SH2B2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''SH2B adapter protein 2''' is a [[protein]] that in humans is encoded by the ''SH2B2'' [[gene]].<ref name="pmid9233773">{{cite journal | vauthors = Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A | title = Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation | journal = Oncogene | volume = 15 | issue = 1 | pages = 7–15 | date = Aug 1997 | pmid = 9233773 | pmc =  | doi = 10.1038/sj.onc.1201163 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SH2B2 SH2B adaptor protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10603| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_SH2B2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1q2h.
| PDB = {{PDB2|1q2h}}, {{PDB2|1rpy}}, {{PDB2|1rqq}}, {{PDB2|1v5m}}
| Name = SH2B adaptor protein 2
| HGNCid = 17381
| Symbol = SH2B2
| AltSymbols =; APS
| OMIM = 605300
| ECnumber = 
| Homologene = 10309
| MGIid = 1345171
| Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0008269 |text = JAK pathway signal transduction adaptor activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10603
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_066189
    | Hs_RefseqmRNA = NM_020979
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 23921
    | Mm_Ensembl = ENSMUSG00000005057
    | Mm_RefseqmRNA = NM_018825
    | Mm_RefseqProtein = NP_061295
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 136502776
    | Mm_GenLoc_end = 136529530
    | Mm_Uniprot = Q6PG00
  }}
}}
'''SH2B adaptor protein 2''', also known as '''SH2B2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SH2B2 SH2B adaptor protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10603| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.<ref name="entrez">{{cite web | title = Entrez Gene: SH2B2 SH2B adaptor protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10603| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SH2B2 has been shown to [[Protein-protein interaction|interact]] with [[TrkA]]<ref name=pmid9856458>{{cite journal | vauthors = Qian X, Riccio A, Zhang Y, Ginty DD | title = Identification and characterization of novel substrates of Trk receptors in developing neurons | journal = Neuron | volume = 21 | issue = 5 | pages = 1017–29 | date = Nov 1998 | pmid = 9856458 | doi = 10.1016/S0896-6273(00)80620-0 }}</ref> and [[Cbl gene]].<ref name=pmid10374881>{{cite journal | vauthors = Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A | title = APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl | journal = Leukemia | volume = 13 | issue = 5 | pages = 760–7 | date = May 1999 | pmid = 10374881 | doi = 10.1038/sj/leu/2401397 }}</ref><ref name=pmid18273061>{{cite journal | vauthors = Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J | title = Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates | journal = EMBO J. | volume = 27 | issue = 5 | pages = 804–16 | date = Mar 2008 | pmid = 18273061 | pmc = 2265755 | doi = 10.1038/emboj.2008.18 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A | title = Large-Scale Sequencing of Two Regions in Human Chromosome 7q22: Analysis of 650 kb of Genomic Sequence around the EPO and CUTL1 Loci Reveals 17 Genes | journal = Genome Res. | volume = 8 | issue = 10 | pages = 1060–73 | year = 1998 | pmid = 9799793 | pmc = 310788 | doi = 10.1101/gr.8.10.1060 }}
| citations =
* {{cite journal | vauthors = Qian X, Riccio A, Zhang Y, Ginty DD | title = Identification and characterization of novel substrates of Trk receptors in developing neurons | journal = Neuron | volume = 21 | issue = 5 | pages = 1017–29 | year = 1999 | pmid = 9856458 | doi = 10.1016/S0896-6273(00)80620-0 }}
*{{cite journal | author=Yokouchi M, Suzuki R, Masuhara M, ''et al.'' |title=Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation. |journal=Oncogene |volume=15 |issue= 1 |pages= 7-15 |year= 1997 |pmid= 9233773 |doi= 10.1038/sj.onc.1201163 }}
* {{cite journal | vauthors = Yokouchi M, Wakioka T, Sakamoto H, Yasukawa H, Ohtsuka S, Sasaki A, Ohtsubo M, Valius M, Inoue A, Komiya S, Yoshimura A | title = APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis | journal = Oncogene | volume = 18 | issue = 3 | pages = 759–67 | year = 1999 | pmid = 9989826 | doi = 10.1038/sj.onc.1202326 }}
