Post-streptococcal glomerulonephritis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
Laboratory findings consistent with the diagnosis of streptococcal infection include antistreptolysin O (ASO) positive, antinicotinamide adenine dinucleotides positive, antihyaluronidase, and anti–DNAse B positive. Other abnormal laboratory findings include leukocytosis with neutrophilia, CRP is raised, increased levels of blood urea nitrogen (BUN) and serum creatinine levels are increased. On serologic testing, hypocomplementemia is usually found. On urinalysis, proteinuria, hematuria, and dysmorphic red cells are usually found.
Laboratory Findings
- Diagnosis of preceding streptococcal infection can be determined by measuring following antibodies:[1]
- The antistreptolysin O (ASO) positive
- Antinicotinamide adenine dinucleotides (anti-NAD) positive
- Antihyaluronidase (AHase), and anti–DNAse B positive
- CBC with differential count:[2]
- Leukocytosis with neutrophilia
- CRP is raised
- Renal function tests:
- Increased levels of blood urea nitrogen (BUN)
- Serum creatinine levels are increased
- Serologic testing:[3][4]
- Hypocomplementemia such as low serum level of C3, C4, and C5.
- Urinalysis:[5]
- Proteinuria
- Hematuria
- Urine sediments show red blood cells, red blood cell casts, white blood cells, granular casts
- Dysmorphic red blood cells are characteristics findings of glomerular hematuria
References
- ↑ Lang MM, Towers C (August 2001). "Identifying poststreptococcal glomerulonephritis". Nurse Pract. 26 (8): 34, 37–42, 44–7, quiz 48–9. PMID 11521409.
- ↑ Kılıc BD, Kara MA, Buyukcelik M, Balat A (May 2018). "Evaluation of clinical and laboratory findings in pediatric post-streptococcal glomerulonephritis". Pediatr Int. doi:10.1111/ped.13587. PMID 29729114.
- ↑ Wyatt RJ, Forristal J, West CD, Sugimoto S, Curd JG (April 1988). "Complement profiles in acute post-streptococcal glomerulonephritis". Pediatr. Nephrol. 2 (2): 219–23. PMID 3153014.
- ↑ Cameron JS, Vick RM, Ogg CS, Seymour WM, Chantler C, Turner DR (September 1973). "Plasma C3 and C4 concentrations in management of glomerulonephritis". Br Med J. 3 (5882): 668–72. PMC 1587021. PMID 4200478.
- ↑ Luo C, Chen D, Tang Z, Zhou Y, Wang J, Liu Z, Li L (September 2010). "Clinicopathological features and prognosis of Chinese patients with acute post-streptococcal glomerulonephritis". Nephrology (Carlton). 15 (6): 625–31. doi:10.1111/j.1440-1797.2010.01352.x. PMID 20883283.