PLXNB2: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Plexin-B2''' is a [[protein]] that in humans is encoded by the ''PLXNB2'' [[gene]].<ref name="pmid10520995">{{cite journal | vauthors = Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM | title = Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates | journal = Cell | volume = 99 | issue = 1 | pages = 71–80 | date = Oct 1999 | pmid = 10520995 | pmc =  | doi = 10.1016/S0092-8674(00)80063-X }}</ref><ref name="pmid12183458">{{cite journal | vauthors = Perrot V, Vazquez-Prado J, Gutkind JS | title = Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF | journal = J Biol Chem | volume = 277 | issue = 45 | pages = 43115–20 | date = Nov 2002 | pmid = 12183458 | pmc = | doi = 10.1074/jbc.M206005200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLXNB2 plexin B2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23654| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Plexin B2
| HGNCid = 9104
| Symbol = PLXNB2
| AltSymbols =; MM1; KIAA0315; Nbla00445; PLEXB2; dJ402G11.3
| OMIM = 604293
| ECnumber = 
| Homologene = 66630
| MGIid = 2154239
| GeneAtlas_image1 = PBB_GE_PLXNB2_208890_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0050772 |text = positive regulation of axonogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23654
    | Hs_Ensembl = ENSG00000196576
    | Hs_RefseqProtein = XP_371474
    | Hs_RefseqmRNA = XM_371474
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 49055535
    | Hs_GenLoc_end = 49071150
    | Hs_Uniprot = O15031
    | Mm_EntrezGene = 140570
    | Mm_Ensembl = ENSMUSG00000036606
    | Mm_RefseqmRNA = XM_001002428
    | Mm_RefseqProtein = XP_001002428
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 88983315
    | Mm_GenLoc_end = 88995780
    | Mm_Uniprot = 
  }}
}}
'''Plexin B2''', also known as '''PLXNB2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLXNB2 plexin B2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23654| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002)).[supplied by OMIM]<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002)).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PLXNB2 plexin B2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23654| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PLXNB2 has been shown to [[Protein-protein interaction|interact]] with [[ARHGEF11]].<ref name=pmid12183458 /><ref name=pmid12123608>{{cite journal | vauthors = Swiercz JM, Kuner R, Behrens J, Offermanns S | title = Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology | journal = Neuron | volume = 35 | issue = 1 | pages = 51–63 | date = Jul 2002 | pmid = 12123608 | doi = 10.1016/S0896-6273(02)00750-X }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Shinoura N, Shamraj OI, Hugenholz H, Zhu JG, McBlack P, Warnick R, Tew JJ, Wani MA, Menon AG | title = Identification and partial sequence of a cDNA that is differentially expressed in human brain tumors | journal = Cancer Lett. | volume = 89 | issue = 2 | pages = 215–21 | year = 1995 | pmid = 7889532 | doi = 10.1016/0304-3835(95)03690-X }}
| citations =
* {{cite journal | vauthors = Trofatter JA, Long KR, Murrell JR, Stotler CJ, Gusella JF, Buckler AJ | title = An expression-independent catalog of genes from human chromosome 22 | journal = Genome Res. | volume = 5 | issue = 3 | pages = 214–24 | year = 1996 | pmid = 8593609 | doi = 10.1101/gr.5.3.214 }}
*{{cite journal | author=Shinoura N, Shamraj OI, Hugenholz H, ''et al.'' |title=Identification and partial sequence of a cDNA that is differentially expressed in human brain tumors. |journal=Cancer Lett. |volume=89 |issue= 2 |pages= 215-21 |year= 1995 |pmid= 7889532 |doi= }}
* {{cite journal | vauthors = Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res. | volume = 4 | issue = 2 | pages = 141–50 | year = 1997 | pmid = 9205841 | doi = 10.1093/dnares/4.2.141 }}
*{{cite journal | author=Trofatter JA, Long KR, Murrell JR, ''et al.'' |title=An expression-independent catalog of genes from human chromosome 22. |journal=Genome Res. |volume=5 |issue= 3 |pages= 214-24 |year= 1996 |pmid= 8593609 |doi= }}
* {{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | year = 1999 | pmid = 10591208 | doi = 10.1038/990031 }}
*{{cite journal | author=Nagase T, Ishikawa K, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141-50 |year= 1997 |pmid= 9205841 |doi= }}
* {{cite journal | vauthors = Artigiani S, Barberis D, Fazzari P, Longati P, Angelini P, van de Loo JW, Comoglio PM, Tamagnone L | title = Functional regulation of semaphorin receptors by proprotein convertases | journal = J. Biol. Chem. | volume = 278 | issue = 12 | pages = 10094–101 | year = 2003 | pmid = 12533544 | doi = 10.1074/jbc.M210156200 }}
*{{cite journal  | author=Tamagnone L, Artigiani S, Chen H, ''et al.'' |title=Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. |journal=Cell |volume=99 |issue= 1 |pages= 71-80 |year= 1999 |pmid= 10520995 |doi=  }}
* {{cite journal | vauthors = Oinuma I, Katoh H, Harada A, Negishi M | title = Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells | journal = J. Biol. Chem. | volume = 278 | issue = 28 | pages = 25671–7 | year = 2003 | pmid = 12730235 | doi = 10.1074/jbc.M303047200 }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
* {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nat. Biotechnol. | volume = 22 | issue = 6 | pages = 707–16 | year = 2005 | pmid = 15146197 | doi = 10.1038/nbt971 }}
*{{cite journal | author=Perrot V, Vazquez-Prado J, Gutkind JS |title=Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43115-20 |year= 2003 |pmid= 12183458 |doi= 10.1074/jbc.M206005200 }}
* {{cite journal | vauthors = Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S | title = Interplay between scatter factor receptors and B plexins controls invasive growth | journal = Oncogene | volume = 23 | issue = 30 | pages = 5131–7 | year = 2004 | pmid = 15184888 | doi = 10.1038/sj.onc.1207650 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T | title = Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries | journal = DNA Res. | volume = 12 | issue = 2 | pages = 117–26 | year = 2007 | pmid = 16303743 | doi = 10.1093/dnares/12.2.117 }}
*{{cite journal  | author=Artigiani S, Barberis D, Fazzari P, ''et al.'' |title=Functional regulation of semaphorin receptors by proprotein convertases. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10094-101 |year= 2003 |pmid= 12533544 |doi= 10.1074/jbc.M210156200 }}
*{{cite journal | author=Oinuma I, Katoh H, Harada A, Negishi M |title=Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25671-7 |year= 2003 |pmid= 12730235 |doi= 10.1074/jbc.M303047200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Conrotto P, Corso S, Gamberini S, ''et al.'' |title=Interplay between scatter factor receptors and B plexins controls invasive growth. |journal=Oncogene |volume=23 |issue= 30 |pages= 5131-7 |year= 2004 |pmid= 15184888 |doi= 10.1038/sj.onc.1207650 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
}}
{{refend}}
{{refend}}


