Phyllodes tumor

WikiDoc Resources for Phyllodes tumor
Articles
Most recent articles on Phyllodes tumor Most cited articles on Phyllodes tumor Review articles on Phyllodes tumor Articles on Phyllodes tumor in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Phyllodes tumor Images of Phyllodes tumor Photos of Phyllodes tumor Podcasts & MP3s on Phyllodes tumor Videos on Phyllodes tumor
Evidence Based Medicine
Cochrane Collaboration on Phyllodes tumor Bandolier on Phyllodes tumor TRIP on Phyllodes tumor
Clinical Trials
Ongoing Trials on Phyllodes tumor at Clinical Trials.gov Trial results on Phyllodes tumor Clinical Trials on Phyllodes tumor at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Phyllodes tumor NICE Guidance on Phyllodes tumor NHS PRODIGY Guidance FDA on Phyllodes tumor CDC on Phyllodes tumor
Books
Books on Phyllodes tumor
News
Phyllodes tumor in the news Be alerted to news on Phyllodes tumor News trends on Phyllodes tumor
Commentary
Blogs on Phyllodes tumor
Definitions
Definitions of Phyllodes tumor
Patient Resources / Community
Patient resources on Phyllodes tumor Discussion groups on Phyllodes tumor Patient Handouts on Phyllodes tumor Directions to Hospitals Treating Phyllodes tumor Risk calculators and risk factors for Phyllodes tumor
Healthcare Provider Resources
Symptoms of Phyllodes tumor Causes & Risk Factors for Phyllodes tumor Diagnostic studies for Phyllodes tumor Treatment of Phyllodes tumor
Continuing Medical Education (CME)
CME Programs on Phyllodes tumor
International
Phyllodes tumor en Espanol Phyllodes tumor en Francais
Business
Phyllodes tumor in the Marketplace Patents on Phyllodes tumor
Experimental / Informatics
List of terms related to Phyllodes tumor

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Synonyms and keywords: Cystosarcoma phyllodes;

Overview

Phyllodes tumor (also known as cystosarcoma phyllodes), is a typically large, fast-growing mass that arises from the periductal stromal cells of the breast. Phyllodes tumors account for less than 1% of all breast neoplasms.

Historical Perspective

• Phyllodes tumor was first discovered by [scientist name], a [nationality + occupation], in [year] during/following [event].

Classification

• Phyllodes tumor may be classified according to [classification method] into [number] subtypes/groups:

• [group1]
• [group2]
• [group3]

• Other variants of phyllodes tumor include [disease subtype 1], [disease subtype 2], and [disease subtype 3].

Pathophysiology

• The pathogenesis of phyllodes tumor is characterized by [feature1], [feature2], and [feature3].
• Genes involved in the development of phyllodes tumor, include:
• On gross pathology, characteristic findings of phyllodes tumor, include:

• Cleft/leaf-like structures
• Friable mass
• Well-defined margins

• On microscopic histopathological analysis,characteristic findings of phyllodes tumor, include:

• Large slit-like spaces
• Cellular myxoid stroma
• +/-Infiltrative border
• Stromal overgrowth

Causes

• There are no established causes for phyllodes tumor.

Differentiating Phyllodes Tumor from Other Diseases

• Phyllodes tumor must be differentiated from other diseases that cause a breast mass, such as:

• [Differential dx1]
• [Differential dx2]
• [Differential dx3]

Epidemiology and Demographics

• The prevalence of phyllodes tumor is approximately [number or range] per 100,000 individuals worldwide.
• In [year], the incidence of phyllodes tumor was estimated to be [number or range] cases per 100,000 individuals in [location].

Age

• Patients of all age groups may develop phyllodes tumor.

Gender

• Females are more commonly affected with phyllodes tumor than males.

Race

• There is no racial predilection for phyllodes tumor.

Risk Factors

• Common risk factors in the development of phyllodes tumor, include:

Natural History, Complications and Prognosis

• The majority of patients with phyllodes tumor remain asymptomatic for [duration/years].
• Early clinical features include [manifestation 1], [manifestation 2], and [manifestation 3].
• If left untreated, [#%] of patients with phyllodes tumor may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
• Common complications of phyllodes tumor include [complication 1], [complication 2], and [complication 3].
• Prognosis is generally [excellent/good/poor], and the [1/5/10­year mortality/survival rate] of patients with phyllodes tumor is approximately [#%].

Diagnosis

Diagnostic Criteria

• The diagnosis of phyllodes tumor is made with biopsy.

Symptoms

• Phyllodes tumor is usually asymptomatic.
• Symptoms of phyllodes tumor may include the following:

• [symptom 1]
• [symptom 2]
• [symptom 3]
• [symptom 4]
• [symptom 5]
• [symptom 6]

Physical Examination

• Patients with phyllodes tumor usually appear [general appearance].
• Physical examination may be remarkable for:

• [finding 1]
• [finding 2]
• [finding 3]
• [finding 4]
• [finding 5]
• [finding 6]

Laboratory Findings

• There are no specific laboratory findings associated with phyllodes tumor.

• A [positive/negative] [test name] is diagnostic of phyllodes tumor.
• An [elevated/reduced] concentration of [serum/blood/urinary/CSF/other] [lab test] is diagnostic of phyllodes tumor.
• Other laboratory findings consistent with the diagnosis of phyllodes tumor include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

Imaging Findings

• [Imaging study 1] is the imaging modality of choice for phyllodes tumor.
• On [imaging study 1], findings of phyllodes tumor include:

Treatment

Medical Therapy

• The mainstay of therapy for phyllodes tumor is [medical therapy 1] and [medical therapy 2].

Surgery

• Surgery is the mainstay of therapy for phyllodes tumor.
• [Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of phyllodes tumor.
• [Surgical procedure] can only be performed for patients with [disease stage] phyllodes tumor.

Prevention

• Effective measures for the primary prevention of phyllodes tumor include periodical self-breast examination, and routine mammography.
• Once diagnosed and successfully treated, patients with phyllodes tumor are followed-up periodically.
• Follow-up testing, includes: ultrasound examination.