Neutropenia history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Daniel A. Gerber, M.D. [2]


Common symptoms of neutropenia include fever, frequent infections due to immunocompromization, and unusual redness, pain, or swelling around a wound.

History and Symptoms

History of patients with neutropenia should focus on symptoms suggestive of malignancy or infection, patient or family history of autoimmune or immunodeficiency disorders, risk factors for infections including HIV and hepatitis, and any unusual dietary practices or history of bariatric surgery. As a result, neutropenia may remain undetected until the patient develops secondary, and often severe, infections or sepsis. Some common infections can take an unexpected course in neutropenic patients; for example, formation of pus can be notably absent, as this requires circulating neutrophil granulocytes.[1]

Common symptoms of neutropenia include:


  1. Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, Raad II, Rolston KV, Young JA, Wingard JR; Infectious Diseases Society of America. (2011). "Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america". Clin Infect Dis. 52 (4): e56–95. PMID 21258094.