Neuropilin 1

Neuropilin 1
File:PBB Protein NRP1 image.jpg PDB rendering based on 1kex.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1kex​, 2orx​, 2orz​
Identifiers
Symbols	NRP1 ; NRP; CD304; DKFZp686A03134; DKFZp781F1414; VEGF165R
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2876
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NRP1 212298 at tn.png
File:PBB GE NRP1 210510 s at tn.png
File:PBB GE NRP1 210615 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Neuropilin 1, also known as NRP1, is a human gene.. This is one of two human neuropilins.

NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM]

Further reading

• Zachary I, Gliki G (2001). "Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family". Cardiovasc. Res. 49 (3): 568–81. PMID 11166270.
• He Z, Tessier-Lavigne M (1997). "Neuropilin is a receptor for the axonal chemorepellent Semaphorin III". Cell. 90 (4): 739–51. PMID 9288753.
• Chen H, Chédotal A, He Z; et al. (1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron. 19 (3): 547–59. PMID 9331348.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Soker S, Takashima S, Miao HQ; et al. (1998). "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor". Cell. 92 (6): 735–45. PMID 9529250.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Giger RJ, Urquhart ER, Gillespie SK; et al. (1999). "Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity". Neuron. 21 (5): 1079–92. PMID 9856463.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen H, He Z, Bagri A, Tessier-Lavigne M (1999). "Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins". Neuron. 21 (6): 1283–90. PMID 9883722.CS1 maint: Multiple names: authors list (link)
• Takahashi T, Nakamura F, Jin Z; et al. (1999). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors". Nat. Neurosci. 1 (6): 487–93. doi:10.1038/2203. PMID 10196546.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rossignol M, Beggs AH, Pierce EA, Klagsbrun M (1999). "Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively". Genomics. 57 (3): 459–60. doi:10.1006/geno.1999.5790. PMID 10329017.CS1 maint: Multiple names: authors list (link)
• Makinen T, Olofsson B, Karpanen T; et al. (1999). "Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1". J. Biol. Chem. 274 (30): 21217–22. PMID 10409677.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cai H, Reed RR (1999). "Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1". J. Neurosci. 19 (15): 6519–27. PMID 10414980.
• Takahashi T, Fournier A, Nakamura F; et al. (1999). "Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors". Cell. 99 (1): 59–69. PMID 10520994.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tamagnone L, Artigiani S, Chen H; et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. PMID 10520995.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gagnon ML, Bielenberg DR, Gechtman Z; et al. (2000). "Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2573–8. doi:10.1073/pnas.040337597. PMID 10688880.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (2000). "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]". J. Biol. Chem. 275 (24): 18040–5. doi:10.1074/jbc.M909259199. PMID 10748121.CS1 maint: Multiple names: authors list (link)
• Fuh G, Garcia KC, de Vos AM (2000). "The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1". J. Biol. Chem. 275 (35): 26690–5. doi:10.1074/jbc.M003955200. PMID 10842181.CS1 maint: Multiple names: authors list (link)
• Rossignol M, Gagnon ML, Klagsbrun M (2001). "Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms". Genomics. 70 (2): 211–22. doi:10.1006/geno.2000.6381. PMID 11112349.CS1 maint: Multiple names: authors list (link)
• Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Whitaker GB, Limberg BJ, Rosenbaum JS (2001). "Vascular endothelial growth factor receptor-2 and neuropilin-1 form a receptor complex that is responsible for the differential signaling potency of VEGF(165) and VEGF(121)". J. Biol. Chem. 276 (27): 25520–31. doi:10.1074/jbc.M102315200. PMID 11333271.CS1 maint: Multiple names: authors list (link)
• Walter JW, North PE, Waner M; et al. (2002). "Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma". Genes Chromosomes Cancer. 33 (3): 295–303. PMID 11807987.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)