RAD51L1
| RAD51-like 1 (S. cerevisiae) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | RAD51L1 ; MGC34245; R51H2; RAD51B; REC2; hREC2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 50190 | ||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
RAD51-like 1 (S. cerevisiae), also known as RAD51L1, is a human gene.[1]
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed.[1]
References
Further reading
- Dreikorn K, Röhl L (1974). "Preservation and transplantation of human cadaver kidneys. Experiences with the Gamgro perfusion unit". Scand. J. Urol. Nephrol. 8 (1): 19–26. PMID 4595808.
- Rapp UR, Marshall TH (1981). "Cell surface receptors for endogenous mouse type C viral glycoproteins and epidermal growth factor: tissue distribution in vivo and possible participation in specific cell-cell interaction". J. Supramol. Struct. 14 (3): 343–52. doi:10.1002/jss.400140308. PMID 6261043.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
- Rice MC, Smith ST, Bullrich F; et al. (1997). "Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7417–22. PMID 9207106.
- Albala JS, Thelen MP, Prange C; et al. (1998). "Identification of a novel human RAD51 homolog, RAD51B". Genomics. 46 (3): 476–9. doi:10.1006/geno.1997.5062. PMID 9441753.
- Cartwright R, Dunn AM, Simpson PJ; et al. (1998). "Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family". Nucleic Acids Res. 26 (7): 1653–9. PMID 9512535.
- Havre PA, Rice MC, Noe M, Kmiec EB (1998). "The human REC2/RAD51B gene acts as a DNA damage sensor by inducing G1 delay and hypersensitivity to ultraviolet irradiation". Cancer Res. 58 (20): 4733–9. PMID 9788630.
- Peng L, Rice MC, Kmiec EB (1999). "Analysis of the human RAD51L1 promoter region and its activation by UV light". Genomics. 54 (3): 529–41. doi:10.1006/geno.1998.5536. PMID 9878257.
- Schoenmakers EF, Huysmans C, Van de Ven WJ (1999). "Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas". Cancer Res. 59 (1): 19–23. PMID 9892177.
- Ingraham SE, Lynch RA, Kathiresan S; et al. (1999). "hREC2, a RAD51-like gene, is disrupted by t(12;14) (q15;q24.1) in a uterine leiomyoma". Cancer Genet. Cytogenet. 115 (1): 56–61. PMID 10565301.
- Takata M, Sasaki MS, Sonoda E; et al. (2000). "The Rad51 paralog Rad51B promotes homologous recombinational repair". Mol. Cell. Biol. 20 (17): 6476–82. PMID 10938124.
- Miller KA, Yoshikawa DM, McConnell IR; et al. (2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem. 277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID 11744692.
- Masson JY, Tarsounas MC, Stasiak AZ; et al. (2002). "Identification and purification of two distinct complexes containing the five RAD51 paralogs". Genes Dev. 15 (24): 3296–307. doi:10.1101/gad.947001. PMID 11751635.
- Sigurdsson S, Van Komen S, Bussen W; et al. (2002). "Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange". Genes Dev. 15 (24): 3308–18. doi:10.1101/gad.935501. PMID 11751636.
- Wiese C, Collins DW, Albala JS; et al. (2002). "Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells". Nucleic Acids Res. 30 (4): 1001–8. PMID 11842112.
- Liu N, Schild D, Thelen MP, Thompson LH (2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells". Nucleic Acids Res. 30 (4): 1009–15. PMID 11842113.
- Blank C, Schoenmakers EF, Rogalla P; et al. (2002). "Intragenic breakpoint within RAD51L1 in a t(6;14)(p21.3;q24) of a pulmonary chondroid hamartoma". Cytogenet. Cell Genet. 95 (1–2): 17–9. PMID 11978964.
- Godthelp BC, Artwert F, Joenje H, Zdzienicka MZ (2002). "Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1". Oncogene. 21 (32): 5002–5. doi:10.1038/sj.onc.1205656. PMID 12118380.
- Lio YC, Mazin AV, Kowalczykowski SC, Chen DJ (2003). "Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro". J. Biol. Chem. 278 (4): 2469–78. doi:10.1074/jbc.M211038200. PMID 12427746.
- Yokoyama H, Kurumizaka H, Ikawa S; et al. (2003). "Holliday junction binding activity of the human Rad51B protein". J. Biol. Chem. 278 (4): 2767–72. doi:10.1074/jbc.M210899200. PMID 12441335.
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