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{{ Neutropenia }}
{{Neutropenia}}
{{CMG}} {{AE}} {{DG}}


{{CMG}}
==Overview==
Common symptoms of [[neutropenia]] include [[fever]], frequent [[infections]] due to [[Immunocompromised|immunocompromization]], and unusual [[redness]], [[pain]], or [[swelling]] around a wound.


==Overview==
==History and Symptoms==
==History and Symptoms==
Neutropenia can go undetected until the patient develops secondary, and often severe, [[infection]]s or [[sepsis]]. Some common infections can take an unexpected course in neutropenic patients; formation of [[pus]], for example, can be notably absent, as this requires circulating neutrophil granulocytes. 
History of patients with [[neutropenia]] should focus on symptoms suggestive of [[malignancy]] or [[infection]], patient or family history of autoimmune or [[immunodeficiency]] disorders, risk factors for [[infections]] including [[HIV]] and [[hepatitis]], and any unusual dietary practices or history of [[bariatric surgery]]. As a result, neutropenia may remain undetected until the patient develops secondary, and often severe, [[infection]]s or [[sepsis]]. Some common infections can take an unexpected course in neutropenic patients; for example, formation of [[pus]] can be notably absent, as this requires circulating neutrophil granulocytes.<ref name="PMID21258094">{{cite journal |author=Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, Raad II, Rolston KV, Young JA, Wingard JR; Infectious Diseases Society of America. |title=Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america|journal=Clin Infect Dis. |volume=52 |issue=4 |pages=e56-95 |year=2011 |pmid=21258094 |doi=|url=http://www.ncbi.nlm.nih.gov/pubmed/21258094}}</ref>
History should focus on symptoms suggestive of malignancy or infections, patient or family history of autoimmune or [[immunodeficiency]] disorders, risk factors for infections including [[HIV]] and [[hepatitis]], and any unusual dietary practices or history of [[bariatric surgery]]. Medications should be reviewed with particular attention to chemotherapeutics, antibiotics, [[antiepileptics]], and psychoactive drugs as well as documenting any new medications started within the preceding few months.  


 
Common symptoms of neutropenia include:
Common presenting symptoms in neutropenic patients include:
*[[Fever]]
*[[Fever]]
*Frequent [[infections]] due to lessened ability to fight [[bacterial]] infections
*Frequent [[infections]] due to [[Immunocompromised|immunocompromization]]
*Unusual [[redness]], [[pain]], or [[swelling]] around a wound
*Mouth [[ulcers]]
*Mouth [[ulcers]]
*[[Diarrhea]]
*[[Diarrhea]]
*[[Burning sensation when urinating]]
*[[Burning sensation when urinating]]
*Unusual redness, pain, or [[swelling]] around a wound
*[[Sore throat]]
*[[Sore throat]]
*[[Shortness of breath]]
*[[Shortness of breath]]
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==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Disease]]
[[Category:Hematology]]
[[Category:Overview complete]]
{{WH}}
{{WS}}

Latest revision as of 00:37, 17 November 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Daniel A. Gerber, M.D. [2]

Overview

Common symptoms of neutropenia include fever, frequent infections due to immunocompromization, and unusual redness, pain, or swelling around a wound.

History and Symptoms

History of patients with neutropenia should focus on symptoms suggestive of malignancy or infection, patient or family history of autoimmune or immunodeficiency disorders, risk factors for infections including HIV and hepatitis, and any unusual dietary practices or history of bariatric surgery. As a result, neutropenia may remain undetected until the patient develops secondary, and often severe, infections or sepsis. Some common infections can take an unexpected course in neutropenic patients; for example, formation of pus can be notably absent, as this requires circulating neutrophil granulocytes.[1]

Common symptoms of neutropenia include:

References

  1. Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, Raad II, Rolston KV, Young JA, Wingard JR; Infectious Diseases Society of America. (2011). "Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america". Clin Infect Dis. 52 (4): e56–95. PMID 21258094.