Post-streptococcal glomerulonephritis laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
*Diagnosis of preceding [[streptococcal infection]] can be determined by measuring following [[antibodies]]:<ref name="pmid11521409">{{cite journal |vauthors=Lang MM, Towers C |title=Identifying poststreptococcal glomerulonephritis |journal=Nurse Pract |volume=26 |issue=8 |pages=34, 37–42, 44–7; quiz 48–9 |date=August 2001 |pmid=11521409 |doi= |url=}}</ref> | |||
*Diagnosis of preceding streptococcal infection can be determined by measuring following antibodies:<ref name="pmid11521409">{{cite journal |vauthors=Lang MM, Towers C |title=Identifying poststreptococcal glomerulonephritis |journal=Nurse Pract |volume=26 |issue=8 |pages=34, 37–42, 44–7; quiz 48–9 |date=August 2001 |pmid=11521409 |doi= |url=}}</ref> | **The [[antistreptolysin O]] (ASO) positive | ||
**The antistreptolysin (ASO) positive | |||
**Antinicotinamide adenine dinucleotides (anti-NAD) positive | **Antinicotinamide adenine dinucleotides (anti-NAD) positive | ||
**Antihyaluronidase (AHase), and anti–DNAse B positive | **Antihyaluronidase (AHase), and anti–DNAse B positive | ||
*CBC with | *[[Complete blood count|CBC]] with differential count:<ref name="pmid29729114">{{cite journal |vauthors=Kılıc BD, Kara MA, Buyukcelik M, Balat A |title=Evaluation of clinical and laboratory findings in pediatric post-streptococcal glomerulonephritis |journal=Pediatr Int |volume= |issue= |pages= |date=May 2018 |pmid=29729114 |doi=10.1111/ped.13587 |url=}}</ref> | ||
**Leukocytosis with | **[[Leukocytosis]] with [[neutrophilia]] | ||
*CRP is raised | *[[C-reactive protein|CRP]] is raised | ||
*Renal function tests: | *Renal function tests: | ||
**Increased levels of blood urea nitrogen (BUN) | **Increased levels of [[blood urea nitrogen]] (BUN) | ||
**Serum creatinine levels are increased | **[[Serum creatinine]] levels are increased | ||
*Serologic testing:<ref name="pmid3153014">{{cite journal |vauthors=Wyatt RJ, Forristal J, West CD, Sugimoto S, Curd JG |title=Complement profiles in acute post-streptococcal glomerulonephritis |journal=Pediatr. Nephrol. |volume=2 |issue=2 |pages=219–23 |date=April 1988 |pmid=3153014 |doi= |url=}}</ref><ref name="pmid4200478">{{cite journal |vauthors=Cameron JS, Vick RM, Ogg CS, Seymour WM, Chantler C, Turner DR |title=Plasma C3 and C4 concentrations in management of glomerulonephritis |journal=Br Med J |volume=3 |issue=5882 |pages=668–72 |date=September 1973 |pmid=4200478 |pmc=1587021 |doi= |url=}}</ref> | *Serologic testing:<ref name="pmid3153014">{{cite journal |vauthors=Wyatt RJ, Forristal J, West CD, Sugimoto S, Curd JG |title=Complement profiles in acute post-streptococcal glomerulonephritis |journal=Pediatr. Nephrol. |volume=2 |issue=2 |pages=219–23 |date=April 1988 |pmid=3153014 |doi= |url=}}</ref><ref name="pmid4200478">{{cite journal |vauthors=Cameron JS, Vick RM, Ogg CS, Seymour WM, Chantler C, Turner DR |title=Plasma C3 and C4 concentrations in management of glomerulonephritis |journal=Br Med J |volume=3 |issue=5882 |pages=668–72 |date=September 1973 |pmid=4200478 |pmc=1587021 |doi= |url=}}</ref> | ||
