RASSF5

Ras association (RalGDS/AF-6) domain family 5
File:PBB Protein RASSF5 image.jpg PDB rendering based on 2fnf.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2fnf​
Identifiers
Symbols	RASSF5 ; MGC10823; MGC17344; Maxp1; NORE1; NORE1A; NORE1B; RAPL; RASSF3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 10296
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ras association (RalGDS/AF-6) domain family 5, also known as RASSF5, is a human gene.

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• Vavvas D, Li X, Avruch J, Zhang XF (1998). "Identification of Nore1 as a potential Ras effector". J. Biol. Chem. 273 (10): 5439–42. PMID 9488663.CS1 maint: Multiple names: authors list (link)
• Ortiz-Vega S, Khokhlatchev A, Nedwidek M; et al. (2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Khokhlatchev A, Rabizadeh S, Xavier R; et al. (2002). "Identification of a novel Ras-regulated proapoptotic pathway". Curr. Biol. 12 (4): 253–65. PMID 11864565.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tommasi S, Dammann R, Jin SG; et al. (2002). "RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1". Oncogene. 21 (17): 2713–20. doi:10.1038/sj.onc.1205365. PMID 11965544.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yao R, Wang Y, You M (2002). "Chromosome mapping and sequence variation of the murine Ras effector gene Nore1". Cytogenet. Cell Genet. 95 (1–2): 126–8. PMID 11978988.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vos MD, Martinez A, Ellis CA; et al. (2003). "The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung". J. Biol. Chem. 278 (24): 21938–43. doi:10.1074/jbc.M211019200. PMID 12676952.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Katagiri K, Maeda A, Shimonaka M, Kinashi T (2003). "RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1". Nat. Immunol. 4 (8): 741–8. doi:10.1038/ni950. PMID 12845325.CS1 maint: Multiple names: authors list (link)
• Chen J, Lui WO, Vos MD; et al. (2004). "The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas". Cancer Cell. 4 (5): 405–13. PMID 14667507.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J (2004). "Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras". Biochem. J. 381 (Pt 2): 453–62. doi:10.1042/BJ20040025. PMID 15109305.CS1 maint: Multiple names: authors list (link)
• Irimia M, Fraga MF, Sanchez-Cespedes M, Esteller M (2004). "CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer". Oncogene. 23 (53): 8695–9. doi:10.1038/sj.onc.1207914. PMID 15378027.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fujita H, Fukuhara S, Sakurai A; et al. (2005). "Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes". J. Biol. Chem. 280 (6): 5022–31. doi:10.1074/jbc.M409701200. PMID 15569673.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakamura N, Carney JA, Jin L; et al. (2005). "RASSF1A and NORE1A methylation and BRAFV600E mutations in thyroid tumors". Lab. Invest. 85 (9): 1065–75. doi:10.1038/labinvest.3700306. PMID 15980887.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Foukakis T, Au AY, Wallin G; et al. (2006). "The Ras effector NORE1A is suppressed in follicular thyroid carcinomas with a PAX8-PPARgamma fusion". J. Clin. Endocrinol. Metab. 91 (3): 1143–9. doi:10.1210/jc.2005-1372. PMID 16352687.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moshnikova A, Frye J, Shay JW; et al. (2006). "The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway". J. Biol. Chem. 281 (12): 8143–52. doi:10.1074/jbc.M511837200. PMID 16421102.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Macheiner D, Heller G, Kappel S; et al. (2006). "NORE1B, a candidate tumor suppressor, is epigenetically silenced in human hepatocellular carcinoma". J. Hepatol. 45 (1): 81–9. doi:10.1016/j.jhep.2005.12.017. PMID 16516329.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishiguro K, Avruch J, Landry A; et al. (2006). "Nore1B regulates TCR signaling via Ras and Carma1". Cell. Signal. 18 (10): 1647–54. doi:10.1016/j.cellsig.2006.01.015. PMID 16520020.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)