family 38, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54407| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 38, member 2
- | HGNCid = 13448
- | Symbol = SLC38A2
- | AltSymbols =; PRO1068; ATA2; KIAA1382; SAT2; SNAT2
- | OMIM = 605180
- | ECnumber =
- | Homologene = 23132
- | MGIid = 1915010
-  | GeneAtlas_image1 = PBB_GE_SLC38A2_220924_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_SLC38A2_218041_x_at_tn.png
- | Function =
- | Component =
- | Process =
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 54407
-    | Hs_Ensembl = ENSG00000134294
-    | Hs_RefseqProtein = NP_061849
-    | Hs_RefseqmRNA = NM_018976
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 12
-    | Hs_GenLoc_start = 45038239
-    | Hs_GenLoc_end = 45052824
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 67760
-    | Mm_Ensembl = ENSMUSG00000022462
-    | Mm_RefseqmRNA = NM_175121
-    | Mm_RefseqProtein = NP_780330
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 15
-    | Mm_GenLoc_start = 96515426
-    | Mm_GenLoc_end = 96527732
-    | Mm_Uniprot =
-  }}
-}}
-'''Solute carrier family 38, member 2''', also known as '''SLC38A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC38A2 solute carrier family 38, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54407| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
@@ Line 59: / Line 11: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 65: / Line 17: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Nagase T, Kikuno R, Ishikawa KI, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65-73 |year= 2000 |pmid= 10718198 |doi=  }}
+*{{cite journal   |vauthors=Nagase T, Kikuno R, Ishikawa KI, etal |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65–73 |year= 2000 |pmid= 10718198 |doi=10.1093/dnares/7.1.65  }}
-*{{cite journal  | author=Sugawara M, Nakanishi T, Fei YJ, ''et al.'' |title=Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 16473-7 |year= 2000 |pmid= 10747860 |doi= 10.1074/jbc.C000205200 }}
+*{{cite journal   |vauthors=Hatanaka T, Huang W, Wang H, etal |title=Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A. |journal=Biochim. Biophys. Acta |volume=1467 |issue= 1 |pages= 1–6 |year= 2000 |pmid= 10930503 |doi=10.1016/S0005-2736(00)00252-2  }}
-*{{cite journal  | author=Hatanaka T, Huang W, Wang H, ''et al.'' |title=Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A. |journal=Biochim. Biophys. Acta |volume=1467 |issue= 1 |pages= 1-6 |year= 2000 |pmid= 10930503 |doi=  }}
+*{{cite journal   |vauthors=Freeman TL, Thiele GM, Tuma DJ, etal |title=ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane. |journal=Arch. Biochem. Biophys. |volume=400 |issue= 2 |pages= 215–22 |year= 2002 |pmid= 12054432 |doi= 10.1016/S0003-9861(02)00006-1 }}
-*{{cite journal  | author=Freeman TL, Thiele GM, Tuma DJ, ''et al.'' |title=ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane. |journal=Arch. Biochem. Biophys. |volume=400 |issue= 2 |pages= 215-22 |year= 2002 |pmid= 12054432 |doi= 10.1016/S0003-9861(02)00006-1 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Palii SS, Chen H, Kilberg MS |title=Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element. |journal=J. Biol. Chem. |volume=279 |issue= 5 |pages= 3463–71 |year= 2004 |pmid= 14623874 |doi= 10.1074/jbc.M310483200 }}
-*{{cite journal  | author=Palii SS, Chen H, Kilberg MS |title=Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element. |journal=J. Biol. Chem. |volume=279 |issue= 5 |pages= 3463-71 |year= 2004 |pmid= 14623874 |doi= 10.1074/jbc.M310483200 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Franchi-Gazzola R, Gaccioli F, Bevilacqua E, etal |title=The synthesis of SNAT2 transporters is required for the hypertonic stimulation of system A transport activity. |journal=Biochim. Biophys. Acta |volume=1667 |issue= 2 |pages= 157–66 |year= 2005 |pmid= 15581851 |doi= 10.1016/j.bbamem.2004.09.012 }}
-*{{cite journal  | author=Franchi-Gazzola R, Gaccioli F, Bevilacqua E, ''et al.'' |title=The synthesis of SNAT2 transporters is required for the hypertonic stimulation of system A transport activity. |journal=Biochim. Biophys. Acta |volume=1667 |issue= 2 |pages= 157-66 |year= 2005 |pmid= 15581851 |doi= 10.1016/j.bbamem.2004.09.012 }}