**Hypocomplementemia such as low serum level of C3, C4, and C5. | **[[Hypocomplementemia]] such as low serum level of [[C3 (complement)|C3]], C4, and [[C5]]. | ||
*Urinalysis:<ref name="pmid20883283">{{cite journal |vauthors=Luo C, Chen D, Tang Z, Zhou Y, Wang J, Liu Z, Li L |title=Clinicopathological features and prognosis of Chinese patients with acute post-streptococcal glomerulonephritis |journal=Nephrology (Carlton) |volume=15 |issue=6 |pages=625–31 |date=September 2010 |pmid=20883283 |doi=10.1111/j.1440-1797.2010.01352.x |url=}}</ref> | *Urinalysis:<ref name="pmid20883283">{{cite journal |vauthors=Luo C, Chen D, Tang Z, Zhou Y, Wang J, Liu Z, Li L |title=Clinicopathological features and prognosis of Chinese patients with acute post-streptococcal glomerulonephritis |journal=Nephrology (Carlton) |volume=15 |issue=6 |pages=625–31 |date=September 2010 |pmid=20883283 |doi=10.1111/j.1440-1797.2010.01352.x |url=}}</ref> | ||
**Proteinuria | **[[Proteinuria]] | ||
**Hematuria | **[[Hematuria]] | ||
**Urine sediments show red blood cells, red blood cell casts, white blood cells, granular casts | **Urine sediments show [[Red blood cell|red blood cells]], red blood cell casts, [[white blood cells]], granular casts | ||
**Dysmorphic red blood cells are characteristics findings of glomerular hematuria | **Dysmorphic red blood cells are characteristics findings of glomerular [[hematuria]] | ||
==References== | ==References== | ||
Revision as of 18:20, 13 June 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
OR
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
OR
[Test] is usually normal for patients with [disease name].
OR
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
OR
There are no diagnostic laboratory findings associated with [disease name].
Laboratory Findings
- Diagnosis of preceding streptococcal infection can be determined by measuring following antibodies:[1]
- The antistreptolysin O (ASO) positive
- Antinicotinamide adenine dinucleotides (anti-NAD) positive
- Antihyaluronidase (AHase), and anti–DNAse B positive
- CBC with differential count:[2]
- Leukocytosis with neutrophilia
- CRP is raised
- Renal function tests:
- Increased levels of blood urea nitrogen (BUN)
- Serum creatinine levels are increased
- Serologic testing:[3][4]
- Hypocomplementemia such as low serum level of C3, C4, and C5.
- Urinalysis:[5]
- Proteinuria
- Hematuria
- Urine sediments show red blood cells, red blood cell casts, white blood cells, granular casts
- Dysmorphic red blood cells are characteristics findings of glomerular hematuria
References
- ↑ Lang MM, Towers C (August 2001). "Identifying poststreptococcal glomerulonephritis". Nurse Pract. 26 (8): 34, 37–42, 44–7, quiz 48–9. PMID 11521409.
- ↑ Kılıc BD, Kara MA, Buyukcelik M, Balat A (May 2018). "Evaluation of clinical and laboratory findings in pediatric post-streptococcal glomerulonephritis". Pediatr Int. doi:10.1111/ped.13587. PMID 29729114.
- ↑ Wyatt RJ, Forristal J, West CD, Sugimoto S, Curd JG (April 1988). "Complement profiles in acute post-streptococcal glomerulonephritis". Pediatr. Nephrol. 2 (2): 219–23. PMID 3153014.
- ↑ Cameron JS, Vick RM, Ogg CS, Seymour WM, Chantler C, Turner DR (September 1973). "Plasma C3 and C4 concentrations in management of glomerulonephritis". Br Med J. 3 (5882): 668–72. PMC 1587021. PMID 4200478.
- ↑ Luo C, Chen D, Tang Z, Zhou Y, Wang J, Liu Z, Li L (September 2010). "Clinicopathological features and prognosis of Chinese patients with acute post-streptococcal glomerulonephritis". Nephrology (Carlton). 15 (6): 625–31. doi:10.1111/j.1440-1797.2010.01352.x. PMID 20883283.