Ovarian germ cell tumor diagnostic study of choice: Difference between revisions

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Latest revision as of 13:51, 22 April 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2] Monalisa Dmello, M.B,B.S., M.D. [3]

Overview

Histology of the excised tumor after surgery is the gold standard test for the diagnosis of ovarian germ cell tumors. Surgery must be performed when the patient presents with an adnexal mass in the abdominal/pelvic exam and elevated serum concentration of associated tumor markers. Mature teratoma may be diagnosed using ultrasonographic imaging. However, the tumor should be removed surgically.

Diagnostic Study of Choice

Histology of the excised tumor after surgery is the gold standard test for the diagnosis of ovarian germ cell tumors.^[1]^[2]

Surgery must be performed when:
- The patient presents with an adnexal mass in the abdominal/pelvic exam, and elevated serum concentration of hCG, LDH, AFP, and other associated tumor markers.
- Mature teratoma may be diagnosed using ultrasonographic imaging. However, the tumor should be removed surgically.

Malignant germ cell tumor

Prior surgery

Initial surgery

Complete staging

Incomplete staging

Fertility sparing prefered

Fertility sparing not prefered

Treatment based
on
the staging

Imaging:
Chest/
abdomen/
pelvis CT with contrast

Fertility sparing surgery
and
complete staging

Surgery to stage

Treatment based on the staging and pathology of tumor

Yolk sac tumor
grade2-3 immature teratoma,
non-gestational choriocarcinoma
or mixed histology

Dysgerminoma
or
grade 1 immature teratoma

Imaging and tumor markers
are
positive

Negative imaging
and
positive tumor markers

Negative imaging
and
negative or positive tumor markers

Decide according to fertility sparing preference
and/or pathologic finding
for surgery and
further adjuant therapy

Observe

Imaging and tumor markers
are
positive

Negative imaging
and
negative and positive tumor markers

Decide
according to
fertility sparing preference
for surgery and further chemotherapy

References

↑ Pectasides, D.; Pectasides, E.; Kassanos, D. (2008). "Germ cell tumors of the ovary". Cancer Treatment Reviews. 34 (5): 427–441. doi:10.1016/j.ctrv.2008.02.002. ISSN 0305-7372.
↑ Low, Jeffrey J.H.; Ilancheran, Arunachalam; Ng, Joseph S. (2012). "Malignant ovarian germ-cell tumours". Best Practice & Research Clinical Obstetrics & Gynaecology. 26 (3): 347–355. doi:10.1016/j.bpobgyn.2012.01.002. ISSN 1521-6934.

Template:WH Template:WS

Template:WikiDoc Sources

[PectasidesPectasides2008-1] Pectasides, D.; Pectasides, E.; Kassanos, D. (2008). "Germ cell tumors of the ovary". Cancer Treatment Reviews. 34 (5): 427–441. doi:10.1016/j.ctrv.2008.02.002. ISSN 0305-7372.

[LowIlancheran2012-2] Low, Jeffrey J.H.; Ilancheran, Arunachalam; Ng, Joseph S. (2012). "Malignant ovarian germ-cell tumours". Best Practice & Research Clinical Obstetrics & Gynaecology. 26 (3): 347–355. doi:10.1016/j.bpobgyn.2012.01.002. ISSN 1521-6934.

[1]

