Ovarian germ cell tumor epidemiology and demographics: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
No edit summary
Line 6: Line 6:
==Epidemiology and Demographics==
==Epidemiology and Demographics==
===Incidence===
===Incidence===
*In USA the age-adjusted incidence of MOGCTs is 0.41 per 100,000 women.<ref name="PectasidesPectasides2008">{{cite journal|last1=Pectasides|first1=D.|last2=Pectasides|first2=E.|last3=Kassanos|first3=D.|title=Germ cell tumors of the ovary|journal=Cancer Treatment Reviews|volume=34|issue=5|year=2008|pages=427–441|issn=03057372|doi=10.1016/j.ctrv.2008.02.002}}</ref>
*In USA the age-adjusted [[incidence]] of [[malignant]] [[ovarian]] [[germ cell]] [[tumor]] is 0.41 per 100,000 women.<ref name="PectasidesPectasides2008">{{cite journal|last1=Pectasides|first1=D.|last2=Pectasides|first2=E.|last3=Kassanos|first3=D.|title=Germ cell tumors of the ovary|journal=Cancer Treatment Reviews|volume=34|issue=5|year=2008|pages=427–441|issn=03057372|doi=10.1016/j.ctrv.2008.02.002}}</ref>
*These tumors are less common than ovarian epithelial tumors.
*These [[tumors]] are less common than [[ovarian]] [[epithelial]] [[tumors]].
===Mature teratoma===
===Mature teratoma===
*The incidence of mature/benign teratoma is between 1.2 to 14.2 cases per 100,000 individuals worldwide.<ref name="pmid3166898">{{cite journal |vauthors=Westhoff C, Pike M, Vessey M |title=Benign ovarian teratomas: a population-based case-control study |journal=Br. J. Cancer |volume=58 |issue=1 |pages=93–8 |date=July 1988 |pmid=3166898 |pmc=2246492 |doi= |url=}}</ref>
*The [[incidence]] of mature/[[benign]] teratoma is between 1.2 to 14.2 cases per 100,000 individuals worldwide.<ref name="pmid3166898">{{cite journal |vauthors=Westhoff C, Pike M, Vessey M |title=Benign ovarian teratomas: a population-based case-control study |journal=Br. J. Cancer |volume=58 |issue=1 |pages=93–8 |date=July 1988 |pmid=3166898 |pmc=2246492 |doi= |url=}}</ref>
*The germ cell tumors of the ovary consist approximately one-fourth of ovarian neoplasms and a great majority of them are benign.
*The [[germ cell]] [[tumors]] of the [[ovary]] consist approximately one-fourth of [[ovarian]] [[neoplasms]] and a great majority of them are [[benign]].
===Dysgerminoma===
===Dysgerminoma===
*Age-adjusted incidence of this tumor is 0.109 per 100,000 women-year.<ref name="SmithBerwick2006">{{cite journal|last1=Smith|first1=Harriet O.|last2=Berwick|first2=Marianne|last3=Verschraegen|first3=Claire F.|last4=Wiggins|first4=Charles|last5=Lansing|first5=Letitia|last6=Muller|first6=Carolyn Y.|last7=Qualls|first7=Clifford R.|title=Incidence and Survival Rates for Female Malignant Germ Cell Tumors|journal=Obstetrics & Gynecology|volume=107|issue=5|year=2006|pages=1075–1085|issn=0029-7844|doi=10.1097/01.AOG.0000216004.22588.ce}}</ref>
*Age-adjusted [[incidence]] of this [[tumor]] is 0.109 per 100,000 women-year.<ref name="SmithBerwick2006">{{cite journal|last1=Smith|first1=Harriet O.|last2=Berwick|first2=Marianne|last3=Verschraegen|first3=Claire F.|last4=Wiggins|first4=Charles|last5=Lansing|first5=Letitia|last6=Muller|first6=Carolyn Y.|last7=Qualls|first7=Clifford R.|title=Incidence and Survival Rates for Female Malignant Germ Cell Tumors|journal=Obstetrics & Gynecology|volume=107|issue=5|year=2006|pages=1075–1085|issn=0029-7844|doi=10.1097/01.AOG.0000216004.22588.ce}}</ref>
*The incidence is greater in those with partial or complete gonadal dysgenesis.<ref name="ShaabanRezvani2014">{{cite journal|last1=Shaaban|first1=Akram M.|last2=Rezvani|first2=Maryam|last3=Elsayes|first3=Khaled M.|last4=Baskin|first4=Henry|last5=Mourad|first5=Amr|last6=Foster|first6=Bryan R.|last7=Jarboe|first7=Elke A.|last8=Menias|first8=Christine O.|title=Ovarian Malignant Germ Cell Tumors: Cellular Classification and Clinical and Imaging Features|journal=RadioGraphics|volume=34|issue=3|year=2014|pages=777–801|issn=0271-5333|doi=10.1148/rg.343130067}}</ref>
