Neutropenia pathophysiology: Difference between revisions

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==Pathophysiology==
==Pathophysiology==
Neutropenia develops as a result of one of the three following mechanisms:
'''1) Impaired granulocyte production'''
- Hematologic malignancy with bone marrow infiltration
- Myelosuppressive chemotherapy or other medications that are toxic to the bone marrow
- Nutritional deficiencies
'''2) Margination''' (process where free flowing blood cells exit circulation)
- Splenic sequestration
- Adherence to the vascular endothelium
'''3) Peripheral destruction'''
- Autoimmune hemolysis
- Drug-induced hemolysis


==References==
==References==

Revision as of 12:55, 26 September 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Overview

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Pathophysiology

Neutropenia develops as a result of one of the three following mechanisms:

1) Impaired granulocyte production

- Hematologic malignancy with bone marrow infiltration

- Myelosuppressive chemotherapy or other medications that are toxic to the bone marrow

- Nutritional deficiencies


2) Margination (process where free flowing blood cells exit circulation)

- Splenic sequestration

- Adherence to the vascular endothelium


3) Peripheral destruction

- Autoimmune hemolysis

- Drug-induced hemolysis

References

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