Progeria causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Disease name] may be caused by [cause1], [cause2], or [cause3].
OR
Common causes of [disease] include [cause1], [cause2], and [cause3].
OR
The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].
OR
The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click here.
Causes
Life-threatening Causes
- Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of disease name, however complications resulting from untreated disease name is common.
- Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
- [Cause] is a life-threatening cause of [disease].
Common Causes
Common causes of Hutchinson-Gilford progeria syndrome (HGPS) may include:[1][2][3][4]
- Mutation in LMNA gene which results in production of abnormal protein laminin A which is also called progerin
- LMNA gene plays a very crucial role in the following:
- Membrane which surrounds the cell’s nucleus and stabilizes the nuclear membrane.
- The location of the LMNA gene is on chromosome 1.
Less Common Causes
Less common causes of [disease name] include:
- [Cause1]
- [Cause2]
- [Cause3]
Genetic Causes
- Hutchinson-Gilford progeria syndrome (HGPS) is caused by a mutation in the LMNA gene.
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
List the causes of the disease in alphabetical order:
- Cause 1
- Cause 2
- Cause 3
- Cause 4
- Cause 5
- Cause 6
- Cause 7
- Cause 8
- Cause 9
- Cause 10
References
- ↑ Elzeneini E, Wickström SA (2017). "Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis". J Cell Biol. 216 (9): 2607–2610. doi:10.1083/jcb.201707090. PMC 5584192. PMID 28811278.
- ↑ Guénantin AC, Briand N, Bidault G, Afonso P, Béréziat V, Vatier C; et al. (2014). "Nuclear envelope-related lipodystrophies". Semin Cell Dev Biol. 29: 148–57. doi:10.1016/j.semcdb.2013.12.015. PMID 24384368.
- ↑ Oldenburg A, Briand N, Sørensen AL, Cahyani I, Shah A, Moskaug JØ; et al. (2017). "A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus". J Cell Biol. 216 (9): 2731–2743. doi:10.1083/jcb.201701043. PMC 5584164. PMID 28751304.
- ↑ Camozzi D, Capanni C, Cenni V, Mattioli E, Columbaro M, Squarzoni S; et al. (2014). "Diverse lamin-dependent mechanisms interact to control chromatin dynamics. Focus on laminopathies". Nucleus. 5 (5): 427–40. doi:10.4161/nucl.36289. PMC 4164485. PMID 25482195.