RNF11: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''RING finger protein 11''' is a [[protein]] that in humans is encoded by the ''RNF11'' [[gene]].<ref name="pmid10673045">{{cite journal | vauthors = Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu MA, Saito T | title = Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein | journal = Biochim. Biophys. Acta | volume = 1489 | issue = 2-3 | pages = 421–7 | date = December 1999 | pmid = 10673045 | pmc =  | doi = 10.1016/s0167-4781(99)00190-6 }}</ref><ref name="pmid10810093">{{cite journal | vauthors = Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W | title = Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics | journal = Genome Res. | volume = 10 | issue = 5 | pages = 703–13  | date = August 2000 | pmid = 10810093 | pmc = 310876 | doi = 10.1101/gr.10.5.703 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RNF11 ring finger protein 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26994| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ring finger protein 11
| HGNCid = 10056
| Symbol = RNF11
| AltSymbols =; CGI-123; MGC51169; SID1669
| OMIM = 
| ECnumber = 
| Homologene = 32195
| MGIid = 1352759
| GeneAtlas_image1 = PBB_GE_RNF11_208924_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0000151 |text = ubiquitin ligase complex}}
| Process = {{GNF_GO|id=GO:0042787 |text = protein ubiquitination during ubiquitin-dependent protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26994
    | Hs_Ensembl = ENSG00000123091
    | Hs_RefseqProtein = NP_055187
    | Hs_RefseqmRNA = NM_014372
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 51474559
    | Hs_GenLoc_end = 51511798
    | Hs_Uniprot = Q9Y3C5
    | Mm_EntrezGene = 29864
    | Mm_Ensembl = ENSMUSG00000028557
    | Mm_RefseqmRNA = NM_013876
    | Mm_RefseqProtein = NP_038904
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 108950798
    | Mm_GenLoc_end = 108974915
    | Mm_Uniprot = Q9QYK7
  }}
}}
'''Ring finger protein 11''', also known as '''RNF11''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RNF11 ring finger protein 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26994| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).<ref name="entrez">{{cite web | title = Entrez Gene: RNF11 ring finger protein 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26994| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[RING finger domain]]
* [[RING finger domain]]


