Post-streptococcal glomerulonephritis laboratory findings: Difference between revisions
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{{Post-streptococcal glomerulonephritis}} | {{Post-streptococcal glomerulonephritis}} | ||
{{CMG}} {{AE}} {{MKK}} | |||
==Overview== | |||
Laboratory findings consistent with the diagnosis of [[streptococcal infection]] include [[antistreptolysin O]] (ASO) positive, antinicotinamide adenine dinucleotides positive, antihyaluronidase, and anti–DNAse B positive. Other abnormal laboratory findings include [[leukocytosis]] with [[neutrophilia]], [[c-reactive protein|CRP]] is raised, increased levels of [[blood urea nitrogen]] (BUN) and [[serum creatinine]] levels are increased. On serologic testing, [[hypocomplementemia]] is usually found. On urinalysis, [[proteinuria]], [[hematuria]], and dysmorphic red cells are usually found. | |||
==Laboratory Findings== | |||
*Diagnosis of preceding [[streptococcal infection]] can be determined by measuring following [[antibodies]]:<ref name="pmid11521409">{{cite journal |vauthors=Lang MM, Towers C |title=Identifying poststreptococcal glomerulonephritis |journal=Nurse Pract |volume=26 |issue=8 |pages=34, 37–42, 44–7; quiz 48–9 |date=August 2001 |pmid=11521409 |doi= |url=}}</ref> | |||
**The [[antistreptolysin O]] (ASO) positive | |||
**Antinicotinamide adenine dinucleotides (anti-NAD) positive | |||
**Antihyaluronidase (AHase), and anti–DNAse B positive | |||
*[[Complete blood count|CBC]] with differential count:<ref name="pmid29729114">{{cite journal |vauthors=Kılıc BD, Kara MA, Buyukcelik M, Balat A |title=Evaluation of clinical and laboratory findings in pediatric post-streptococcal glomerulonephritis |journal=Pediatr Int |volume= |issue= |pages= |date=May 2018 |pmid=29729114 |doi=10.1111/ped.13587 |url=}}</ref> | |||
**[[Leukocytosis]] with [[neutrophilia]] | |||
*[[C-reactive protein|CRP]] is raised | |||
*Renal function tests: | |||
**Increased levels of [[blood urea nitrogen]] (BUN) | |||
**[[Serum creatinine]] levels are increased | |||
*Serologic testing:<ref name="pmid3153014">{{cite journal |vauthors=Wyatt RJ, Forristal J, West CD, Sugimoto S, Curd JG |title=Complement profiles in acute post-streptococcal glomerulonephritis |journal=Pediatr. Nephrol. |volume=2 |issue=2 |pages=219–23 |date=April 1988 |pmid=3153014 |doi= |url=}}</ref><ref name="pmid4200478">{{cite journal |vauthors=Cameron JS, Vick RM, Ogg CS, Seymour WM, Chantler C, Turner DR |title=Plasma C3 and C4 concentrations in management of glomerulonephritis |journal=Br Med J |volume=3 |issue=5882 |pages=668–72 |date=September 1973 |pmid=4200478 |pmc=1587021 |doi= |url=}}</ref> | |||
**[[Hypocomplementemia]] such as low serum level of [[C3 (complement)|C3]], C4, and [[C5]]. | |||
*Urinalysis:<ref name="pmid20883283">{{cite journal |vauthors=Luo C, Chen D, Tang Z, Zhou Y, Wang J, Liu Z, Li L |title=Clinicopathological features and prognosis of Chinese patients with acute post-streptococcal glomerulonephritis |journal=Nephrology (Carlton) |volume=15 |issue=6 |pages=625–31 |date=September 2010 |pmid=20883283 |doi=10.1111/j.1440-1797.2010.01352.x |url=}}</ref> | |||
**[[Proteinuria]] | |||
**[[Hematuria]] | |||
**Urine sediments show [[Red blood cell|red blood cells]], red blood cell casts, [[white blood cells]], granular casts | |||
**Dysmorphic red blood cells are characteristics findings of glomerular [[hematuria]] | |||
==References== | ==References== | ||
Latest revision as of 16:43, 14 June 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
Laboratory findings consistent with the diagnosis of streptococcal infection include antistreptolysin O (ASO) positive, antinicotinamide adenine dinucleotides positive, antihyaluronidase, and anti–DNAse B positive. Other abnormal laboratory findings include leukocytosis with neutrophilia, CRP is raised, increased levels of blood urea nitrogen (BUN) and serum creatinine levels are increased. On serologic testing, hypocomplementemia is usually found. On urinalysis, proteinuria, hematuria, and dysmorphic red cells are usually found.
Laboratory Findings
- Diagnosis of preceding streptococcal infection can be determined by measuring following antibodies:[1]
- The antistreptolysin O (ASO) positive
- Antinicotinamide adenine dinucleotides (anti-NAD) positive
- Antihyaluronidase (AHase), and anti–DNAse B positive
- CBC with differential count:[2]
- Leukocytosis with neutrophilia
- CRP is raised
- Renal function tests:
- Increased levels of blood urea nitrogen (BUN)
- Serum creatinine levels are increased
- Serologic testing:[3][4]
- Hypocomplementemia such as low serum level of C3, C4, and C5.
- Urinalysis:[5]
- Proteinuria
- Hematuria
- Urine sediments show red blood cells, red blood cell casts, white blood cells, granular casts
- Dysmorphic red blood cells are characteristics findings of glomerular hematuria
References
- ↑ Lang MM, Towers C (August 2001). "Identifying poststreptococcal glomerulonephritis". Nurse Pract. 26 (8): 34, 37–42, 44–7, quiz 48–9. PMID 11521409.
- ↑ Kılıc BD, Kara MA, Buyukcelik M, Balat A (May 2018). "Evaluation of clinical and laboratory findings in pediatric post-streptococcal glomerulonephritis". Pediatr Int. doi:10.1111/ped.13587. PMID 29729114.
- ↑ Wyatt RJ, Forristal J, West CD, Sugimoto S, Curd JG (April 1988). "Complement profiles in acute post-streptococcal glomerulonephritis". Pediatr. Nephrol. 2 (2): 219–23. PMID 3153014.
- ↑ Cameron JS, Vick RM, Ogg CS, Seymour WM, Chantler C, Turner DR (September 1973). "Plasma C3 and C4 concentrations in management of glomerulonephritis". Br Med J. 3 (5882): 668–72. PMC 1587021. PMID 4200478.
- ↑ Luo C, Chen D, Tang Z, Zhou Y, Wang J, Liu Z, Li L (September 2010). "Clinicopathological features and prognosis of Chinese patients with acute post-streptococcal glomerulonephritis". Nephrology (Carlton). 15 (6): 625–31. doi:10.1111/j.1440-1797.2010.01352.x. PMID 20883283.