Non small cell lung cancer natural history: Difference between revisions
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==Overview== | ==Overview== | ||
If left untreated, non-small cell lung cancer progression occurs slowly and is then followed by local invasion to [[lymph nodes]] and distant [[metastasis]].<ref name="pmid17356101">{{cite journal |vauthors=Soares M, Darmon M, Salluh JI, Ferreira CG, Thiéry G, Schlemmer B, Spector N, Azoulay E |title=Prognosis of lung cancer patients with life-threatening complications |journal=Chest |volume=131 |issue=3 |pages=840–6 |year=2007 |pmid=17356101 |doi=10.1378/chest.06-2244 |url=}}</ref> Non-small cell lung cancer is a locally aggressive tumor, commonly occurs in adult patients between 65 to 74 years. Common sites of metastasis include [[adrenal gland]], [[Bone tumors|bone]], [[brain]], and [[liver]]. Complications of non-small cell lung cancer | If left untreated, non-small cell lung cancer progression occurs slowly and is then followed by local invasion to [[lymph nodes]] and distant [[metastasis]].<ref name="pmid17356101">{{cite journal |vauthors=Soares M, Darmon M, Salluh JI, Ferreira CG, Thiéry G, Schlemmer B, Spector N, Azoulay E |title=Prognosis of lung cancer patients with life-threatening complications |journal=Chest |volume=131 |issue=3 |pages=840–6 |year=2007 |pmid=17356101 |doi=10.1378/chest.06-2244 |url=}}</ref> Non-small cell lung cancer is a locally aggressive tumor, commonly occurs in adult patients between 65 to 74 years. Common sites of metastasis include [[adrenal gland]], [[Bone tumors|bone]], [[brain]], and [[liver]]. Complications of non-small cell lung cancer, include: | ||
[[respiratory failure|Acute respiratory failure]], [[respiratory acidosis]], [[pleural effusion|malignant pleural effusion]], [[metastases]], and[[pneumonia]]. The 5-year relative survival of patients with non-small cell lung cancer is approximately 50%.<ref name="pmid17356101">{{cite journal |vauthors=Soares M, Darmon M, Salluh JI, Ferreira CG, Thiéry G, Schlemmer B, Spector N, Azoulay E |title=Prognosis of lung cancer patients with life-threatening complications |journal=Chest |volume=131 |issue=3 |pages=840–6 |year=2007 |pmid=17356101 |doi=10.1378/chest.06-2244 |url=}}</ref> Features associated with worse prognosis are presence of lymphatic invasion, location of lesion, gene expression profile, performance status, presence of satellite lesions, and presence of regional or distant metastases. Prognosis is generally regarded as poor with an all-stage average survival rate of 25%. The 5-year recurrence rate of non-small cell lung cancer is 24%.<ref name="pmid17356101">{{cite journal |vauthors=Soares M, Darmon M, Salluh JI, Ferreira CG, Thiéry G, Schlemmer B, Spector N, Azoulay E |title=Prognosis of lung cancer patients with life-threatening complications |journal=Chest |volume=131 |issue=3 |pages=840–6 |year=2007 |pmid=17356101 |doi=10.1378/chest.06-2244 |url=}}</ref> | |||
==Natural History== | ==Natural History== | ||
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* The symptoms of non-small cell lung cancer usually develop in adult patients between 65 to 74 years | * The symptoms of non-small cell lung cancer usually develop in adult patients between 65 to 74 years | ||
* Initially patients complain of [[Cough|chronic cough]], [[diaphoresis]], and [[weight-loss]] | * Initially patients complain of [[Cough|chronic cough]], [[diaphoresis]], and [[weight-loss]] | ||
* If left untreated, patients with non-small cell lung cancer may develop | * If left untreated, patients with non-small cell lung cancer may develop local invasion to lymph nodes and distant metastasis | ||
* Common sites of metastasis include [[adrenal gland]], [[Bone tumors|bone]], [[brain]], and [[liver] | |||
==Complications== | ==Complications== | ||
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==Prognosis== | ==Prognosis== | ||
* Non-small cell lung cancer prognosis and recurrence depends on the origin of primary tumor, histological type, and stage | * Non-small cell lung cancer prognosis and recurrence depends on the origin of primary tumor, histological type, and stage | ||
* Non-small cell lung cancer prognosis is generally regarded as poor | * Non-small cell lung cancer prognosis is generally regarded as poor | ||
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* The recurrence rate of non-small cell lung cancer is 24% | * The recurrence rate of non-small cell lung cancer is 24% | ||
