Paget-Schroetter disease natural history, complications and prognosis: Difference between revisions
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* Common complications of Paget-Schroetter disease include: | * Common complications of Paget-Schroetter disease include: | ||
** [[Pulmonary embolism]] | **[[Pulmonary embolism]] | ||
** [[Post-thrombotic syndrome]]<ref name="pmid21079709">{{cite journal| author=Alla VM, Natarajan N, Kaushik M, Warrier R, Nair CK| title=Paget-schroetter syndrome: review of pathogenesis and treatment of effort thrombosis. | journal=West J Emerg Med | year= 2010 | volume= 11 | issue= 4 | pages= 358-62 | pmid=21079709 | doi= | pmc=2967689 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21079709 }}</ref> | ** [[Post-thrombotic syndrome]]<ref name="pmid21079709">{{cite journal| author=Alla VM, Natarajan N, Kaushik M, Warrier R, Nair CK| title=Paget-schroetter syndrome: review of pathogenesis and treatment of effort thrombosis. | journal=West J Emerg Med | year= 2010 | volume= 11 | issue= 4 | pages= 358-62 | pmid=21079709 | doi= | pmc=2967689 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21079709 }}</ref> | ||
** Recurrent [[thrombosis]] | ** Recurrent [[thrombosis]] | ||
| Line 22: | Line 22: | ||
* Patients with early diagnosis and proper treatments usually have good [[prognosis]].<ref name="IbrahimDashkova2017">{{cite journal|last1=Ibrahim|first1=Ramy|last2=Dashkova|first2=Irina|last3=Williams|first3=Myia|last4=Kozikowski|first4=Andrzej|last5=Abrol|first5=Neeraj|last6=Gandhi|first6=Anjula|last7=Pekmezaris|first7=Renee|title=Paget-Schroetter syndrome in the absence of common predisposing factors: a case report|journal=Thrombosis Journal|volume=15|issue=1|year=2017|issn=1477-9560|doi=10.1186/s12959-017-0146-0}}</ref> | * Patients with early diagnosis and proper treatments usually have good [[prognosis]].<ref name="IbrahimDashkova2017">{{cite journal|last1=Ibrahim|first1=Ramy|last2=Dashkova|first2=Irina|last3=Williams|first3=Myia|last4=Kozikowski|first4=Andrzej|last5=Abrol|first5=Neeraj|last6=Gandhi|first6=Anjula|last7=Pekmezaris|first7=Renee|title=Paget-Schroetter syndrome in the absence of common predisposing factors: a case report|journal=Thrombosis Journal|volume=15|issue=1|year=2017|issn=1477-9560|doi=10.1186/s12959-017-0146-0}}</ref> | ||
*Up to 90% of patients who received [[thrombolysis]] in combination with [[Superior thoracic aperture|thoracic outlet]] [[decompression]] [[surgery]] experienced desirable outcomes.<ref name="pmid29494023">{{cite journal| author=| title=StatPearls | journal= | year= 2020 | volume= | issue= | pages= | pmid=29494023 | doi= | pmc= | url= }}</ref> | |||
*Without prompt and proper treatment [[Paget-Schroetter disease]] is associated with high [[morbidity]].<ref name="pmid27587803">{{cite journal| author=DeLisa LC, Hensley CP, Jackson S| title=Diagnosis of Paget-Schroetter Syndrome/Primary Effort Thrombosis in a Recreational Weight Lifter. | journal=Phys Ther | year= 2017 | volume= 97 | issue= 1 | pages= 13-19 | pmid=27587803 | doi=10.2522/ptj.20150692 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27587803 }}</ref> | |||
*Immediate surgical intervention is related with better [[prognosis]].<ref name="pmid275878032">{{cite journal| author=DeLisa LC, Hensley CP, Jackson S| title=Diagnosis of Paget-Schroetter Syndrome/Primary Effort Thrombosis in a Recreational Weight Lifter. | journal=Phys Ther | year= 2017 | volume= 97 | issue= 1 | pages= 13-19 | pmid=27587803 | doi=10.2522/ptj.20150692 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27587803 }}</ref> | |||
==References== | ==References== | ||
Revision as of 15:55, 9 June 2020
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Natural History, Complications, and Prognosis
Natural History
- The symptoms of Paget-Schroetter syndrome usually develop in the forth decade of life, and start with symptoms such as shoulder and upper extremity pain and swelling.
- If left untreated, up to 78% of patients with Paget-Schroetter disease may progress to develop residual upper extremity venous obstruction, also continuous symptoms and permanent disability is expected in 41% to 91% and 39% to 68% of untreated patients, respectively.[1]
Complications
- Common complications of Paget-Schroetter disease include:
- Pulmonary embolism
- Post-thrombotic syndrome[2]
- Recurrent thrombosis
- Signs and symptoms of superior vena cava syndrome
- Venous gangrene of upper extremity
- Signs and symptoms of systemic sepsis secondary to infection of thrombus
Prognosis
- Patients with early diagnosis and proper treatments usually have good prognosis.[3]
- Up to 90% of patients who received thrombolysis in combination with thoracic outlet decompression surgery experienced desirable outcomes.[4]
- Without prompt and proper treatment Paget-Schroetter disease is associated with high morbidity.[5]
- Immediate surgical intervention is related with better prognosis.[6]
References
- ↑ Illig, Karl A.; Doyle, Adam J. (2010). "A comprehensive review of Paget-Schroetter syndrome". Journal of Vascular Surgery. 51 (6): 1538–1547. doi:10.1016/j.jvs.2009.12.022. ISSN 0741-5214.
- ↑ Alla VM, Natarajan N, Kaushik M, Warrier R, Nair CK (2010). "Paget-schroetter syndrome: review of pathogenesis and treatment of effort thrombosis". West J Emerg Med. 11 (4): 358–62. PMC 2967689. PMID 21079709.
- ↑ Ibrahim, Ramy; Dashkova, Irina; Williams, Myia; Kozikowski, Andrzej; Abrol, Neeraj; Gandhi, Anjula; Pekmezaris, Renee (2017). "Paget-Schroetter syndrome in the absence of common predisposing factors: a case report". Thrombosis Journal. 15 (1). doi:10.1186/s12959-017-0146-0. ISSN 1477-9560.
- ↑ "StatPearls". 2020. PMID 29494023.
- ↑ DeLisa LC, Hensley CP, Jackson S (2017). "Diagnosis of Paget-Schroetter Syndrome/Primary Effort Thrombosis in a Recreational Weight Lifter". Phys Ther. 97 (1): 13–19. doi:10.2522/ptj.20150692. PMID 27587803.
- ↑ DeLisa LC, Hensley CP, Jackson S (2017). "Diagnosis of Paget-Schroetter Syndrome/Primary Effort Thrombosis in a Recreational Weight Lifter". Phys Ther. 97 (1): 13–19. doi:10.2522/ptj.20150692. PMID 27587803.