*The [[incidence]] is greater in those with partial or complete [[gonadal dysgenesis]].<ref name="ShaabanRezvani2014">{{cite journal|last1=Shaaban|first1=Akram M.|last2=Rezvani|first2=Maryam|last3=Elsayes|first3=Khaled M.|last4=Baskin|first4=Henry|last5=Mourad|first5=Amr|last6=Foster|first6=Bryan R.|last7=Jarboe|first7=Elke A.|last8=Menias|first8=Christine O.|title=Ovarian Malignant Germ Cell Tumors: Cellular Classification and Clinical and Imaging Features|journal=RadioGraphics|volume=34|issue=3|year=2014|pages=777–801|issn=0271-5333|doi=10.1148/rg.343130067}}</ref>
===Yolk sac tumor===
===Yolk sac tumor===
*Age-adjusted incidence of this tumor is 0.048 per 100,000 women-year.<ref name="SmithBerwick2006">{{cite journal|last1=Smith|first1=Harriet O.|last2=Berwick|first2=Marianne|last3=Verschraegen|first3=Claire F.|last4=Wiggins|first4=Charles|last5=Lansing|first5=Letitia|last6=Muller|first6=Carolyn Y.|last7=Qualls|first7=Clifford R.|title=Incidence and Survival Rates for Female Malignant Germ Cell Tumors|journal=Obstetrics & Gynecology|volume=107|issue=5|year=2006|pages=1075–1085|issn=0029-7844|doi=10.1097/01.AOG.0000216004.22588.ce}}</ref>
*Age-adjusted [[incidence]] of this [[tumor]] is 0.048 per 100,000 women-year.<ref name="SmithBerwick2006">{{cite journal|last1=Smith|first1=Harriet O.|last2=Berwick|first2=Marianne|last3=Verschraegen|first3=Claire F.|last4=Wiggins|first4=Charles|last5=Lansing|first5=Letitia|last6=Muller|first6=Carolyn Y.|last7=Qualls|first7=Clifford R.|title=Incidence and Survival Rates for Female Malignant Germ Cell Tumors|journal=Obstetrics & Gynecology|volume=107|issue=5|year=2006|pages=1075–1085|issn=0029-7844|doi=10.1097/01.AOG.0000216004.22588.ce}}</ref>
===Embryonal carcinoma===
===Embryonal carcinoma===
*Age-adjusted incidence of this tumor is 0.014 per 100,000 women-year.<ref name="SmithBerwick2006">{{cite journal|last1=Smith|first1=Harriet O.|last2=Berwick|first2=Marianne|last3=Verschraegen|first3=Claire F.|last4=Wiggins|first4=Charles|last5=Lansing|first5=Letitia|last6=Muller|first6=Carolyn Y.|last7=Qualls|first7=Clifford R.|title=Incidence and Survival Rates for Female Malignant Germ Cell Tumors|journal=Obstetrics & Gynecology|volume=107|issue=5|year=2006|pages=1075–1085|issn=0029-7844|doi=10.1097/01.AOG.0000216004.22588.ce}}</ref>
*Age-adjusted [[incidence]] of this [[tumor]] is 0.014 per 100,000 women-year.<ref name="SmithBerwick2006">{{cite journal|last1=Smith|first1=Harriet O.|last2=Berwick|first2=Marianne|last3=Verschraegen|first3=Claire F.|last4=Wiggins|first4=Charles|last5=Lansing|first5=Letitia|last6=Muller|first6=Carolyn Y.|last7=Qualls|first7=Clifford R.|title=Incidence and Survival Rates for Female Malignant Germ Cell Tumors|journal=Obstetrics & Gynecology|volume=107|issue=5|year=2006|pages=1075–1085|issn=0029-7844|doi=10.1097/01.AOG.0000216004.22588.ce}}</ref>
===Choriocarcinom===
===Choriocarcinom===
*Age-adjusted incidence of this tumor is 0.008 per 100,000 women-year.<ref name="SmithBerwick2006">{{cite journal|last1=Smith|first1=Harriet O.|last2=Berwick|first2=Marianne|last3=Verschraegen|first3=Claire F.|last4=Wiggins|first4=Charles|last5=Lansing|first5=Letitia|last6=Muller|first6=Carolyn Y.|last7=Qualls|first7=Clifford R.|title=Incidence and Survival Rates for Female Malignant Germ Cell Tumors|journal=Obstetrics & Gynecology|volume=107|issue=5|year=2006|pages=1075–1085|issn=0029-7844|doi=10.1097/01.AOG.0000216004.22588.ce}}</ref>
