Paget-Schroetter disease natural history, complications and prognosis
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Natural History, Complications, and Prognosis
Natural History
- The symptoms of Paget-Schroetter syndrome usually develop in the forth decade of life, and start with symptoms such as shoulder and upper extremity pain and swelling.
- If left untreated, up to 78% of patients with Paget-Schroetter disease may progress to develop residual upper extremity venous obstruction, also continuous symptoms and permanent disability is expected in 41% to 91% and 39% to 68% of untreated patients, respectively.[1]
Complications
- Common complications of Paget-Schroetter disease include:
- Pulmonary embolism
- Post-thrombotic syndrome[2]
- Recurrent thrombosis
- Signs and symptoms of superior vena cava syndrome
- Venous gangrene of upper extremity
- Signs and symptoms of systemic sepsis secondary to infection of thrombus
Prognosis
- Patients with early diagnosis and proper treatments usually have good prognosis.[3]
- Up to 90% of patients who received thrombolysis in combination with thoracic outlet decompression surgery experienced desirable outcomes.[4]
- Without prompt and proper treatment Paget-Schroetter disease is associated with high morbidity.[5]
- Immediate surgical intervention is related with better prognosis.[6]
References
- ↑ Illig, Karl A.; Doyle, Adam J. (2010). "A comprehensive review of Paget-Schroetter syndrome". Journal of Vascular Surgery. 51 (6): 1538–1547. doi:10.1016/j.jvs.2009.12.022. ISSN 0741-5214.
- ↑ Alla VM, Natarajan N, Kaushik M, Warrier R, Nair CK (2010). "Paget-schroetter syndrome: review of pathogenesis and treatment of effort thrombosis". West J Emerg Med. 11 (4): 358–62. PMC 2967689. PMID 21079709.
- ↑ Ibrahim, Ramy; Dashkova, Irina; Williams, Myia; Kozikowski, Andrzej; Abrol, Neeraj; Gandhi, Anjula; Pekmezaris, Renee (2017). "Paget-Schroetter syndrome in the absence of common predisposing factors: a case report". Thrombosis Journal. 15 (1). doi:10.1186/s12959-017-0146-0. ISSN 1477-9560.
- ↑ "StatPearls". 2020. PMID 29494023.
- ↑ DeLisa LC, Hensley CP, Jackson S (2017). "Diagnosis of Paget-Schroetter Syndrome/Primary Effort Thrombosis in a Recreational Weight Lifter". Phys Ther. 97 (1): 13–19. doi:10.2522/ptj.20150692. PMID 27587803.
- ↑ DeLisa LC, Hensley CP, Jackson S (2017). "Diagnosis of Paget-Schroetter Syndrome/Primary Effort Thrombosis in a Recreational Weight Lifter". Phys Ther. 97 (1): 13–19. doi:10.2522/ptj.20150692. PMID 27587803.