PRKCQ

Protein kinase C, theta
File:PBB Protein PRKCQ image.jpg PDB rendering based on 1xjd.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1xjd​
Identifiers
Symbols	PRKCQ ; MGC126514; MGC141919; PRKCT; nPKC-theta
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21263
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PRKCQ 210039 s at tn.png
File:PBB GE PRKCQ 210038 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein kinase C, theta, also known as PRKCQ, is a human gene.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.

See also

• Protein kinase C

Further reading

• Meller N, Altman A, Isakov N (1998). "New perspectives on PKCtheta, a member of the novel subfamily of protein kinase C.". Stem Cells. 16 (3): 178–92. PMID 9617893.CS1 maint: Multiple names: authors list (link)
• Greenway AL, Holloway G, McPhee DA; et al. (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication". J. Biosci. 28 (3): 323–35. PMID 12734410.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ruegg CL, Strand M (1991). "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx". Cell. Immunol. 137 (1): 1–13. PMID 1832084.
• Chowdhury IH, Koyanagi Y, Kobayashi S; et al. (1990). "The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway". Virology. 176 (1): 126–32. PMID 1970444.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ruegg CL, Strand M (1990). "Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41". J. Immunol. 144 (10): 3928–35. PMID 2139676.
• Jakobovits A, Rosenthal A, Capon DJ (1990). "Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C.". EMBO J. 9 (4): 1165–70. PMID 2182321.CS1 maint: Multiple names: authors list (link)
• Fields AP, Bednarik DP, Hess A, May WS (1988). "Human immunodeficiency virus induces phosphorylation of its cell surface receptor". Nature. 333 (6170): 278–80. doi:10.1038/333278a0. PMID 3259291.CS1 maint: Multiple names: authors list (link)
• Chirmule N, Goonewardena H, Pahwa S; et al. (1995). "HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells". J. Biol. Chem. 270 (33): 19364–9. PMID 7642615.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chang JD, Xu Y, Raychowdhury MK, Ware JA (1993). "Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets". J. Biol. Chem. 268 (19): 14208–14. PMID 7686153.CS1 maint: Multiple names: authors list (link)
• Erdel M, Baier-Bitterlich G, Duba C; et al. (1995). "Mapping of the human protein kinase C-theta (PRKCQ) gene locus to the short arm of chromosome 10 (10p15) by FISH". Genomics. 25 (2): 595–7. PMID 7790001.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ward NE, Gravitt KR, O'Brian CA (1995). "Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein". Cancer Lett. 88 (1): 37–40. PMID 7850771.CS1 maint: Multiple names: authors list (link)
• Gupta S, Aggarwal S, Kim C, Gollapudi S (1994). "Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report". Int. J. Immunopharmacol. 16 (3): 197–204. PMID 8206685.CS1 maint: Multiple names: authors list (link)
• Baier G, Telford D, Giampa L; et al. (1993). "Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells". J. Biol. Chem. 268 (7): 4997–5004. PMID 8444877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Parada NA, Cruikshank WW, Danis HL; et al. (1996). "IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C.". Cell. Immunol. 168 (1): 100–6. doi:10.1006/cimm.1996.0054. PMID 8599832.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Conant K, Ma M, Nath A, Major EO (1996). "Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes". J. Virol. 70 (3): 1384–9. PMID 8627654.CS1 maint: Multiple names: authors list (link)
• Smith BL, Krushelnycky BW, Mochly-Rosen D, Berg P (1996). "The HIV nef protein associates with protein kinase C theta". J. Biol. Chem. 271 (28): 16753–7. PMID 8663223.CS1 maint: Multiple names: authors list (link)
• Meller N, Liu YC, Collins TL; et al. (1996). "Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function". Mol. Cell. Biol. 16 (10): 5782–91. PMID 8816492.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holmes AM (1996). "In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46". Arch. Biochem. Biophys. 335 (1): 8–12. doi:10.1006/abbi.1996.0476. PMID 8914829.
• Monks CR, Kupfer H, Tamir I; et al. (1997). "Selective modulation of protein kinase C-theta during T-cell activation". Nature. 385 (6611): 83–6. doi:10.1038/385083a0. PMID 8985252.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Datta R, Kojima H, Yoshida K, Kufe D (1997). "Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis". J. Biol. Chem. 272 (33): 20317–20. PMID 9252332.CS1 maint: Multiple names: authors list (link)