*Age-adjusted [[incidence]] of this [[tumor]] is 0.008 per 100,000 women-year.<ref name="SmithBerwick2006">{{cite journal|last1=Smith|first1=Harriet O.|last2=Berwick|first2=Marianne|last3=Verschraegen|first3=Claire F.|last4=Wiggins|first4=Charles|last5=Lansing|first5=Letitia|last6=Muller|first6=Carolyn Y.|last7=Qualls|first7=Clifford R.|title=Incidence and Survival Rates for Female Malignant Germ Cell Tumors|journal=Obstetrics & Gynecology|volume=107|issue=5|year=2006|pages=1075–1085|issn=0029-7844|doi=10.1097/01.AOG.0000216004.22588.ce}}</ref>
===Prevalence===
===Prevalence===
===Mature teratoma===
===Mature teratoma===
*Mature teratoma is the most common ovarian germ cell tumor tumor and accounts for 95% of ovarian teratomas.<ref name="Ulbright2005">{{cite journal|last1=Ulbright|first1=Thomas M|title=Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues|journal=Modern Pathology|volume=18|year=2005|pages=S61–S79|issn=0893-3952|doi=10.1038/modpathol.3800310}}</ref>
*Mature teratoma is the most common [[Ovary|ovarian]] [[germ cell]] [[tumor]] and accounts for 95% of [[ovarian]] teratomas.<ref name="Ulbright2005">{{cite journal|last1=Ulbright|first1=Thomas M|title=Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues|journal=Modern Pathology|volume=18|year=2005|pages=S61–S79|issn=0893-3952|doi=10.1038/modpathol.3800310}}</ref>
===Dysgerminoma===
===Dysgerminoma===
*Dysgerminoma is the second most common ovarian germ cell tumor.<ref name="Ulbright2005">{{cite journal|last1=Ulbright|first1=Thomas M|title=Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues|journal=Modern Pathology|volume=18|year=2005|pages=S61–S79|issn=0893-3952|doi=10.1038/modpathol.3800310}}</ref>
*Dysgerminoma is the second most common [[ovarian]] [[germ cell]] [[tumor]].<ref name="Ulbright2005">{{cite journal|last1=Ulbright|first1=Thomas M|title=Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues|journal=Modern Pathology|volume=18|year=2005|pages=S61–S79|issn=0893-3952|doi=10.1038/modpathol.3800310}}</ref>
*This tumor accounts for less than 1% of all ovarian cancers.<ref name="VicusBeiner2010">{{cite journal|last1=Vicus|first1=Danielle|last2=Beiner|first2=Mario E.|last3=Klachook|first3=Shany|last4=Le|first4=Lisa W.|last5=Laframboise|first5=Stephane|last6=Mackay|first6=Helen|title=Pure dysgerminoma of the ovary 35 years on: A single institutional experience|journal=Gynecologic Oncology|volume=117|issue=1|year=2010|pages=23–26|issn=00908258|doi=10.1016/j.ygyno.2009.12.024}}</ref>
*This [[tumor]] accounts for less than 1% of all [[ovarian]] [[cancers]].<ref name="VicusBeiner2010">{{cite journal|last1=Vicus|first1=Danielle|last2=Beiner|first2=Mario E.|last3=Klachook|first3=Shany|last4=Le|first4=Lisa W.|last5=Laframboise|first5=Stephane|last6=Mackay|first6=Helen|title=Pure dysgerminoma of the ovary 35 years on: A single institutional experience|journal=Gynecologic Oncology|volume=117|issue=1|year=2010|pages=23–26|issn=00908258|doi=10.1016/j.ygyno.2009.12.024}}</ref>
===Mixed germ cell tumor===
===Mixed germ cell tumor===
* These tumors accounts for 10% to 20% of malignant ovarian germ cell tumors and are the forth most common tumors. <ref name="Tewari2000">{{cite journal|last1=Tewari|first1=K|title=Malignant germ cell tumors of the ovary|journal=Obstetrics & Gynecology|volume=95|issue=1|year=2000|pages=128–133|issn=00297844|doi=10.1016/S0029-7844(99)00470-6}}</ref>
* These [[tumors]] accounts for 10% to 20% of [[malignant]] [[ovarian]] [[germ cell]] [[tumors]] and are the forth most common [[tumors]]. <ref name="Tewari2000">{{cite journal|last1=Tewari|first1=K|title=Malignant germ cell tumors of the ovary|journal=Obstetrics & Gynecology|volume=95|issue=1|year=2000|pages=128–133|issn=00297844|doi=10.1016/S0029-7844(99)00470-6}}</ref>
* The majority of them contain yolk sca tumor as one of the elements.
