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==Overview==
==Overview==


'''Osteoma''' (also known as ''Osteomata'') is a  slow growing benign tumor of bone, occurring most commonly in the [[craniofacial]] skeletal structures, primarily in the nasal and [[paranasal]] (75-90%) cavities.<ref name="pmid25767729">{{cite journal |vauthors=Abdel Tawab HM, Kumar V R, Tabook SM |title=Osteoma presenting as a painless solitary mastoid swelling |journal=Case Rep Otolaryngol |volume=2015 |issue= |pages=590783 |year=2015 |pmid=25767729 |pmc=4341844 |doi=10.1155/2015/590783 |url=}}</ref> Osteoma arises from bone overgrowth, which is normally composed of [[connective tissue]]. Osteomas are slow growing tumors composed of compact or mature [[trabecular bone]] limited to craniofacial bones. Osteoma may be incidentally identified as a mass in the [[skull]], [[mandible]], or as the underlying cause of [[sinusitis]] or [[mucocele]] formation within the [[paranasal sinuses]].<ref name="pmid8272884">{{cite journal |vauthors=Greenspan A |title=Benign bone-forming lesions: osteoma, osteoid osteoma, and osteoblastoma. Clinical, imaging, pathologic, and differential considerations |journal=Skeletal Radiol. |volume=22 |issue=7 |pages=485–500 |year=1993 |pmid=8272884 |doi= |url=}}</ref> When they are multiple, Gardner syndrome should be considered.<ref name="pmid8272884">{{cite journal |vauthors=Greenspan A |title=Benign bone-forming lesions: osteoma, osteoid osteoma, and osteoblastoma. Clinical, imaging, pathologic, and differential considerations |journal=Skeletal Radiol. |volume=22 |issue=7 |pages=485–500 |year=1993 |pmid=8272884 |doi= |url=}}</ref> Osteoma represents the most common benign neoplasm of the nose and paranasal sinuses. The causes remain uncertain, but commonly accepted theories propose embryologic, traumatic, or infectious causes. Osteomas are usually asymptomatic. Excision may be performed if osteoma is  responsible for symptoms.<ref name="pmid8272884">{{cite journal |vauthors=Greenspan A |title=Benign bone-forming lesions: osteoma, osteoid osteoma, and osteoblastoma. Clinical, imaging, pathologic, and differential considerations |journal=Skeletal Radiol. |volume=22 |issue=7 |pages=485–500 |year=1993 |pmid=8272884 |doi= |url=}}</ref>
'''Osteoma''' (also known as ''Osteomata'') is a  slow growing benign tumor of bone, occurring most commonly in the [[craniofacial]] skeletal structures, primarily in the nasal and [[paranasal]] (75-90%) cavities. Osteoma arises from bone overgrowth, which is normally composed of [[connective tissue]]. Osteomas are slow growing tumors composed of compact or mature [[trabecular bone]] limited to craniofacial bones. Osteoma may be incidentally identified as a mass in the [[skull]], [[mandible]], or as the underlying cause of [[sinusitis]] or [[mucocele]] formation within the [[paranasal sinuses]]. When they are multiple, Gardner syndrome should be considered. Osteoma represents the most common benign neoplasm of the nose and paranasal sinuses. The causes remain uncertain, but commonly accepted theories propose embryologic, traumatic, or infectious causes. Osteomas are usually asymptomatic. Excision may be performed if osteoma is  responsible for symptoms.


==Historical Perspective==
==Historical Perspective==
In 1898, Paul Schulze, was the first to describe a craniofacial skeletal osteoma.<ref name="paul"> Paul Schulze (1898) Osteoma internum sarcomatosum des oberkiefers. <''German''>. HOLLIS Catalog. Harvard Countway Library</ref>
In 1898, Paul Schulze, was the first to describe a craniofacial skeletal osteoma.


==Classification==
==Classification==
Osteoma may be classified into either sporadic or multiple forms. The different subtypes of osteoma include: ivory osteoma, mature osteoma, and mixed osteoma.<ref> Osteoma. Dr Ahmed Abd Rabou and A.Prof Frank Gaillard et al.http://radiopaedia.org/articles/osteoma Accessed on January 15,2016</ref>
Osteoma may be classified into either sporadic or multiple forms. The different subtypes of osteoma include: ivory osteoma, mature osteoma, and mixed osteoma.