*{{cite journal  | author=Glöckner G, Scherer S, Schattevoy R, ''et al.'' |title=Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. |journal=Genome Res. |volume=8 |issue= 10 |pages= 1060-73 |year= 1998 |pmid= 9799793 |doi= }}
* {{cite journal | vauthors = Moodie SA, Alleman-Sposeto J, Gustafson TA | title = Identification of the APS protein as a novel insulin receptor substrate | journal = J. Biol. Chem. | volume = 274 | issue = 16 | pages = 11186–93 | year = 1999 | pmid = 10196204 | doi = 10.1074/jbc.274.16.11186 }}
*{{cite journal | author=Qian X, Riccio A, Zhang Y, Ginty DD |title=Identification and characterization of novel substrates of Trk receptors in developing neurons. |journal=Neuron |volume=21 |issue= 5 |pages= 1017-29 |year= 1999 |pmid= 9856458 |doi= }}
* {{cite journal | vauthors = Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A | title = APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl | journal = Leukemia | volume = 13 | issue = 5 | pages = 760–7 | year = 1999 | pmid = 10374881 | doi = 10.1038/sj/leu/2401397 }}
*{{cite journal | author=Yokouchi M, Wakioka T, Sakamoto H, ''et al.'' |title=APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis. |journal=Oncogene |volume=18 |issue= 3 |pages= 759-67 |year= 1999 |pmid= 9989826 |doi= 10.1038/sj.onc.1202326 }}
* {{cite journal | vauthors = Iseki M, Takaki S, Takatsu K | title = Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins | journal = Biochem. Biophys. Res. Commun. | volume = 272 | issue = 1 | pages = 45–54 | year = 2000 | pmid = 10872802 | doi = 10.1006/bbrc.2000.2736 }}
*{{cite journal | author=Moodie SA, Alleman-Sposeto J, Gustafson TA |title=Identification of the APS protein as a novel insulin receptor substrate. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11186-93 |year= 1999 |pmid= 10196204 |doi= }}
* {{cite journal | vauthors = O'Brien KB, O'Shea JJ, Carter-Su C | title = SH2-B family members differentially regulate JAK family tyrosine kinases | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 8673–81 | year = 2002 | pmid = 11751854 | doi = 10.1074/jbc.M109165200 }}
*{{cite journal | author=Wakioka T, Sasaki A, Mitsui K, ''et al.'' |title=APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl. |journal=Leukemia |volume=13 |issue= 5 |pages= 760-7 |year= 1999 |pmid= 10374881 |doi= }}
* {{cite journal | vauthors = Liu J, Kimura A, Baumann CA, Saltiel AR | title = APS Facilitates c-Cbl Tyrosine Phosphorylation and GLUT4 Translocation in Response to Insulin in 3T3-L1 Adipocytes | journal = Mol. Cell. Biol. | volume = 22 | issue = 11 | pages = 3599–609 | year = 2002 | pmid = 11997497 | pmc = 133825 | doi = 10.1128/MCB.22.11.3599-3609.2002 }}
*{{cite journal | author=Iseki M, Takaki S, Takatsu K |title=Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 1 |pages= 45-54 |year= 2000 |pmid= 10872802 |doi= 10.1006/bbrc.2000.2736 }}
* {{cite journal | vauthors = Yabana N, Shibuya M | title = Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity | journal = Oncogene | volume = 21 | issue = 50 | pages = 7720–9 | year = 2002 | pmid = 12400014 | doi = 10.1038/sj.onc.1205927 }}
*{{cite journal | author=O'Brien KB, O'Shea JJ, Carter-Su C |title=SH2-B family members differentially regulate JAK family tyrosine kinases. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8673-81 |year= 2002 |pmid= 11751854 |doi= 10.1074/jbc.M109165200 }}
* {{cite journal | vauthors = Ahn MY, Katsanakis KD, Bheda F, Pillay TS | title = Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling | journal = J. Biol. Chem. | volume = 279 | issue = 20 | pages = 21526–32 | year = 2004 | pmid = 15031295 | doi = 10.1074/jbc.M307740200 }}
*{{cite journal | author=Liu J, Kimura A, Baumann CA, Saltiel AR |title=APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. |journal=Mol. Cell. Biol. |volume=22 |issue= 11 |pages= 3599-609 |year= 2002 |pmid= 11997497 |doi= }}
* {{cite journal | vauthors = Wilcox A, Katsanakis KD, Bheda F, Pillay TS | title = Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex | journal = J. Biol. Chem. | volume = 279 | issue = 37 | pages = 38881–8 | year = 2004 | pmid = 15231829 | doi = 10.1074/jbc.M406101200 }}