* The majority of them contain yolk sac [[tumor]] as one of the elements.
===Embryonal carcinoma===
===Embryonal carcinoma===
* These tumors are very rare, comprising only 1% of ovarian germ cell tumors, and usually are a component of mixed germ cell tumors.<ref name="ChengZhang2010">{{cite journal|last1=Cheng|first1=Liang|last2=Zhang|first2=Shaobo|last3=Talerman|first3=Aleksander|last4=Roth|first4=Lawrence M.|title=Morphologic, immunohistochemical, and fluorescence in situ hybridization study of ovarian embryonal carcinoma with comparison to solid variant of yolk sac tumor and immature teratoma|journal=Human Pathology|volume=41|issue=5|year=2010|pages=716–723|issn=00468177|doi=10.1016/j.humpath.2009.10.016}}</ref>
* These [[tumors]] are very rare, comprising only 1% of [[ovarian]] [[Germ cells|germ cell]] [[tumors]], and usually are a component of mixed [[germ cell]] [[tumors]].<ref name="ChengZhang2010">{{cite journal|last1=Cheng|first1=Liang|last2=Zhang|first2=Shaobo|last3=Talerman|first3=Aleksander|last4=Roth|first4=Lawrence M.|title=Morphologic, immunohistochemical, and fluorescence in situ hybridization study of ovarian embryonal carcinoma with comparison to solid variant of yolk sac tumor and immature teratoma|journal=Human Pathology|volume=41|issue=5|year=2010|pages=716–723|issn=00468177|doi=10.1016/j.humpath.2009.10.016}}</ref>
===Endodermal sinus tumor===
===Endodermal sinus tumor===
*The pure form of these tumors are the third most common ovarian tumors.<ref name="Tewari2000">{{cite journal|last1=Tewari|first1=K|title=Malignant germ cell tumors of the ovary|journal=Obstetrics & Gynecology|volume=95|issue=1|year=2000|pages=128–133|issn=00297844|doi=10.1016/S0029-7844(99)00470-6}}</ref>
*The pure form of these [[tumors]] are the third most common [[ovarian]] [[tumors]].<ref name="Tewari2000">{{cite journal|last1=Tewari|first1=K|title=Malignant germ cell tumors of the ovary|journal=Obstetrics & Gynecology|volume=95|issue=1|year=2000|pages=128–133|issn=00297844|doi=10.1016/S0029-7844(99)00470-6}}</ref>
===Non-gestational choriocarcinoma===
===Non-gestational choriocarcinoma===
* These tumors comprised less than 1% of malignant ovarian germ cell tumors.<ref name="JiaoXiang2010">{{cite journal|last1=Jiao|first1=Lan-zhou|last2=Xiang|first2=Yang|last3=Feng|first3=Feng-zhi|last4=Wan|first4=Xi-run|last5=Zhao|first5=Jun|last6=Cui|first6=Quan-cai|last7=Yang|first7=Xiu-yu|title=Clinical Analysis of 21 Cases of Nongestational Ovarian Choriocarcinoma|journal=International Journal of Gynecological Cancer|volume=20|issue=2|year=2010|pages=299–302|issn=1048-891X|doi=10.1111/IGC.0b013e3181cc2526}}</ref>
* These [[Tumor|tumors]] comprised less than 1% of [[malignant]] [[ovarian]] [[germ cell]] [[tumors]].<ref name="JiaoXiang2010">{{cite journal|last1=Jiao|first1=Lan-zhou|last2=Xiang|first2=Yang|last3=Feng|first3=Feng-zhi|last4=Wan|first4=Xi-run|last5=Zhao|first5=Jun|last6=Cui|first6=Quan-cai|last7=Yang|first7=Xiu-yu|title=Clinical Analysis of 21 Cases of Nongestational Ovarian Choriocarcinoma|journal=International Journal of Gynecological Cancer|volume=20|issue=2|year=2010|pages=299–302|issn=1048-891X|doi=10.1111/IGC.0b013e3181cc2526}}</ref>
===Age===
===Age===
===Mature teratoma===
===Mature teratoma===
Line 43: Line 43:
===Dysgerminoma===
===Dysgerminoma===
*Dysgerminoma commonly affects individuals younger than 30 years of age in 85% of cases.<ref name="VicusBeiner2010">{{cite journal|last1=Vicus|first1=Danielle|last2=Beiner|first2=Mario E.|last3=Klachook|first3=Shany|last4=Le|first4=Lisa W.|last5=Laframboise|first5=Stephane|last6=Mackay|first6=Helen|title=Pure dysgerminoma of the ovary 35 years on: A single institutional experience|journal=Gynecologic Oncology|volume=117|issue=1|year=2010|pages=23–26|issn=00908258|doi=10.1016/j.ygyno.2009.12.024}}</ref>