==Pathophysiology==
==Pathophysiology==
Osteoma is a  slow growing benign tumor of bone, occurring most commonly in the [[craniofacial]] skeletal structures, primarily in the nasal and [[paranasal]] (75-90%) cavities.<ref name="pmid25767729">{{cite journal |vauthors=Abdel Tawab HM, Kumar V R, Tabook SM |title=Osteoma presenting as a painless solitary mastoid swelling |journal=Case Rep Otolaryngol |volume=2015 |issue= |pages=590783 |year=2015 |pmid=25767729 |pmc=4341844 |doi=10.1155/2015/590783 |url=}}</ref> Osteoma arises from bone overgrowth, which is normally composed of [[connective tissue]]. Osteomas are slow growing tumors composed of compact or mature [[trabecular bone]] limited to craniofacial bones. The most common gene affected in multiple osteoma is the [[APC]] gene.
Osteoma is a  slow growing benign tumor of bone, occurring most commonly in the [[craniofacial]] skeletal structures, primarily in the nasal and [[paranasal]] (75-90%) cavities. Osteoma arises from bone overgrowth, which is normally composed of [[connective tissue]]. Osteomas are slow growing tumors composed of compact or mature [[trabecular bone]] limited to craniofacial bones. The most common gene affected in multiple osteoma is the [[APC]] gene.


==Causes==
==Causes==
The cause of an osteoma has not been identified, but commonly accepted theories propose embryological, traumatic, or infective causes.<ref name="pmid25767729">{{cite journal |vauthors=Abdel Tawab HM, Kumar V R, Tabook SM |title=Osteoma presenting as a painless solitary mastoid swelling |journal=Case Rep Otolaryngol |volume=2015 |issue= |pages=590783 |year=2015 |pmid=25767729 |pmc=4341844 |doi=10.1155/2015/590783 |url=}}</ref>
The cause of an osteoma has not been identified, but commonly accepted theories propose embryological, traumatic, or infective causes.


==Differentiating Osteoma from other Diseases==
==Differentiating Osteoma from other Diseases==
Osteoma must be differentiated from other diseases that cause sinus or facial pain, headache, and changes to or loss of sense of smell, such as other osteogenic tumours, fibrous displasia, and chronic sinusitis.<ref name="pmid19780030">{{cite journal |vauthors=Erdogan N, Demir U, Songu M, Ozenler NK, Uluç E, Dirim B |title=A prospective study of paranasal sinus osteomas in 1,889 cases: changing patterns of localization |journal=Laryngoscope |volume=119 |issue=12 |pages=2355–9 |year=2009 |pmid=19780030 |doi=10.1002/lary.20646 |url=}}</ref>
Osteoma must be differentiated from other diseases that cause sinus or facial pain, headache, and changes to or loss of sense of smell, such as other osteogenic tumours, fibrous displasia, and chronic sinusitis.


==Epidemiology and Demographics==
==Epidemiology and Demographics==
Osteoma is the most common benign neoplasm of the nose and paranasal sinuses. The prevalence of osteoma is 3% in general population. It mainly affects adults and children. The mean age at diagnosis is 37 years. Men are more commonly affected than women, with a 3:2 ratio.<ref name="pmid19780030">{{cite journal |vauthors=Erdogan N, Demir U, Songu M, Ozenler NK, Uluç E, Dirim B |title=A prospective study of paranasal sinus osteomas in 1,889 cases: changing patterns of localization |journal=Laryngoscope |volume=119 |issue=12 |pages=2355–9 |year=2009 |pmid=19780030 |doi=10.1002/lary.20646 |url=}}</ref>
Osteoma is the most common benign neoplasm of the nose and paranasal sinuses. The prevalence of osteoma is 3% in general population. It mainly affects adults and children. The mean age at diagnosis is 37 years. Men are more commonly affected than women, with a 3:2 ratio.


==Risk Factors==
==Risk Factors==
The risk factors of osteoma remain unknown.<ref name="pmid25767729">{{cite journal |vauthors=Abdel Tawab HM, Kumar V R, Tabook SM |title=Osteoma presenting as a painless solitary mastoid swelling |journal=Case Rep Otolaryngol |volume=2015 |issue= |pages=590783 |year=2015 |pmid=25767729 |pmc=4341844 |doi=10.1155/2015/590783 |url=}}</ref>
The risk factors of osteoma remain unknown.


