Peripheral arterial disease epidemiology and demographics

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AHA/ACC Guidelines on Management of Lower Extremity PAD
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Guidelines for Screening for Atherosclerotic Disease in Other Vascular Beds in patients with Lower Extremity PAD
Guidelines for Medical Therapy for Lower Extremity PAD
Guidelines for Structured Exercise Therapy for Lower Extremity PAD
Guidelines for Minimizing Tissue Loss in Lower Extremity PAD
Guidelines for Revascularization of Claudication in Lower Extremity PAD
Guidelines for Management of CLI in Lower Extremity PAD
Guidelines for Management of Acute Limb Ischemial in Lower Extremity PAD
Guidelines for Longitudinal Follow-up for Lower Extremity PAD
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Editors-in-Chief: C. Michael Gibson; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [1]

Overview

The prevalence of peripheral arterial disease in the general population is 12–14%. Peripheral arterial disease is even more common among the elderly and affects up to 20% of patients over the age of 70 years . Peripheral vascular disease affects 1 in 3 diabetics over the age of 50. Approximately 10 million Americans have peripheral arterial disease.

Age

• The incidence of peripheral arterial disease increases with increasing age
• The incidence of symptomatic PVD increases with age, from about 0.3% per year for men aged 40–55 years to about 1% per year for men aged over 75 years. The prevalence of PVD varies considerably depending on how PAD is defined, and the age of the population being studied. Diagnosis is critical, as people with PAD have a four to five times higher risk of heart attack or stroke.
• In Western Australia, the prevalence of symptomatic disease at around 60 years of age is about 5%.

The Diabetes Control and Complications Trial and U.K. Prospective Diabetes Study trials in people with type 1 and type 2 diabetes, respectively, demonstrated that glycemic control is more strongly associated with microvascular disease than macrovascular disease. It may be that pathologic changes occurring in small vessels are more sensitive to chronically elevated glucose levels than is atherosclerosis occurring in larger arteries.

References

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