*Dysgerminoma commonly affects individuals younger than 30 years of age in 85% of cases.<ref name="VicusBeiner2010">{{cite journal|last1=Vicus|first1=Danielle|last2=Beiner|first2=Mario E.|last3=Klachook|first3=Shany|last4=Le|first4=Lisa W.|last5=Laframboise|first5=Stephane|last6=Mackay|first6=Helen|title=Pure dysgerminoma of the ovary 35 years on: A single institutional experience|journal=Gynecologic Oncology|volume=117|issue=1|year=2010|pages=23–26|issn=00908258|doi=10.1016/j.ygyno.2009.12.024}}</ref>
*The median age at the time of diagnosis is approximately 19 to 23 years, although it may happen at any age.<ref name="pmid22407668">{{cite journal |vauthors=A L Husaini H, Soudy H, El Din Darwish A, Ahmed M, Eltigani A, A L Mubarak M, Sabaa AA, Edesa W, A L-Tweigeri T, Al-Badawi IA |title=Pure dysgerminoma of the ovary: a single institutional experience of 65 patients |journal=Med. Oncol. |volume=29 |issue=4 |pages=2944–8 |date=December 2012 |pmid=22407668 |doi=10.1007/s12032-012-0194-z |url=}}</ref>
*The median age at the time of [[diagnosis]] is approximately 19 to 23 years, although it may happen at any age.<ref name="pmid22407668">{{cite journal |vauthors=A L Husaini H, Soudy H, El Din Darwish A, Ahmed M, Eltigani A, A L Mubarak M, Sabaa AA, Edesa W, A L-Tweigeri T, Al-Badawi IA |title=Pure dysgerminoma of the ovary: a single institutional experience of 65 patients |journal=Med. Oncol. |volume=29 |issue=4 |pages=2944–8 |date=December 2012 |pmid=22407668 |doi=10.1007/s12032-012-0194-z |url=}}</ref>
*The tumor is uncommon prepubertal or postmenopausal.  
*The tumor is uncommon prepubertal or [[postmenopausal]].  
*[Chronic disease name] is usually first diagnosed among [age group].
*[Chronic disease name] is usually first diagnosed among [age group].
*[Acute disease name] commonly affects [age group].
*[Acute disease name] commonly affects [age group].
Line 52: Line 52:
*They affect primarily children and young adults.<ref name="ChenRuiz2003">{{cite journal|last1=Chen|first1=Vivien W.|last2=Ruiz|first2=Bernardo|last3=Killeen|first3=Jeffrey L.|last4=Cot�|first4=Timothy R.|last5=Wu|first5=Xiao Cheng|last6=Correa|first6=Catherine N.|last7=Howe|first7=Holly L.|title=Pathology and classification of ovarian tumors|journal=Cancer|volume=97|issue=S10|year=2003|pages=2631–2642|issn=0008-543X|doi=10.1002/cncr.11345}}</ref>
*They affect primarily children and young adults.<ref name="ChenRuiz2003">{{cite journal|last1=Chen|first1=Vivien W.|last2=Ruiz|first2=Bernardo|last3=Killeen|first3=Jeffrey L.|last4=Cot�|first4=Timothy R.|last5=Wu|first5=Xiao Cheng|last6=Correa|first6=Catherine N.|last7=Howe|first7=Holly L.|title=Pathology and classification of ovarian tumors|journal=Cancer|volume=97|issue=S10|year=2003|pages=2631–2642|issn=0008-543X|doi=10.1002/cncr.11345}}</ref>
===Choriocarcinoma===
===Choriocarcinoma===
*They can be primary (non-gestational) or secondary to pregnancy (gestational).<ref name="ChenRuiz2003">{{cite journal|last1=Chen|first1=Vivien W.|last2=Ruiz|first2=Bernardo|last3=Killeen|first3=Jeffrey L.|last4=Cot�|first4=Timothy R.|last5=Wu|first5=Xiao Cheng|last6=Correa|first6=Catherine N.|last7=Howe|first7=Holly L.|title=Pathology and classification of ovarian tumors|journal=Cancer|volume=97|issue=S10|year=2003|pages=2631–2642|issn=0008-543X|doi=10.1002/cncr.11345}}</ref>
*They can be primary (non-[[Gestation period|gestational]]) or secondary to [[pregnancy]] ([[Gestational age|gestational]]).<ref name="ChenRuiz2003">{{cite journal|last1=Chen|first1=Vivien W.|last2=Ruiz|first2=Bernardo|last3=Killeen|first3=Jeffrey L.|last4=Cot�|first4=Timothy R.|last5=Wu|first5=Xiao Cheng|last6=Correa|first6=Catherine N.|last7=Howe|first7=Holly L.|title=Pathology and classification of ovarian tumors|journal=Cancer|volume=97|issue=S10|year=2003|pages=2631–2642|issn=0008-543X|doi=10.1002/cncr.11345}}</ref>