==Screening==
==Screening==
Screening for multiple osteomas is recommended among patients with [[family history]] or/and a confirmed diagnosis of Gardner syndrome. [[Thyroid]] exam and annual ultrasound, should be performed starting at age 10 to 12 years.<ref name="pmid24093640">{{cite journal |vauthors=Septer S, Slowik V, Morgan R, Dai H, Attard T |title=Thyroid cancer complicating familial adenomatous polyposis: mutation spectrum of at-risk individuals |journal=Hered Cancer Clin Pract |volume=11 |issue=1 |pages=13 |year=2013 |pmid=24093640 |pmc=3854022 |doi=10.1186/1897-4287-11-13 |url=}}</ref>
Screening for multiple osteomas is recommended among patients with [[family history]] or/and a confirmed diagnosis of Gardner syndrome. [[Thyroid]] exam and annual ultrasound, should be performed starting at age 10 to 12 years.


==Natural History, Complications and Prognosis==
==Natural History, Complications and Prognosis==
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===Staging===
===Staging===


There is no established system for the staging of osteoma.<ref name="pmid8272884">{{cite journal |vauthors=Greenspan A |title=Benign bone-forming lesions: osteoma, osteoid osteoma, and osteoblastoma. Clinical, imaging, pathologic, and differential considerations |journal=Skeletal Radiol. |volume=22 |issue=7 |pages=485–500 |year=1993 |pmid=8272884 |doi= |url=}}</ref>
There is no established system for the staging of osteoma.


===History and Symptoms===
===History and Symptoms===
The hallmark of osteoma is facial pain and [[headache]]. A positive history of [[Gardner syndrome]] is suggestive of multiple osteomas. Symptoms related with osteoma will vary depending on the size and location of the tumor. Small osteomas are asymptomatic and usually incidental findings. Conversely, common symptoms of large paranasal sinus osteomas may be [[headache]], [[nasal congestion]], and [[anosmia]].<ref name="pmid8272884">{{cite journal |vauthors=Greenspan A |title=Benign bone-forming lesions: osteoma, osteoid osteoma, and osteoblastoma. Clinical, imaging, pathologic, and differential considerations |journal=Skeletal Radiol. |volume=22 |issue=7 |pages=485–500 |year=1993 |pmid=8272884 |doi= |url=}}</ref>
The hallmark of osteoma is facial pain and [[headache]]. A positive history of [[Gardner syndrome]] is suggestive of multiple osteomas. Symptoms related with osteoma will vary depending on the size and location of the tumor. Small osteomas are asymptomatic and usually incidental findings. Conversely, common symptoms of large paranasal sinus osteomas may be [[headache]], [[nasal congestion]], and [[anosmia]].


===Physical Examination===
===Physical Examination===
Common physical examination findings of osteoma include the [[nasal discharge]], facial [[tenderness]], and facial deformity.<ref name="pmid8272884">{{cite journal |vauthors=Greenspan A |title=Benign bone-forming lesions: osteoma, osteoid osteoma, and osteoblastoma. Clinical, imaging, pathologic, and differential considerations |journal=Skeletal Radiol. |volume=22 |issue=7 |pages=485–500 |year=1993 |pmid=8272884 |doi= |url=}}</ref>
Common physical examination findings of osteoma include the [[nasal discharge]], facial [[tenderness]], and facial deformity.


===Laboratory Findings===
===Laboratory Findings===
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===X Ray===
===X Ray===
On x-ray, osteoma demonstrates a dense well circumscribed mass with varying amounts of central lucency. Caldwell and Waters view are the radiographic positions of choice for the evaluation of osteomas.<ref name="radio"> Paranasal sinus osteoma. Radiopedia.http://radiopaedia.org/articles/paranasal-sinus-osteoma Accessed on January 18, 2016</ref>
On x-ray, osteoma demonstrates a dense well circumscribed mass with varying amounts of central lucency. Caldwell and Waters view are the radiographic positions of choice for the evaluation of osteomas.


===CT===
===CT===
On CT scan, osteomas demonstrate a well circumscribed mass of variable density, varying from very dense (similar in density to normal cortical bone) to less dense with a ground-glass appearance.<ref name="radio"> Paranasal sinus osteoma. Radiopedia.http://radiopaedia.org/articles/paranasal-sinus-osteoma Accessed on January 18, 2016</ref>
On CT scan, osteomas demonstrate a well circumscribed mass of variable density, varying from very dense (similar in density to normal cortical bone) to less dense with a ground-glass appearance.


===MRI===
===MRI===
On MRI, ivory osteomas are low on all sequences. Mature osteomas may demonstrate some marrow signal, but are also predominantly low on all sequences.<ref name="radio"> Paranasal sinus osteoma. Radiopedia.http://radiopaedia.org/articles/paranasal-sinus-osteoma Accessed on January 18, 2016</ref>
On MRI, ivory osteomas are low on all sequences. Mature osteomas may demonstrate some marrow signal, but are also predominantly low on all sequences.