+*{{cite journal   |vauthors=Bevilacqua E, Bussolati O, Dall'Asta V, etal |title=SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress. |journal=FEBS Lett. |volume=579 |issue= 16 |pages= 3376–80 |year= 2005 |pmid= 15922329 |doi= 10.1016/j.febslet.2005.05.002 }}
-*{{cite journal  | author=Bevilacqua E, Bussolati O, Dall'Asta V, ''et al.'' |title=SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress. |journal=FEBS Lett. |volume=579 |issue= 16 |pages= 3376-80 |year= 2005 |pmid= 15922329 |doi= 10.1016/j.febslet.2005.05.002 }}
+*{{cite journal   |vauthors=Zhang Y, Wolf-Yadlin A, Ross PL, etal |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell. Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 }}
-*{{cite journal  | author=Zhang Y, Wolf-Yadlin A, Ross PL, ''et al.'' |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell Proteomics |volume=4 |issue= 9 |pages= 1240-50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 }}
+*{{cite journal  | vauthors=Novak D, Quiggle F, Haafiz A |title=Impact of forskolin and amino acid depletion upon System A activity and SNAT expression in BeWo cells. |journal=Biochimie |volume=88 |issue= 1 |pages= 39–44 |year= 2006 |pmid= 16125834 |doi= 10.1016/j.biochi.2005.07.002 }}
-*{{cite journal  | author=Novak D, Quiggle F, Haafiz A |title=Impact of forskolin and amino acid depletion upon System A activity and SNAT expression in BeWo cells. |journal=Biochimie |volume=88 |issue= 1 |pages= 39-44 |year= 2006 |pmid= 16125834 |doi= 10.1016/j.biochi.2005.07.002 }}
+*{{cite journal   |vauthors=Palii SS, Thiaville MM, Pan YX, etal |title=Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene. |journal=Biochem. J. |volume=395 |issue= 3 |pages= 517–27 |year= 2006 |pmid= 16445384 |doi= 10.1042/BJ20051867  | pmc=1462688 }}
-*{{cite journal  | author=Palii SS, Thiaville MM, Pan YX, ''et al.'' |title=Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene. |journal=Biochem. J. |volume=395 |issue= 3 |pages= 517-27 |year= 2006 |pmid= 16445384 |doi= 10.1042/BJ20051867 }}
+*{{cite journal  | vauthors=Melone M, Varoqui H, Erickson JD, Conti F |title=Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex. |journal=Neuroscience |volume=140 |issue= 1 |pages= 281–92 |year= 2006 |pmid= 16616430 |doi= 10.1016/j.neuroscience.2006.02.042 }}
-*{{cite journal  | author=Melone M, Varoqui H, Erickson JD, Conti F |title=Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex. |journal=Neuroscience |volume=140 |issue= 1 |pages= 281-92 |year= 2006 |pmid= 16616430 |doi= 10.1016/j.neuroscience.2006.02.042 }}
+*{{cite journal   |vauthors=Gaccioli F, Huang CC, Wang C, etal |title=Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation. |journal=J. Biol. Chem. |volume=281 |issue= 26 |pages= 17929–40 |year= 2006 |pmid= 16621798 |doi= 10.1074/jbc.M600341200 }}
-*{{cite journal  | author=Gaccioli F, Huang CC, Wang C, ''et al.'' |title=Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation. |journal=J. Biol. Chem. |volume=281 |issue= 26 |pages= 17929-40 |year= 2006 |pmid= 16621798 |doi= 10.1074/jbc.M600341200 }}
+*{{cite journal  | vauthors=Jones HN, Ashworth CJ, Page KR, McArdle HJ |title=Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo). |journal=Am. J. Physiol. Endocrinol. Metab. |volume=291 |issue= 3 |pages= E596–603 |year= 2006 |pmid= 16621896 |doi= 10.1152/ajpendo.00359.2005 }}
-*{{cite journal  | author=Jones HN, Ashworth CJ, Page KR, McArdle HJ |title=Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo). |journal=Am. J. Physiol. Endocrinol. Metab. |volume=291 |issue= 3 |pages= E596-603 |year= 2006 |pmid= 16621896 |doi= 10.1152/ajpendo.00359.2005 }}
-*{{cite journal  | author=Zhang Z, Grewer C |title=The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates. |journal=Biophys. J. |volume=92 |issue= 7 |pages= 2621-32 |year= 2007 |pmid= 17237199 |doi= 10.1529/biophysj.106.100776 }}
 }}
 {{refend}}
-{{membrane-protein-stub}}
 {{Membrane transport proteins}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
 [[Category:Solute carrier family]]
-{{WikiDoc Sources}}
+{{membrane-protein-stub}}

SLC38A2: Difference between revisions

Latest revision as of 06:32, 11 September 2017

See also

References

Further reading

Navigation menu