*Primary type affects children and young adults.
*Primary type affects children and young adults.
===Race===
===Race===
*There is no racial predilection to ovarian germ cell tumors.
*There is no [[racial]] predilection to [[ovarian]] [[germ cell]] [[tumors]].
===Gender===
===Gender===
*Females are more commonly affected by germ cell tumors than males.<ref name="SmithBerwick2006">{{cite journal|last1=Smith|first1=Harriet O.|last2=Berwick|first2=Marianne|last3=Verschraegen|first3=Claire F.|last4=Wiggins|first4=Charles|last5=Lansing|first5=Letitia|last6=Muller|first6=Carolyn Y.|last7=Qualls|first7=Clifford R.|title=Incidence and Survival Rates for Female Malignant Germ Cell Tumors|journal=Obstetrics & Gynecology|volume=107|issue=5|year=2006|pages=1075–1085|issn=0029-7844|doi=10.1097/01.AOG.0000216004.22588.ce}}</ref>
*Females are more commonly affected by [[germ cell]] [[tumors]] than males.<ref name="SmithBerwick2006">{{cite journal|last1=Smith|first1=Harriet O.|last2=Berwick|first2=Marianne|last3=Verschraegen|first3=Claire F.|last4=Wiggins|first4=Charles|last5=Lansing|first5=Letitia|last6=Muller|first6=Carolyn Y.|last7=Qualls|first7=Clifford R.|title=Incidence and Survival Rates for Female Malignant Germ Cell Tumors|journal=Obstetrics & Gynecology|volume=107|issue=5|year=2006|pages=1075–1085|issn=0029-7844|doi=10.1097/01.AOG.0000216004.22588.ce}}</ref>
===Region===
===Region===
*Germ cell tumors of the ovary account for a greater proportion of ovarian tumors in the Asia and Africa.<ref name="SmithBerwick2006">{{cite journal|last1=Smith|first1=Harriet O.|last2=Berwick|first2=Marianne|last3=Verschraegen|first3=Claire F.|last4=Wiggins|first4=Charles|last5=Lansing|first5=Letitia|last6=Muller|first6=Carolyn Y.|last7=Qualls|first7=Clifford R.|title=Incidence and Survival Rates for Female Malignant Germ Cell Tumors|journal=Obstetrics & Gynecology|volume=107|issue=5|year=2006|pages=1075–1085|issn=0029-7844|doi=10.1097/01.AOG.0000216004.22588.ce}}</ref>
*[[Germ cell]] [[tumors]] of the [[ovary]] account for a greater proportion of [[ovarian]] [[tumors]] in the Asia and Africa.<ref name="SmithBerwick2006">{{cite journal|last1=Smith|first1=Harriet O.|last2=Berwick|first2=Marianne|last3=Verschraegen|first3=Claire F.|last4=Wiggins|first4=Charles|last5=Lansing|first5=Letitia|last6=Muller|first6=Carolyn Y.|last7=Qualls|first7=Clifford R.|title=Incidence and Survival Rates for Female Malignant Germ Cell Tumors|journal=Obstetrics & Gynecology|volume=107|issue=5|year=2006|pages=1075–1085|issn=0029-7844|doi=10.1097/01.AOG.0000216004.22588.ce}}</ref>
*Dysgerminomas has been reported to have high prevalences in India and Japan.<ref name="ChenRuiz2003">{{cite journal|last1=Chen|first1=Vivien W.|last2=Ruiz|first2=Bernardo|last3=Killeen|first3=Jeffrey L.|last4=Cot�|first4=Timothy R.|last5=Wu|first5=Xiao Cheng|last6=Correa|first6=Catherine N.|last7=Howe|first7=Holly L.|title=Pathology and classification of ovarian tumors|journal=Cancer|volume=97|issue=S10|year=2003|pages=2631–2642|issn=0008-543X|doi=10.1002/cncr.11345}}</ref>
*Dysgerminomas has been reported to have high [[prevalence]] in India and Japan.<ref name="ChenRuiz2003">{{cite journal|last1=Chen|first1=Vivien W.|last2=Ruiz|first2=Bernardo|last3=Killeen|first3=Jeffrey L.|last4=Cot�|first4=Timothy R.|last5=Wu|first5=Xiao Cheng|last6=Correa|first6=Catherine N.|last7=Howe|first7=Holly L.|title=Pathology and classification of ovarian tumors|journal=Cancer|volume=97|issue=S10|year=2003|pages=2631–2642|issn=0008-543X|doi=10.1002/cncr.11345}}</ref>