===Ultrasound===
===Ultrasound===
There are no ultrasound findings associated with osteoma.<ref name="radio"> Paranasal sinus osteoma. Radiopedia.http://radiopaedia.org/articles/paranasal-sinus-osteoma Accessed on January 18, 2016</ref>
There are no ultrasound findings associated with osteoma.


===Other Imaging Findings===
===Other Imaging Findings===
There are no other imaging findings associated with osteoma.<ref name="radio"> Paranasal sinus osteoma. Radiopedia.http://radiopaedia.org/articles/paranasal-sinus-osteoma Accessed on January 18, 2016</ref>
There are no other imaging findings associated with osteoma.


===Other Diagnostic Studies===
===Other Diagnostic Studies===
Other diagnostic study for osteoma is nasal endoscopy.<ref name="pmid19894552">{{cite journal |vauthors=Li Y, Zhang L, Zhou B, Han D |title=[Resection of frontal ethmoid sinus osteomas with nasal endoscopy] |language=Chinese |journal=Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi |volume=23 |issue=14 |pages=628–30 |year=2009 |pmid=19894552 |doi= |url=}}</ref> Biopsy may be obtained with nasal endoscopy, depending on the location of the tumor.<ref name="pmid25090813">{{cite journal |vauthors=Gotlib T, Held-Ziółkowska M, Niemczyk K |title=Frontal sinus and recess osteomas: an endonasal endoscopic approach |journal=B-ENT |volume=10 |issue=2 |pages=141–7 |year=2014 |pmid=25090813 |doi= |url=}}</ref>
Other diagnostic study for osteoma is nasal endoscopy. Biopsy may be obtained with nasal endoscopy, depending on the location of the tumor.


==Treatment==
==Treatment==


===Medical Therapy===
===Medical Therapy===
There is no medical treatment for osteoma; the mainstay of therapy is surgery.<ref name="prev"> Canadian Cancer Society. Benign tumours of the nasal cavity and paranasal sinuses.http://www.cancer.ca/en/cancer-information/cancer-type/nasal-paranasal/nasal-cavity-and-paranasal-sinus-cancer/benign-tumours/?region=bc#ixzz3xnya2BSM Accessed on January 20,2016</ref>
There is no medical treatment for osteoma; the mainstay of therapy is surgery.


===Surgery===
===Surgery===
Surgery is the mainstay of therapy. Surgical intervention is only recommended for the management of symptomatic osteoma.<ref name="prev"> Canadian Cancer Society. Benign tumours of the nasal cavity and paranasal sinuses.http://www.cancer.ca/en/cancer-information/cancer-type/nasal-paranasal/nasal-cavity-and-paranasal-sinus-cancer/benign-tumours/?region=bc#ixzz3xnya2BSM Accessed on January 20,2016</ref>
Surgery is the mainstay of therapy. Surgical intervention is only recommended for the management of symptomatic osteoma.


==Primary Prevention==
==Primary Prevention==
There is no primary prevention for osteoma.<ref name="prev"> Canadian Cancer Society. Benign tumours of the nasal cavity and paranasal sinuses.http://www.cancer.ca/en/cancer-information/cancer-type/nasal-paranasal/nasal-cavity-and-paranasal-sinus-cancer/benign-tumours/?region=bc#ixzz3xnya2BSM Accessed on January 20,2016</ref>
There is no primary prevention for osteoma.


==Secondary Prevention==
==Secondary Prevention==


Secondary prevention for osteoma includes screening for multiple osteomas among patients with family history or/and a confirmed diagnosis of Gardner syndrome. Thyroid exam and annual ultrasound, should be performed starting at age 10 to 12 years.<ref name="pmid24093640">{{cite journal |vauthors=Septer S, Slowik V, Morgan R, Dai H, Attard T |title=Thyroid cancer complicating familial adenomatous polyposis: mutation spectrum of at-risk individuals |journal=Hered Cancer Clin Pract |volume=11 |issue=1 |pages=13 |year=2013 |pmid=24093640 |pmc=3854022 |doi=10.1186/1897-4287-11-13 |url=}}</ref>
Secondary prevention for osteoma includes screening for multiple osteomas among patients with family history or/and a confirmed diagnosis of Gardner syndrome. Thyroid exam and annual ultrasound, should be performed starting at age 10 to 12 years.