* The median survival time of non-small cell lung cancer after a complication, such as malignant pleural effusion is 1 to 3 months.<ref name="pmid3183615">{{cite journal |vauthors=Phonimdaeng P, O'Reilly M, O'Toole PW, Foster TJ |title=Molecular cloning and expression of the coagulase gene of Staphylococcus aureus 8325-4 |journal=J. Gen. Microbiol. |volume=134 |issue=1 |pages=75–83 |year=1988 |pmid=3183615 |doi=10.1099/00221287-134-1-75 |url=}}</ref> | * The median survival time of non-small cell lung cancer after a complication, such as malignant pleural effusion is 1 to 3 months.<ref name="pmid3183615">{{cite journal |vauthors=Phonimdaeng P, O'Reilly M, O'Toole PW, Foster TJ |title=Molecular cloning and expression of the coagulase gene of Staphylococcus aureus 8325-4 |journal=J. Gen. Microbiol. |volume=134 |issue=1 |pages=75–83 |year=1988 |pmid=3183615 |doi=10.1099/00221287-134-1-75 |url=}}</ref> | ||
* | *Features associated with worse prognosis, include: | ||
:*Presence of lymphatic invasion | |||
:*Unfavorable genetic expression profile | |||
:*Location of lesion | |||
:*Performance status | |||
:*Presence of satellite lesions | |||
:*Presence of regional or distant metastases | |||
* The table below summarizes the 5-year survival rate according to non-small cell lung cancer stage: | * The table below summarizes the 5-year survival rate according to non-small cell lung cancer stage: | ||
Revision as of 17:10, 3 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2] Maria Fernanda Villarreal, M.D. [3]
Overview
If left untreated, non-small cell lung cancer progression occurs slowly and is then followed by local invasion to lymph nodes and distant metastasis.[1] Non-small cell lung cancer is a locally aggressive tumor, commonly occurs in adult patients between 65 to 74 years. Common sites of metastasis include adrenal gland, bone, brain, and liver. Complications of non-small cell lung cancer, include: Acute respiratory failure, respiratory acidosis, malignant pleural effusion, metastases, andpneumonia. The 5-year relative survival of patients with non-small cell lung cancer is approximately 50%.[1] Features associated with worse prognosis are presence of lymphatic invasion, location of lesion, gene expression profile, performance status, presence of satellite lesions, and presence of regional or distant metastases. Prognosis is generally regarded as poor with an all-stage average survival rate of 25%. The 5-year recurrence rate of non-small cell lung cancer is 24%.[1]
Natural History
- Most patients with non-small cell lung cancer are initially asymptomatic[1]
- The symptoms of non-small cell lung cancer usually develop in adult patients between 65 to 74 years
- Initially patients complain of chronic cough, diaphoresis, and weight-loss
- If left untreated, patients with non-small cell lung cancer may develop local invasion to lymph nodes and distant metastasis
- Common sites of metastasis include adrenal gland, bone, brain, and [[liver]
Complications
- Common complications of non-small cell lung cancer, include:[1]
Prognosis
- Non-small cell lung cancer prognosis and recurrence depends on the origin of primary tumor, histological type, and stage
- Non-small cell lung cancer prognosis is generally regarded as poor
- Non-small cell lung cancer survival rate ranges from 1 to 52% (stage I to stage IV)
- The recurrence rate of non-small cell lung cancer is 24%
- The median survival time of non-small cell lung cancer after a complication, such as malignant pleural effusion is 1 to 3 months.[2]
- Features associated with worse prognosis, include:
- Presence of lymphatic invasion
- Unfavorable genetic expression profile
- Location of lesion
- Performance status
- Presence of satellite lesions
- Presence of regional or distant metastases
- The table below summarizes the 5-year survival rate according to non-small cell lung cancer stage:
Stage 5-year survival rate IA 49% IB 45% IIA 30% IIB 31% IIIA 14% IIIB 5% IV 1%
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Soares M, Darmon M, Salluh JI, Ferreira CG, Thiéry G, Schlemmer B, Spector N, Azoulay E (2007). "Prognosis of lung cancer patients with life-threatening complications". Chest. 131 (3): 840–6. doi:10.1378/chest.06-2244. PMID 17356101.
- ↑ Phonimdaeng P, O'Reilly M, O'Toole PW, Foster TJ (1988). "Molecular cloning and expression of the coagulase gene of Staphylococcus aureus 8325-4". J. Gen. Microbiol. 134 (1): 75–83. doi:10.1099/00221287-134-1-75. PMID 3183615.