===Developed Countries===
===Developed Countries===

Revision as of 21:09, 13 March 2019

Ovarian germ cell tumor Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Epidemiology and Demographics

Risk Factors

Screening

Differentiating Ovarian germ cell tumor from other Diseases

Natural History, Complications and Prognosis

Diagnosis

Staging

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Surgery

Chemotherapy

Radiotherapy

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Ovarian germ cell tumor epidemiology and demographics On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Ovarian germ cell tumor epidemiology and demographics

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Ovarian germ cell tumor epidemiology and demographics

CDC on Ovarian germ cell tumor epidemiology and demographics

Ovarian germ cell tumor epidemiology and demographics in the news

Blogs on Ovarian germ cell tumor epidemiology and demographics

Directions to Hospitals Treating Ovarian germ cell tumor

Risk calculators and risk factors for Ovarian germ cell tumor epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Overview

Epidemiology and Demographics

Incidence

Mature teratoma

Dysgerminoma

Yolk sac tumor

Embryonal carcinoma

Choriocarcinom

Prevalence

Mature teratoma

Dysgerminoma

Mixed germ cell tumor

Embryonal carcinoma

Endodermal sinus tumor

Non-gestational choriocarcinoma

Age

Mature teratoma

  • Patients of all age groups may develop mature teratoma. However, they tend to present between 20 to 30 years of age at a greater extent.[10]
  • The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.

Immature teratoma

  • Immature teratoma tends to affect younger patient than mature teratomas (usually the first 2 decades of life).[11]

Dysgerminoma

  • Dysgerminoma commonly affects individuals younger than 30 years of age in 85% of cases.[6]
  • The median age at the time of diagnosis is approximately 19 to 23 years, although it may happen at any age.[12]
  • The tumor is uncommon prepubertal or postmenopausal.
  • [Chronic disease name] is usually first diagnosed among [age group].
  • [Acute disease name] commonly affects [age group].

Yolk sac tumor

  • They are most common in women in the second and third decades of life and rarely happens after the age 40.[13]

Embryonal carcinoma

  • They affect primarily children and young adults.[14]