*{{cite journal | author=Yabana N, Shibuya M |title=Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. |journal=Oncogene |volume=21 |issue= 50 |pages= 7720-9 |year= 2002 |pmid= 12400014 |doi= 10.1038/sj.onc.1205927 }}
* {{cite journal | vauthors = Hu J, Hubbard SR | title = Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins | journal = J. Biol. Chem. | volume = 280 | issue = 19 | pages = 18943–9 | year = 2005 | pmid = 15737992 | doi = 10.1074/jbc.M414157200 }}
*{{cite journal | author=Ahn MY, Katsanakis KD, Bheda F, Pillay TS |title=Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling. |journal=J. Biol. Chem. |volume=279 |issue= 20 |pages= 21526-32 |year= 2004 |pmid= 15031295 |doi= 10.1074/jbc.M307740200 }}
* {{cite journal | vauthors = Iseki M, Kubo-Akashi C, Kwon SM, Yamaguchi A, Takatsu K, Takaki S | title = APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation | journal = Biochem. Biophys. Res. Commun. | volume = 330 | issue = 3 | pages = 1005–13 | year = 2005 | pmid = 15809095 | doi = 10.1016/j.bbrc.2005.03.073 }}
*{{cite journal | author=Wilcox A, Katsanakis KD, Bheda F, Pillay TS |title=Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex. |journal=J. Biol. Chem. |volume=279 |issue= 37 |pages= 38881-8 |year= 2004 |pmid= 15231829 |doi= 10.1074/jbc.M406101200 }}
* {{cite journal | vauthors = Katsanakis KD, Pillay TS | title = Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588 | journal = J. Biol. Chem. | volume = 280 | issue = 45 | pages = 37827–32 | year = 2006 | pmid = 16141217 | doi = 10.1074/jbc.M505959200 }}
*{{cite journal | author=Hu J, Hubbard SR |title=Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins. |journal=J. Biol. Chem. |volume=280 |issue= 19 |pages= 18943-9 |year= 2005 |pmid= 15737992 |doi= 10.1074/jbc.M414157200 }}
* {{cite journal | vauthors = Li M, Li Z, Morris DL, Rui L | title = Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling | journal = Endocrinology | volume = 148 | issue = 4 | pages = 1615–21 | year = 2007 | pmid = 17204555 | doi = 10.1210/en.2006-1010 | pmc = 4710543 }}
*{{cite journal | author=Iseki M, Kubo-Akashi C, Kwon SM, ''et al.'' |title=APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation. |journal=Biochem. Biophys. Res. Commun. |volume=330 |issue= 3 |pages= 1005-13 |year= 2005 |pmid= 15809095 |doi= 10.1016/j.bbrc.2005.03.073 }}
*{{cite journal | author=Katsanakis KD, Pillay TS |title=Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588. |journal=J. Biol. Chem. |volume=280 |issue= 45 |pages= 37827-32 |year= 2006 |pmid= 16141217 |doi= 10.1074/jbc.M505959200 }}
*{{cite journal | author=Li M, Li Z, Morris DL, Rui L |title=Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling. |journal=Endocrinology |volume=148 |issue= 4 |pages= 1615-21 |year= 2007 |pmid= 17204555 |doi= 10.1210/en.2006-1010 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=10603}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 09:11, 16 May 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.[1][2]

Function

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.[2]

Interactions

SH2B2 has been shown to interact with TrkA[3] and Cbl gene.[4][5]

References

  1. Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A (Aug 1997). "Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation". Oncogene. 15 (1): 7–15. doi:10.1038/sj.onc.1201163. PMID 9233773.
  2. 2.0 2.1 "Entrez Gene: SH2B2 SH2B adaptor protein 2".
  3. Qian X, Riccio A, Zhang Y, Ginty DD (Nov 1998). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron. 21 (5): 1017–29. doi:10.1016/S0896-6273(00)80620-0. PMID 9856458.
  4. Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A (May 1999). "APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl". Leukemia. 13 (5): 760–7. doi:10.1038/sj/leu/2401397. PMID 10374881.
  5. Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J (Mar 2008). "Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates". EMBO J. 27 (5): 804–16. doi:10.1038/emboj.2008.18. PMC 2265755. PMID 18273061.

Further reading