{{gene-22-stub}}
{{gene-22-stub}}
{{WikiDoc Sources}}

Latest revision as of 02:28, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Plexin-B2 is a protein that in humans is encoded by the PLXNB2 gene.[1][2][3]

Function

Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002)).[supplied by OMIM][3]

Interactions

PLXNB2 has been shown to interact with ARHGEF11.[2][4]

References

  1. ↑ Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (Oct 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
  2. ↑ 2.0 2.1 Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J Biol Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
  3. ↑ 3.0 3.1 "Entrez Gene: PLXNB2 plexin B2".
  4. ↑ Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.

Further reading

  • Shinoura N, Shamraj OI, Hugenholz H, Zhu JG, McBlack P, Warnick R, Tew JJ, Wani MA, Menon AG (1995). "Identification and partial sequence of a cDNA that is differentially expressed in human brain tumors". Cancer Lett. 89 (2): 215–21. doi:10.1016/0304-3835(95)03690-X. PMID 7889532.
  • Trofatter JA, Long KR, Murrell JR, Stotler CJ, Gusella JF, Buckler AJ (1996). "An expression-independent catalog of genes from human chromosome 22". Genome Res. 5 (3): 214–24. doi:10.1101/gr.5.3.214. PMID 8593609.
  • Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  • Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  • Artigiani S, Barberis D, Fazzari P, Longati P, Angelini P, van de Loo JW, Comoglio PM, Tamagnone L (2003). "Functional regulation of semaphorin receptors by proprotein convertases". J. Biol. Chem. 278 (12): 10094–101. doi:10.1074/jbc.M210156200. PMID 12533544.
  • Oinuma I, Katoh H, Harada A, Negishi M (2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
  • Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S (2004). "Interplay between scatter factor receptors and B plexins controls invasive growth". Oncogene. 23 (30): 5131–7. doi:10.1038/sj.onc.1207650. PMID 15184888.
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.


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