==References==
==References==
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Latest revision as of 19:56, 1 June 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

Osteoma (also known as Osteomata) is a slow growing benign tumor of bone, occurring most commonly in the craniofacial skeletal structures, primarily in the nasal and paranasal (75-90%) cavities. Osteoma arises from bone overgrowth, which is normally composed of connective tissue. Osteomas are slow growing tumors composed of compact or mature trabecular bone limited to craniofacial bones. Osteoma may be incidentally identified as a mass in the skull, mandible, or as the underlying cause of sinusitis or mucocele formation within the paranasal sinuses. When they are multiple, Gardner syndrome should be considered. Osteoma represents the most common benign neoplasm of the nose and paranasal sinuses. The causes remain uncertain, but commonly accepted theories propose embryologic, traumatic, or infectious causes. Osteomas are usually asymptomatic. Excision may be performed if osteoma is responsible for symptoms.

Historical Perspective

In 1898, Paul Schulze, was the first to describe a craniofacial skeletal osteoma.

Classification

Osteoma may be classified into either sporadic or multiple forms. The different subtypes of osteoma include: ivory osteoma, mature osteoma, and mixed osteoma.

Pathophysiology

Osteoma is a slow growing benign tumor of bone, occurring most commonly in the craniofacial skeletal structures, primarily in the nasal and paranasal (75-90%) cavities. Osteoma arises from bone overgrowth, which is normally composed of connective tissue. Osteomas are slow growing tumors composed of compact or mature trabecular bone limited to craniofacial bones. The most common gene affected in multiple osteoma is the APC gene.

Causes

The cause of an osteoma has not been identified, but commonly accepted theories propose embryological, traumatic, or infective causes.

Differentiating Osteoma from other Diseases

Osteoma must be differentiated from other diseases that cause sinus or facial pain, headache, and changes to or loss of sense of smell, such as other osteogenic tumours, fibrous displasia, and chronic sinusitis.

Epidemiology and Demographics

Osteoma is the most common benign neoplasm of the nose and paranasal sinuses. The prevalence of osteoma is 3% in general population. It mainly affects adults and children. The mean age at diagnosis is 37 years. Men are more commonly affected than women, with a 3:2 ratio.

Risk Factors

The risk factors of osteoma remain unknown.

Screening

Screening for multiple osteomas is recommended among patients with family history or/and a confirmed diagnosis of Gardner syndrome. Thyroid exam and annual ultrasound, should be performed starting at age 10 to 12 years.

Natural History, Complications and Prognosis

If left untreated, osteoma progression occurs slowly and is then followed by facial distortion. Common sites of location include paranasal sinuses. Complications of osteoma are usually related to tumor size. The prognosis is regarded as excellent after surgical excision. Features associated with worse prognosis after surgery are tumor location, depth, and size.

Diagnosis

Staging

There is no established system for the staging of osteoma.

History and Symptoms

The hallmark of osteoma is facial pain and headache. A positive history of Gardner syndrome is suggestive of multiple osteomas. Symptoms related with osteoma will vary depending on the size and location of the tumor. Small osteomas are asymptomatic and usually incidental findings. Conversely, common symptoms of large paranasal sinus osteomas may be headache, nasal congestion, and anosmia.

Physical Examination

Common physical examination findings of osteoma include the nasal discharge, facial tenderness, and facial deformity.

Laboratory Findings

There are no diagnostic laboratory findings associated with osteoma.

X Ray

On x-ray, osteoma demonstrates a dense well circumscribed mass with varying amounts of central lucency. Caldwell and Waters view are the radiographic positions of choice for the evaluation of osteomas.

CT

On CT scan, osteomas demonstrate a well circumscribed mass of variable density, varying from very dense (similar in density to normal cortical bone) to less dense with a ground-glass appearance.

MRI

On MRI, ivory osteomas are low on all sequences. Mature osteomas may demonstrate some marrow signal, but are also predominantly low on all sequences.

Ultrasound

There are no ultrasound findings associated with osteoma.

Other Imaging Findings

There are no other imaging findings associated with osteoma.

Other Diagnostic Studies

Other diagnostic study for osteoma is nasal endoscopy. Biopsy may be obtained with nasal endoscopy, depending on the location of the tumor.

Treatment

Medical Therapy

There is no medical treatment for osteoma; the mainstay of therapy is surgery.

Surgery

Surgery is the mainstay of therapy. Surgical intervention is only recommended for the management of symptomatic osteoma.

Primary Prevention

There is no primary prevention for osteoma.

Secondary Prevention

Secondary prevention for osteoma includes screening for multiple osteomas among patients with family history or/and a confirmed diagnosis of Gardner syndrome. Thyroid exam and annual ultrasound, should be performed starting at age 10 to 12 years.

References

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