SFRS6

Splicing factor, arginine/serine-rich 6
Identifiers
Symbols	SFRS6 ; B52; MGC5045; SRP55
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74570
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SFRS6 208804 s at tn.png
File:PBB GE SFRS6 206108 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Splicing factor, arginine/serine-rich 6, also known as SFRS6, is a human gene.

The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12.

Further reading

• Zahler AM, Lane WS, Stolk JA, Roth MB (1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev. 6 (5): 837–47. PMID 1577277.CS1 maint: Multiple names: authors list (link)
• Screaton GR, Cáceres JF, Mayeda A; et al. (1995). "Identification and characterization of three members of the human SR family of pre-mRNA splicing factors". EMBO J. 14 (17): 4336–49. PMID 7556075.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ramchatesingh J, Zahler AM, Neugebauer KM; et al. (1995). "A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer". Mol. Cell. Biol. 15 (9): 4898–907. PMID 7651409.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gui JF, Lane WS, Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. doi:10.1038/369678a0. PMID 8208298.CS1 maint: Multiple names: authors list (link)
• Nagel RJ, Lancaster AM, Zahler AM (1998). "Specific binding of an exonic splicing enhancer by the pre-mRNA splicing factor SRp55". RNA. 4 (1): 11–23. PMID 9436904.CS1 maint: Multiple names: authors list (link)
• Liu HX, Zhang M, Krainer AR (1998). "Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins". Genes Dev. 12 (13): 1998–2012. PMID 9649504.CS1 maint: Multiple names: authors list (link)
• Lemaire R, Winne A, Sarkissian M, Lafyatis R (1999). "SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation". Eur. J. Immunol. 29 (3): 823–37. PMID 10092085.CS1 maint: Multiple names: authors list (link)
• Paillard F (1999). "A novel soluble chimera for the treatment of familial hypercholesterolemia". Hum. Gene Ther. 10 (7): 1093–4. doi:10.1089/10430349950018085. PMID 10340541.
• Barnard DC, Patton JG (2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein". Mol. Cell. Biol. 20 (9): 3049–57. PMID 10757789.
• Monsalve M, Wu Z, Adelmant G; et al. (2000). "Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1". Mol. Cell. 6 (2): 307–16. PMID 10983978.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fossey SC, Mychaleckyj JC, Pendleton JK; et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tran Q, Coleman TP, Roesser JR (2003). "Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer". Biochim. Biophys. Acta. 1625 (2): 141–52. PMID 12531473.CS1 maint: Multiple names: authors list (link)
• Tran Q, Roesser JR (2003). "SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing". Biochemistry. 42 (4): 951–7. doi:10.1021/bi026753a. PMID 12549914.
• Lai MC, Lin RI, Tarn WY (2003). "Differential effects of hyperphosphorylation on splicing factor SRp55". Biochem. J. 371 (Pt 3): 937–45. doi:10.1042/BJ20021827. PMID 12549978.CS1 maint: Multiple names: authors list (link)
• Pind MT, Watson PH (2004). "SR protein expression and CD44 splicing pattern in human breast tumours". Breast Cancer Res. Treat. 79 (1): 75–82. PMID 12779084.
• Li J, Hawkins IC, Harvey CD; et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. PMID 14559993.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)