Post-streptococcal glomerulonephritis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

Overview

An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].

OR

Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

OR

[Test] is usually normal for patients with [disease name].

OR

Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

There are no diagnostic laboratory findings associated with [disease name].

Laboratory Findings

• Laboratory findings consistent with the diagnosis of post-streptococcal glomerulonephritis include:
• Diagnosis of preceding streptococcal infection can be determined by measuring following antibodies:
  • The antistreptolysin (ASO) positive
  • Antinicotinamide adenine dinucleotides (anti-NAD) positive
  • Antihyaluronidase (AHase), and anti–DNAse B positive
• Renal function tests:
  • Increased levels of blood urea nitrogen (BUN)
  • Serum creatinine levels are increased
• Serologic testing:
  • Low serum concentrations of C3
• Urinalysis:
  • Proteinuria
  • Hematuria
  • Urine sediments show red blood cells, red blood cell casts, white blood cells, granular casts
  • Dysmorphic red blood cells are characteristics findings of glomerular hematuria usually detected by performing phase-contrast microscopy