==References==
== Interactions ==
{{reflist|2}}


==Further reading==
RNF11 has been shown to [[Protein-protein interaction|interact]] with [[RIPK1]]<ref name=pmid19131965>{{cite journal | vauthors = Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW | title = The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling | journal = EMBO J. | volume = 28 | issue = 5 | pages = 513–22  | date = March 2009 | pmid = 19131965 | pmc = 2657574 | doi = 10.1038/emboj.2008.285 }}</ref> and [[STAMBP]].<ref name=pmid14755250>{{cite journal | vauthors = Li H, Seth A | title = An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein | journal = Oncogene | volume = 23 | issue = 10 | pages = 1801–8  | date = March 2004 | pmid = 14755250 | doi = 10.1038/sj.onc.1207319 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Burger A, Amemiya Y, Kitching R, Seth AK | title = Novel RING E3 ubiquitin ligases in breast cancer | journal = Neoplasia | volume = 8 | issue = 8 | pages = 689–95 | year = 2006 | pmid = 16925951 | pmc = 1601945 | doi = 10.1593/neo.06469 }}
| citations =
* {{cite journal | vauthors = Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S | title = Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4 | journal = Biochem. J. | volume = 351 Pt 3 | issue =  | pages = 557–65 | year = 2000 | pmid = 11042109 | pmc = 1221394 | doi = 10.1042/0264-6021:3510557 }}
*{{cite journal | author=Burger A, Amemiya Y, Kitching R, Seth AK |title=Novel RING E3 ubiquitin ligases in breast cancer. |journal=Neoplasia |volume=8 |issue= 8 |pages= 689-95 |year= 2006 |pmid= 16925951 |doi= 10.1593/neo.06469 }}
* {{cite journal | vauthors = Watanabe T, Ichihara M, Hashimoto M, Shimono K, Shimoyama Y, Nagasaka T, Murakumo Y, Murakami H, Sugiura H, Iwata H, Ishiguro N, Takahashi M | title = Characterization of gene expression induced by RET with MEN2A or MEN2B mutation | journal = Am. J. Pathol. | volume = 161 | issue = 1 | pages = 249–56 | year = 2002 | pmid = 12107109 | pmc = 1850689 | doi = 10.1016/S0002-9440(10)64176-4 }}
*{{cite journal | author=Seki N, Hattori A, Hayashi A, ''et al.'' |title=Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein. |journal=Biochim. Biophys. Acta |volume=1489 |issue= 2-3 |pages= 421-7 |year= 2000 |pmid= 10673045 |doi=  }}
* {{cite journal | vauthors = Kitching R, Wong MJ, Koehler D, Burger AM, Landberg G, Gish G, Seth A | title = The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases | journal = Biochim. Biophys. Acta | volume = 1639 | issue = 2 | pages = 104–12 | year = 2003 | pmid = 14559117 | doi = 10.1016/j.bbadis.2003.07.001 }}
*{{cite journal  | author=Lai CH, Chou CY, Ch'ang LY, ''et al.'' |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703-13 |year= 2000 |pmid= 10810093 |doi=  }}
* {{cite journal | vauthors = Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger AM, Seth A | title = The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase | journal = Br. J. Cancer | volume = 89 | issue = 8 | pages = 1538–44 | year = 2003 | pmid = 14562029 | pmc = 2394340 | doi = 10.1038/sj.bjc.6601301 }}
*{{cite journal  | author=Jolliffe CN, Harvey KF, Haines BP, ''et al.'' |title=Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. |journal=Biochem. J. |volume=351 Pt 3 |issue=  |pages= 557-65 |year= 2001 |pmid= 11042109 |doi= }}
* {{cite journal | vauthors = Li H, Seth A | title = An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein | journal = Oncogene | volume = 23 | issue = 10 | pages = 1801–8 | year = 2004 | pmid = 14755250 | doi = 10.1038/sj.onc.1207319 }}
*{{cite journal | author=Watanabe T, Ichihara M, Hashimoto M, ''et al.'' |title=Characterization of gene expression induced by RET with MEN2A or MEN2B mutation. |journal=Am. J. Pathol. |volume=161 |issue= 1 |pages= 249-56 |year= 2002 |pmid= 12107109 |doi=  }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Connor MK, Azmi PB, Subramaniam V, Li H, Seth A | title = Molecular characterization of ring finger protein 11 | journal = Mol. Cancer Res. | volume = 3 | issue = 8 | pages = 453–61 | year = 2005 | pmid = 16123141 | doi = 10.1158/1541-7786.MCR-04-0166 }}
*{{cite journal | author=Kitching R, Wong MJ, Koehler D, ''et al.'' |title=The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases. |journal=Biochim. Biophys. Acta |volume=1639 |issue= 2 |pages= 104-12 |year= 2003 |pmid= 14559117 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Subramaniam V, Li H, Wong M, ''et al.'' |title=The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. |journal=Br. J. Cancer |volume=89 |issue= 8 |pages= 1538-44 |year= 2003 |pmid= 14562029 |doi= 10.1038/sj.bjc.6601301 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Li H, Seth A |title=An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. |journal=Oncogene |volume=23 |issue= 10 |pages= 1801-8 |year= 2004 |pmid= 14755250 |doi= 10.1038/sj.onc.1207319 }}
* {{cite journal | vauthors = Anderson LR, Betarbet R, Gearing M, Gulcher J, Hicks AA, Stefánsson K, Lah JJ, Levey AI | title = PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain | journal = J. Neuropathol. Exp. Neurol. | volume = 66 | issue = 10 | pages = 955–64 | year = 2007 | pmid = 17917589 | doi = 10.1097/nen.0b013e3181567f17 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Connor MK, Azmi PB, Subramaniam V, ''et al.'' |title=Molecular characterization of ring finger protein 11. |journal=Mol. Cancer Res. |volume=3 |issue= 8 |pages= 453-61 |year= 2005 |pmid= 16123141 |doi= 10.1158/1541-7786.MCR-04-0166 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Anderson LR, Betarbet R, Gearing M, ''et al.'' |title=PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain. |journal=J. Neuropathol. Exp. Neurol. |volume=66 |issue= 10 |pages= 955-64 |year= 2007 |pmid= 17917589 |doi= 10.1097/nen.0b013e3181567f17 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|RNF11+protein,+human}}
* {{MeshName|RNF11+protein,+human}}


{{protein-stub}}
[[Category:RING finger proteins]]
{{WikiDoc Sources}}
 
 
{{gene-1-stub}}

Latest revision as of 15:52, 21 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

RING finger protein 11 is a protein that in humans is encoded by the RNF11 gene.[1][2][3]

Function

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).[3]

See also

Interactions

RNF11 has been shown to interact with RIPK1[4] and STAMBP.[5]

References

  1. ↑ Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu MA, Saito T (December 1999). "Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein". Biochim. Biophys. Acta. 1489 (2–3): 421–7. doi:10.1016/s0167-4781(99)00190-6. PMID 10673045.
  2. ↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (August 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  3. ↑ 3.0 3.1 "Entrez Gene: RNF11 ring finger protein 11".
  4. ↑ Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW (March 2009). "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling". EMBO J. 28 (5): 513–22. doi:10.1038/emboj.2008.285. PMC 2657574. PMID 19131965.
  5. ↑ Li H, Seth A (March 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250.

Further reading

External links


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