[2]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Ovarian germ cell tumor}}
-{{CMG}}; {{AE}}
+{{CMG}}; {{AE}} {{Sahar}} {{MD}}
 == Overview ==
-Histology of the excised tumor after surgery is the gold standard test for the diagnosis of ovarian germ cell tumors. Surgery must be performed when the patient presents with an adnexal mass in the abdominal/pelvic exam and elevated serum concentration of associated tumor markers. Mature teratoma may be diagnosed using ultrasonographic imaging. However, the tumor should be removed surgically.
+[[Histology]] of the excised [[tumor]] after [[surgery]] is the [[Gold standard (test)|gold standard]] test for the [[diagnosis]] of [[ovarian]] [[germ cell]] [[Tumor|tumors]]. [[Surgery]] must be performed when the patient presents with an [[adnexal]] [[mass]] in the [[abdominal]]/[[pelvic]] [[Physical examination|exam]] and elevated serum concentration of associated [[tumor markers]]. [[Mature cystic teratoma|Mature teratoma]] may be [[Diagnosis|diagnosed]] using [[Ultrasound|ultrasonographic imaging]]. However, the [[tumor]] should be removed [[Surgery|surgically]].
 == Diagnostic Study of Choice ==
-Histology of the excised tumor after surgery is the gold standard test for the diagnosis of ovarian germ cell tumors.<ref name="PectasidesPectasides2008">{{cite journal|last1=Pectasides|first1=D.|last2=Pectasides|first2=E.|last3=Kassanos|first3=D.|title=Germ cell tumors of the ovary|journal=Cancer Treatment Reviews|volume=34|issue=5|year=2008|pages=427–441|issn=03057372|doi=10.1016/j.ctrv.2008.02.002}}</ref><ref name="LowIlancheran2012">{{cite journal|last1=Low|first1=Jeffrey J.H.|last2=Ilancheran|first2=Arunachalam|last3=Ng|first3=Joseph S.|title=Malignant ovarian germ-cell tumours|journal=Best Practice & Research Clinical Obstetrics & Gynaecology|volume=26|issue=3|year=2012|pages=347–355|issn=15216934|doi=10.1016/j.bpobgyn.2012.01.002}}</ref>
+[[Histology]] of the excised [[tumor]] after [[surgery]] is the [[Gold standard (test)|gold standard]] test for the [[diagnosis]] of [[ovarian]] [[germ cell]] [[tumors]].<ref name="PectasidesPectasides2008">{{cite journal|last1=Pectasides|first1=D.|last2=Pectasides|first2=E.|last3=Kassanos|first3=D.|title=Germ cell tumors of the ovary|journal=Cancer Treatment Reviews|volume=34|issue=5|year=2008|pages=427–441|issn=03057372|doi=10.1016/j.ctrv.2008.02.002}}</ref><ref name="LowIlancheran2012">{{cite journal|last1=Low|first1=Jeffrey J.H.|last2=Ilancheran|first2=Arunachalam|last3=Ng|first3=Joseph S.|title=Malignant ovarian germ-cell tumours|journal=Best Practice & Research Clinical Obstetrics & Gynaecology|volume=26|issue=3|year=2012|pages=347–355|issn=15216934|doi=10.1016/j.bpobgyn.2012.01.002}}</ref>
-* Surgery must be performed when:
+* [[Surgery]] must be performed when:
-** The patient presents with an adnexal mass in the abdominal/pelvic exam, and elevated serum concentration of hCG, LDH, AFP, and other associated tumor markers.
+** The patient presents with an [[adnexal]] [[mass]] in the [[abdominal]]/[[pelvic]] exam, and elevated serum concentration of [[Human chorionic gonadotropin|hCG]], [[Lactate dehydrogenase|LDH]], [[AFP]], and other associated [[tumor markers]].
-** Mature teratoma may be diagnosed using ultrasonographic imaging. However, the tumor should be removed surgically.
+** [[Mature cystic teratoma|Mature teratoma]] may be [[Diagnose|diagnosed]] using [[Ultrasound imaging|ultrasonographic imaging]]. However, the [[tumor]] should be removed [[Surgery|surgically]].
 {{familytree/start |summary=PE diagnosis Algorithm.}}
-{{familytree | | | | | | | | | | A02 | | | | | |A02=Malignant germ cell tumor}}
+{{familytree | | | | | | | | | | A02 | | | | | |A02=[[Malignant]] [[germ cell]] [[tumor]]}}
 {{familytree | | | |,|-|-|-|-|-|-|^|-|-|-|-|-|-|-|.| | | | | | }}
-{{familytree | | | C01 | | | | | | | | | | | | | C02 | | |C01=Prior surgery|C02=Initial surgery}}
+{{familytree | | | C01 | | | | | | | | | | | | | C02 | | |C01=Prior [[surgery]]|C02=Initial [[surgery]]}}
 {{familytree | |,|-|^|-|.| | | | | | | | | | |,|-|^|-|.| | }}
-{{familytree | D01 | | D02 | | | | | | | | | D03 | | D04 |D01=Complete staging|D02=Incomplete staging|D03=Fertility sparing prefered|D04=Fertility sparing not prefered}}
+{{familytree | D01 | | D02 | | | | | | | | | D03 | | D04 |D01=Complete staging|D02=Incomplete staging|D03=[[Fertility]] sparing prefered|D04=[[Fertility]] sparing not prefered}}
 {{familytree | |!| | | |!| | | | | | | | | | |!| | | |!| | }}
-{{familytree | E01 | | E02 | | | | | | | | | E03 | | E04 |E01=Treatment based<br>on<br>the staging|E02=Imaging:<br>Chest/<br>abdomen/<br>pelvis CT with contrast|E03=Fertility sparing surgery<br>and<br>complete staging|E04=Surgery to stage}}
+{{familytree | E01 | | E02 | | | | | | | | | E03 | | E04 |E01=Treatment based<br>on<br>the staging|E02=[[Imaging]]:<br>[[Chest]]/<br>[[abdomen]]/<br>[[pelvis]] [[CT]] with [[contrast]]|E03=[[Fertility]] sparing [[surgery]]<br>and<br>complete staging|E04=[[Surgery]] to stage}}
