Non-Hodgkin lymphoma laboratory tests: Difference between revisions

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{{Non-Hodgkin lymphoma}}
{{Non-Hodgkin lymphoma}}
{{CMG}}; {{AE}} {{AS}}
{{CMG}} {{shyam}}; {{AE}} {{AS}}
==Overview==
==Overview==
Laboratory tests for Non-hodgkin lymphoma include [[complete blood count]] (CBC), blood chemistry studies, HIV blood test, and Hepatitis B blood test
Laboratory tests for non-Hodgkin lymphoma include [[complete blood count]] (CBC), blood chemistry studies, [[HIV]] blood test, and [[hepatitis B]] blood test.
==Laboratory Tests==
Laboratory tests for non-Hodgkin lymphoma include the following:<ref name="pmid26174528">{{cite journal| author=Sandlund JT| title=Non-Hodgkin Lymphoma in Children. | journal=Curr Hematol Malig Rep | year= 2015 | volume= 10 | issue= 3 | pages= 237-43 | pmid=26174528 | doi=10.1007/s11899-015-0277-y | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26174528  }} </ref><ref name="pmid22835603">{{cite journal| author=Shankland KR, Armitage JO, Hancock BW| title=Non-Hodgkin lymphoma. | journal=Lancet | year= 2012 | volume= 380 | issue= 9844 | pages= 848-57 | pmid=22835603 | doi=10.1016/S0140-6736(12)60605-9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22835603  }} </ref><ref name="pmid19999217">{{cite journal| author=Hingorjo MR, Syed S| title=Presentation, staging and diagnosis of lymphoma: a clinical perspective. | journal=J Ayub Med Coll Abbottabad | year= 2008 | volume= 20 | issue= 4 | pages= 100-3 | pmid=19999217 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19999217  }} </ref>
 
===Complete Blood Count===
* In early stage of the disease the [[complete blood count]] (CBC) may be normal.
*[[Anemia]] may be seen secondary to involvement of [[bone marrow]], [[Autoimmune hemolytic anemia|autoimmune hemolysis]] and bleeding.
*[[Thrombocytopenia]], [[leukopenia]], or [[pancytopenia]] may be seen after bone marrow infiltration or autoimmune cytopenias.
*[[Lymphocytosis]] with circulating malignant cells seen in low grade lymphomas.
*[[Thrombocytosis]] may be seen as a [[paraneoplastic syndrome]].
 
===Blood Chemistry Studies===
*Elevated [[lactate dehydrogenase]] (LDH) correlates with poor prognosis.
*[[Liver function test]] (LFT) results may be abnormal secondary to hepatic involvement.
*[[Hypercalcemia]] may be seen in patients with acute form of [[Adult T-cell leukemia|adult T-cell lymphoma-leukemia]] (ATLL).


==Laboratory Tests==
===Other Studies===
Laboratory tests for Non-hodgkin lymphoma include the following:<ref name=CCS>{{cite web | title = Canadian Cancer Society non-Hodgkin lymphoma | url = http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/diagnosis/?region=ab }}</ref>
*Increased levels of [[beta2-microglobulin]] level may be seen, which correlate with a poor prognosis.
*A  positive [[Coombs test]] may be positive.
*[[Hypogammaglobulinemia]] may be present.
*[[Human Immunodeficiency Virus (HIV)|HIV]]  viral load and the antibody titre may be elevated.
*[[HTLV-1]] serology should be obtained in patients with [[Adult T-cell leukemia|ATLL]].
*HbsAg and [[Hepatitis B|Hep B]] antibody titre must be obtained.


* [[Complete blood count]] (CBC) is done to:
:* Rule out infection
:* Assess how well the blood-forming organs (such as the bone marrow and spleen) are working and to see if Hodgkin's lymphoma cells have spread to the bone marrow
:* Provide a baseline for future blood counts taken during and after treatment
* Blood chemistry studies include:
:* Protein levels
:* [[Liver function tests]]
:* Kidney function tests
:* Uric acid level
* HIV blood test
* Hepatitis B blood test
==References==
==References==
{{reflist|2}}
{{reflist|2}}


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Latest revision as of 21:00, 21 January 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [3]

Overview

Laboratory tests for non-Hodgkin lymphoma include complete blood count (CBC), blood chemistry studies, HIV blood test, and hepatitis B blood test.

Laboratory Tests

Laboratory tests for non-Hodgkin lymphoma include the following:[1][2][3]

Complete Blood Count

Blood Chemistry Studies

Other Studies

References

  1. Sandlund JT (2015). "Non-Hodgkin Lymphoma in Children". Curr Hematol Malig Rep. 10 (3): 237–43. doi:10.1007/s11899-015-0277-y. PMID 26174528.
  2. Shankland KR, Armitage JO, Hancock BW (2012). "Non-Hodgkin lymphoma". Lancet. 380 (9844): 848–57. doi:10.1016/S0140-6736(12)60605-9. PMID 22835603.
  3. Hingorjo MR, Syed S (2008). "Presentation, staging and diagnosis of lymphoma: a clinical perspective". J Ayub Med Coll Abbottabad. 20 (4): 100–3. PMID 19999217.