PEX14
| Peroxisomal biogenesis factor 14 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | PEX14 ; MGC12767; NAPP2; Pex14p; dJ734G22.2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 37936 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE PEX14 33760 at tn.png | |||||||||||
| File:PBB GE PEX14 203503 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Peroxisomal biogenesis factor 14, also known as PEX14, is a human gene.[1]
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.[1]
References
Further reading
- Albertini M, Rehling P, Erdmann R; et al. (1997). "Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways". Cell. 89 (1): 83–92. PMID 9094717.
- Huhse B, Rehling P, Albertini M; et al. (1998). "Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery". J. Cell Biol. 140 (1): 49–60. PMID 9425153.
- Fransen M, Terlecky SR, Subramani S (1998). "Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8087–92. PMID 9653144.
- Will GK, Soukupova M, Hong X; et al. (1999). "Identification and characterization of the human orthologue of yeast Pex14p". Mol. Cell. Biol. 19 (3): 2265–77. PMID 10022913.
- Girzalsky W, Rehling P, Stein K; et al. (1999). "Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes". J. Cell Biol. 144 (6): 1151–62. PMID 10087260.
- Shimizu N, Itoh R, Hirono Y; et al. (1999). "The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis". J. Biol. Chem. 274 (18): 12593–604. PMID 10212238.
- Sacksteder KA, Jones JM, South ST; et al. (2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". J. Cell Biol. 148 (5): 931–44. PMID 10704444.
- Gavva NR, Wen SC, Daftari P; et al. (2002). "NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor". Genomics. 79 (3): 423–31. doi:10.1006/geno.2002.6714. PMID 11863372.
- Otera H, Setoguchi K, Hamasaki M; et al. (2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Mol. Cell. Biol. 22 (6): 1639–55. PMID 11865044.
- Alland L, David G, Shen-Li H; et al. (2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Mol. Cell. Biol. 22 (8): 2743–50. PMID 11909966.
- Fransen M, Brees C, Ghys K; et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Mol. Cell Proteomics. 1 (3): 243–52. PMID 12096124.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Oliveira ME, Reguenga C, Gouveia AM; et al. (2003). "Mammalian Pex14p: membrane topology and characterisation of the Pex14p-Pex14p interaction". Biochim. Biophys. Acta. 1567 (1–2): 13–22. PMID 12488033.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Fransen M, Vastiau I, Brees C; et al. (2004). "Potential role for Pex19p in assembly of PTS-receptor docking complexes". J. Biol. Chem. 279 (13): 12615–24. doi:10.1074/jbc.M304941200. PMID 14715663.
- Shimozawa N, Tsukamoto T, Nagase T; et al. (2004). "Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene". Hum. Mutat. 23 (6): 552–8. doi:10.1002/humu.20032. PMID 15146459.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
- Nguyen T, Bjorkman J, Paton BC, Crane DI (2006). "Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance". J. Cell. Sci. 119 (Pt 4): 636–45. doi:10.1242/jcs.02776. PMID 16449325.
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