 {{familytree | | | | | |!| | | | | | | | | | |!| | | |!| | | | }}
-{{familytree | | | | | |!| | | | | | | | | | |`| F02 |'| | | |F02=Treatment based on the staging and pathology of tumor}}
+{{familytree | | | | | |!| | | | | | | | | | |`| F02 |'| | | |F02=Treatment based on the staging and [[pathology]] of [[tumor]]}}
 {{familytree | | | |,|-|^|-|-|-|-|-|-|-|.| | | | | | | }}
-{{familytree | | | G01 | | | | | | | | G02 | | | | | | | | | | | | | | |G01=Yolk sac tumor<br>grade2-3 immature teratoma,<br>non-gestational choriocarcinoma<br>or mixed histology|G02=Dysgerminoma<br>or<br>grade 1 immature teratoma|L03=Dysgerminoma or grade 1 immature teratoma}}
+{{familytree | | | G01 | | | | | | | | G02 | | | | | | | | | | | | | | |G01=[[Yolk sac tumor]]<br>grade2-3 immature [[teratoma]],<br>non-gestational [[choriocarcinoma]]<br>or mixed [[histology]]|G02=[[Dysgerminoma]]<br>or<br>grade 1 immature [[teratoma]]|L03=[[Dysgerminoma]] or grade 1 immature [[teratoma]]}}
 {{familytree | | | |!| | | | | | | | | |!| | | | | | | | | | | | }}
 {{familytree | | | |!| | | | | |,|-|-|-|+|-|-|-|.|}}
-{{familytree | | | |!| | | | | I02 | | I03 | | I04 | |I02=Imaging and tumor markers<br>are<br>positive|I03=Negative imaging<br>and<br>positive tumor markers|I04=Negative imaging<br>and<br>negative or positive tumor markers}}
+{{familytree | | | |!| | | | | I02 | | I03 | | I04 | |I02=[[Imaging]] and [[tumor markers]]<br>are<br>positive|I03=Negative [[imaging]]<br>and<br>positive [[tumor markers]]|I04=Negative [[imaging]]<br>and<br>negative or positive [[tumor markers]]}}
 {{familytree | | | |!| | | | | |!| | | |!| | | |!| | | |}}
-{{familytree | |,|-|^|-|.| | | K03 | | K04 | | K05 | | |K03=Decide according to fertility sparing preference<br>and/or pathologic finding<br>for surgery and<br>further adjuant therapy|K04=Observe|K05=Observe|}}
+{{familytree | |,|-|^|-|.| | | K03 | | K04 | | K05 | | |K03=Decide according to [[fertility]] sparing preference<br>and/or [[pathologic]] finding<br>for [[surgery]] and<br>further [[adjuant therapy]]|K04=Observe|K05=Observe|}}
-{{familytree | J01 | | J02 | | | | | | | | | | | | | | | | | | |J01=Imaging and tumor markers<br>are<br>positive|J02=Negative imaging<br>and<br>negative and positive tumor markers}}
+{{familytree | J01 | | J02 | | | | | | | | | | | | | | | | | | |J01=[[Imaging]] and [[tumor markers]]<br>are<br>positive|J02=Negative [[imaging]]<br>and<br>negative and positive [[tumor markers]]}}
 {{familytree | |!| | | | | | | | | | | | | | | | | | | | | |}}
-{{familytree | K01 | | | | | | | | | | | | | | | | | | | |K01=Decide<br>according to<br>fertility sparing preference<br>for surgery and further chemotherapy|}}
+{{familytree | K01 | | | | | | | | | | | | | | | | | | | |K01=Decide<br>according to<br>[[fertility]] sparing preference<br>for [[surgery]] and further [[chemotherapy]]|}}
 {{familytree | | | | | | | | | | | | | | | | | | | | | | | |}}
 {{familytree | | | | | | | | | | | | | | | | | | | | | | | |}}
 {{familytree/end}}
-=== Name of Diagnostic Criteria ===
-'''It is recommended that you include the criteria in a table. Make sure you always cite the source of the content and whether the table has been adapted from another source.'''
-[Disease name] is primarily diagnosed based on clinical presentation. There are no established criteria for the diagnosis of [disease name].
-OR
-There is no single diagnostic study of choice for [disease name], though [disease name] may be diagnosed based on [name of criteria] established by [...].
-OR
-The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].
-OR
-The diagnosis of [disease name] is based on the [criteria name] criteria, which includes [criterion 1], [criterion 2], and [criterion 3].
-OR
-[Disease name] may be diagnosed at any time if one or more of the following criteria are met:
-* Criteria 1
-* Criteria 2
-* Criteria 3
-OR
-'''IF there are clear, established diagnostic criteria'''
-The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].
-OR
-The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].
-OR
-The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].
-OR
-'''IF there are no established diagnostic criteria'''
-There are no established criteria for the diagnosis of [disease name].
 ==References==
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 {{WH}}
 {{WS}}
+[[Category:Disease]]
+[[Category:Types of cancer]]
+[[Category:Gynecology]]
+{{WikiDoc Help Menu}}
+{{WikiDoc Sources}}
+ [[Category:Up-To-Date]]
+[[Category:Oncology]]
+[[Category:Medicine]]
+[[Category:Gynecology]]
+[[Category:Surgery]]

Ovarian germ cell tumor diagnostic study of choice: Difference between revisions

Latest revision as of 13:51, 22 April 2019

Overview

Diagnostic Study of Choice

References

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