Choriocarcinoma

Race

Gender

Region

Developed Countries

Developing Countries

References

  1. ↑ Pectasides, D.; Pectasides, E.; Kassanos, D. (2008). "Germ cell tumors of the ovary". Cancer Treatment Reviews. 34 (5): 427–441. doi:10.1016/j.ctrv.2008.02.002. ISSN 0305-7372.
  2. ↑ Westhoff C, Pike M, Vessey M (July 1988). "Benign ovarian teratomas: a population-based case-control study". Br. J. Cancer. 58 (1): 93–8. PMC 2246492. PMID 3166898.
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Smith, Harriet O.; Berwick, Marianne; Verschraegen, Claire F.; Wiggins, Charles; Lansing, Letitia; Muller, Carolyn Y.; Qualls, Clifford R. (2006). "Incidence and Survival Rates for Female Malignant Germ Cell Tumors". Obstetrics & Gynecology. 107 (5): 1075–1085. doi:10.1097/01.AOG.0000216004.22588.ce. ISSN 0029-7844.
  4. ↑ Shaaban, Akram M.; Rezvani, Maryam; Elsayes, Khaled M.; Baskin, Henry; Mourad, Amr; Foster, Bryan R.; Jarboe, Elke A.; Menias, Christine O. (2014). "Ovarian Malignant Germ Cell Tumors: Cellular Classification and Clinical and Imaging Features". RadioGraphics. 34 (3): 777–801. doi:10.1148/rg.343130067. ISSN 0271-5333.
  5. ↑ 5.0 5.1 Ulbright, Thomas M (2005). "Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues". Modern Pathology. 18: S61–S79. doi:10.1038/modpathol.3800310. ISSN 0893-3952.
  6. ↑ 6.0 6.1 Vicus, Danielle; Beiner, Mario E.; Klachook, Shany; Le, Lisa W.; Laframboise, Stephane; Mackay, Helen (2010). "Pure dysgerminoma of the ovary 35 years on: A single institutional experience". Gynecologic Oncology. 117 (1): 23–26. doi:10.1016/j.ygyno.2009.12.024. ISSN 0090-8258.
  7. ↑ 7.0 7.1 Tewari, K (2000). "Malignant germ cell tumors of the ovary". Obstetrics & Gynecology. 95 (1): 128–133. doi:10.1016/S0029-7844(99)00470-6. ISSN 0029-7844.
  8. ↑ Cheng, Liang; Zhang, Shaobo; Talerman, Aleksander; Roth, Lawrence M. (2010). "Morphologic, immunohistochemical, and fluorescence in situ hybridization study of ovarian embryonal carcinoma with comparison to solid variant of yolk sac tumor and immature teratoma". Human Pathology. 41 (5): 716–723. doi:10.1016/j.humpath.2009.10.016. ISSN 0046-8177.
  9. ↑ Jiao, Lan-zhou; Xiang, Yang; Feng, Feng-zhi; Wan, Xi-run; Zhao, Jun; Cui, Quan-cai; Yang, Xiu-yu (2010). "Clinical Analysis of 21 Cases of Nongestational Ovarian Choriocarcinoma". International Journal of Gynecological Cancer. 20 (2): 299–302. doi:10.1111/IGC.0b013e3181cc2526. ISSN 1048-891X.
  10. ↑ Yayla Abide, Çiğdem; Bostancı Ergen, Evrim (2018). "Retrospective analysis of mature cystic teratomas in a single center and review of the literature". Journal of Turkish Society of Obstetric and Gynecology. 15 (2): 95–98. doi:10.4274/tjod.86244. ISSN 1307-699X.
  11. ↑ Outwater, Eric K.; Siegelman, Evan S.; Hunt, Jennifer L. (2001). "Ovarian Teratomas: Tumor Types and Imaging Characteristics". RadioGraphics. 21 (2): 475–490. doi:10.1148/radiographics.21.2.g01mr09475. ISSN 0271-5333.
  12. ↑ A L Husaini H, Soudy H, El Din Darwish A, Ahmed M, Eltigani A, A L Mubarak M, Sabaa AA, Edesa W, A L-Tweigeri T, Al-Badawi IA (December 2012). "Pure dysgerminoma of the ovary: a single institutional experience of 65 patients". Med. Oncol. 29 (4): 2944–8. doi:10.1007/s12032-012-0194-z. PMID 22407668. Vancouver style error: missing comma (help)
  13. ↑ Kurman RJ, Norris HJ (December 1976). "Endodermal sinus tumor of the ovary: a clinical and pathologic analysis of 71 cases". Cancer. 38 (6): 2404–19. PMID 63318.
  14. ↑ 14.0 14.1 14.2 Chen, Vivien W.; Ruiz, Bernardo; Killeen, Jeffrey L.; Cot�, Timothy R.; Wu, Xiao Cheng; Correa, Catherine N.; Howe, Holly L. (2003). "Pathology and classification of ovarian tumors". Cancer. 97 (S10): 2631–2642. doi:10.1002/cncr.11345. ISSN 0008-543X. replacement character in |last4= at position 4 (help)

Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Ovarian_germ_cell_tumor_epidemiology_and_demographics&oldid=1558009"