PLCE1

Phospholipase C, epsilon 1
File:PBB Protein PLCE1 image.jpg PDB rendering based on 2bye.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2bye​, 2byf​, 2c5l​
Identifiers
Symbols	PLCE1 ; PLCE; FLJ23659; KIAA1516; NPHS3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 9478
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PLCE1 205111 s at tn.png
File:PBB GE PLCE1 205112 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Phospholipase C, epsilon 1, also known as PLCE1, is a human gene.

PLCE1 belongs to the phospholipase family that catalyzes the hydrolysis of polyphosphoinositides such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) to generate the second messengers Ins(1,4,5)P3 and diacylglycerol. These products initiate a cascade of intracellular responses that result in cell growth and differentiation and gene expression.[supplied by OMIM]

Further reading

• Jefferson JA, Shankland SJ (2007). "Familial nephrotic syndrome: PLCE1 enters the fray". Nephrol. Dial. Transplant. 22 (7): 1849–52. doi:10.1093/ndt/gfm098. PMID 17449496.
• Cefai D, Debre P, Kaczorek M; et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. PMID 1979339.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zauli G, Previati M, Caramelli E; et al. (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700. PMID 7589147.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. PMID 9278385.CS1 maint: Multiple names: authors list (link)
• Mayne M, Bratanich AC, Chen P; et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. PMID 9730685.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. PMID 10501179.CS1 maint: Multiple names: authors list (link)
• Nagase T, Kikuno R, Ishikawa K; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. PMID 10819331.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. PMID 10843712.CS1 maint: Multiple names: authors list (link)
• Lopez I, Mak EC, Ding J; et al. (2001). "A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway". J. Biol. Chem. 276 (4): 2758–65. doi:10.1074/jbc.M008119200. PMID 11022047.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Song C, Hu CD, Masago M; et al. (2001). "Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras". J. Biol. Chem. 276 (4): 2752–7. doi:10.1074/jbc.M008324200. PMID 11022048.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jin TG, Satoh T, Liao Y; et al. (2001). "Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling". J. Biol. Chem. 276 (32): 30301–7. doi:10.1074/jbc.M103530200. PMID 11395506.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schmidt M, Evellin S, Weernink PA; et al. (2001). "A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase". Nat. Cell Biol. 3 (11): 1020–4. doi:10.1038/ncb1101-1020. PMID 11715024.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Evellin S, Nolte J, Tysack K; et al. (2002). "Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B". J. Biol. Chem. 277 (19): 16805–13. doi:10.1074/jbc.M112024200. PMID 11877431.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Song C, Satoh T, Edamatsu H; et al. (2002). "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon". Oncogene. 21 (53): 8105–13. doi:10.1038/sj.onc.1206003. PMID 12444546.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. PMID 12482669.CS1 maint: Multiple names: authors list (link)
• Czyzyk J, Brogdon JL, Badou A; et al. (2003). "Activation of CD4 T cells by Raf-independent effectors of Ras". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6003–8. doi:10.1073/pnas.1031494100. PMID 12721365.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lennartsson J, Wernstedt C, Engström U; et al. (2003). "Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk". Exp. Cell Res. 288 (1): 110–8. PMID 12878163.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• vom Dorp F, Sari AY, Sanders H; et al. (2005). "Inhibition of phospholipase C-epsilon by Gi-coupled receptors". Cell. Signal. 16 (8): 921–8. doi:10.1016/j.cellsig.2004.01.009. PMID 15157671.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)