Novel human coronavirus infection overview

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Novel Human Coronavirus Infection from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Case Definitions

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

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Other Diagnostic Studies

Treatment

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Future or Investigational Therapies

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Novel human coronavirus is a new strain of coronavirus that has not been previously identified in humans. A previously unknown coronavirus was isolated from the sputum of a 60-year-old man who presented with acute pneumonia and subsequent renal failure with a fatal outcome in Saudi Arabia. A novel coronavirus (human betacoronavirus 2c EMC/2012) has caused a handful of infections in three countries in the Middle East. Although it does not seem to be transmitted between humans, it can cause severe disease and death, and scientists are watching closely for new cases.

Historical Perspective

The virus first emerged in the Middle East, and was discovered on September 2012 in a Qatari patient who had recently traveled to Saudi Arabia.[1] Virologist Ron Fouchier has speculated that the virus might originate from bats.[2]

Causes

Novel human coronavirus is a ssRNA positive-strand viruses with no DNA stage. It belongs to order Nidovirales, family Coronaviridae.

Differentiating Novel Human Coronavirus Infection from other Diseases

WHO recognizes that the emergence of a new coronavirus capable of causing severe disease raises concerns because of experience with SARS. Although this novel coronavirus is distantly related to the SARS CoV, they are different. Based on current information, it does not appear to transmit easily between people, unlike the SARS virus.

Diagnosis

History and Symptoms

In confirmed cases of illness in humans, common symptoms have been acute, serious respiratory illness with fever, cough, shortness of breath, and breathing difficulties. Based on current clinical experience, the infection generally presents as pneumonia. It is important to note that the current understanding of the illness caused by this infection is based on a limited number of cases and may change as more information becomes available.

=Laboratory Findings

Lab tests (polymerase chain reaction or PCR) for the novel coronavirus are available at CDC and other international labs. Otherwise, these tests are not routinely available.

Other Diagnostic Studies

The United Kingdom's Health Protection Agency is working on the genetic sequence of the virus, based on the sequence obtained from the Qatari case.[3]

References

  1. Nebehay, Stephanie (26 September 2012). "WHO issues guidance on new virus, gears up for haj". Reuters. Retrieved 27 September 2012.
  2. Doucleff, Michaeleen (28 September 2012). "Holy Bat Virus! Genome Hints At Origin Of SARS-Like Virus". NPR. Retrieved 29 September 2012.
  3. "How threatening is the new coronavirus?". BBC. 24 September 2012. Retrieved 27 September 2012.


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