Plummer-Vinson syndrome laboratory findings

Plummer-Vinson syndrome Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Plummer-Vinson syndrome from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Criteria
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X Ray
Echocardiography and Ultrasound
CT
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Plummer-Vinson syndrome laboratory findings On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Plummer-Vinson syndrome laboratory findings All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Plummer-Vinson syndrome laboratory findings
CDC on Plummer-Vinson syndrome laboratory findings
Plummer-Vinson syndrome laboratory findings in the news
Blogs on Plummer-Vinson syndrome laboratory findings
Directions to Hospitals Treating Plummer-Vinson syndrome
Risk calculators and risk factors for Plummer-Vinson syndrome laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.

Laboratory Findings

Blood tests show a hypochromic microcytic anemia that is consistent with an iron-deficiency anemia. Biopsy of involved mucosa typically reveals epithelial atrophy (shrinking) and varying amounts of submucosal chronic inflammation. Epithelial atypia or dysplasia may be present.

Overview

An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].

OR

Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

OR

[Test] is usually normal among patients with [disease name].

OR

Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

There are no diagnostic laboratory findings associated with [disease name].

Laboratory Findings

Laboratory findings consistent with the diagnosis of Plummer-Vinson syndrome include presence of iron deficiency anemia:

• Complete blood count should be done in patients of Plummer-Vinson syndrome and will have the following findings:
  • Low mean corpuscular volume (MCV <80 fl)
  • Low mean corpuscular hemoglobin concentration (MCHC)
  • Elevated platelet count (platelets > 450,000/µL)
  • Normal or elevated white blood cell count

• Iron studies should be done in patients with pallor, dysphagia or esophageal webs to confirm the diagnosis of Plummer-Vinson syndrome. The tests usually done for iron deficiency anemia are:
  • Serum iron- Decreased in iron deficiency
  • Transferrin- Elevated in iron deficiency
  • Total iron binding capacity (TIBC)- Elevated in iron deficiency.
  • Transferrin saturation- derived by dividing the serum iron by the TIBC. Decreased in iron deficiency.
  • Ferritin- Indicator of body iron stores and is low in iron deficiency. However, ferritin also acts as an acute phase reactant and can be unreliable in inflammatory illness.

Change in lab values in iron deficiency anemia

Change	Parameter
Decrease	Hemoglobin, Ferritin, MCV
Increase	TIBC, Transferrin, RDW

• Peripheral smear:
  • RBCs are microcytic and hypochromic
  • Increased number of platelets
  • Target cells (can be seen in any case of anemia)

• Other test includes:
  • Stool testing
  • Blood lead levels
  • Bone marrow aspiration