PTPRN2
| Protein tyrosine phosphatase, receptor type, N polypeptide 2 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | PTPRN2 ; IA-2beta; IAR; ICAAR; PTPRP | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 2134 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE PTPRN2 203029 s at tn.png | |||||||||||
| File:PBB GE PTPRN2 203030 s at tn.png | |||||||||||
| File:PBB GE PTPRN2 211534 x at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Protein tyrosine phosphatase, receptor type, N polypeptide 2, also known as PTPRN2, is a human gene.[1]
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.[1]
References
Further reading
- Lan MS, Lu J, Goto Y, Notkins AL (1994). "Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma". DNA Cell Biol. 13 (5): 505–14. PMID 8024693.
- Cui L, Yu WP, DeAizpurua HJ; et al. (1996). "Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes". J. Biol. Chem. 271 (40): 24817–23. PMID 8798755.
- Kawasaki E, Hutton JC, Eisenbarth GS (1996). "Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes". Biochem. Biophys. Res. Commun. 227 (2): 440–7. doi:10.1006/bbrc.1996.1526. PMID 8878534.
- Smith PD, Barker KT, Wang J; et al. (1997). "ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins". Biochem. Biophys. Res. Commun. 229 (2): 402–11. doi:10.1006/bbrc.1996.1817. PMID 8954911.
- Nagase T, Ishikawa K, Nakajima D; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. PMID 9205841.
- Li Q, Borovitskaya AE, DeSilva MG; et al. (1997). "Autoantigens in insulin-dependent diabetes mellitus: molecular cloning and characterization of human IA-2 beta". Proc. Assoc. Am. Physicians. 109 (4): 429–39. PMID 9220540.
- Schmidli RS, Colman PG, Cui L; et al. (1998). "Antibodies to the protein tyrosine phosphatases IAR and IA-2 are associated with progression to insulin-dependent diabetes (IDDM) in first-degree relatives at-risk for IDDM". Autoimmunity. 28 (1): 15–23. PMID 9754810.
- van den Maagdenberg AM, Schepens JT, Schepens MT; et al. (1999). "Assignment of Ptprn2, the gene encoding receptor-type protein tyrosine phosphatase IA-2beta, a major autoantigen in insulin-dependent diabetes mellitus, to mouse chromosome region 12F". Cytogenet. Cell Genet. 82 (3–4): 153–5. PMID 9858807.
- Berghs S, Aggujaro D, Dirkx R; et al. (2001). "betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system". J. Cell Biol. 151 (5): 985–1002. PMID 11086001.
- Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Kubosaki A, Gross S, Miura J; et al. (2004). "Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice". Diabetes. 53 (7): 1684–91. PMID 15220191.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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