NPEPPS

Aminopeptidase puromycin sensitive
Identifiers
Symbols	NPEPPS ; PSA; MP100
External IDs	Template:OMIM5 Template:MGI HomoloGene: 36199
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Aminopeptidase puromycin sensitive, also known as NPEPPS, is a human gene.

This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle.

Further reading

• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thompson MW, Hersh LB (2005). "Analysis of conserved residues of the human puromycin-sensitive aminopeptidase". Peptides. 24 (9): 1359–65. PMID 14706550.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bauer WO, Nanda I, Beck G; et al. (2001). "Human puromycin-sensitive aminopeptidase: cloning of 3' UTR, evidence for a polymorphism at a.a. 140 and refined chromosomal localization to 17q21". Cytogenet. Cell Genet. 92 (3–4): 221–4. PMID 11435692.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de Gandarias JM, Irazusta J, Gil J; et al. (1999). "Ontogeny of puromycin-sensitive and insensitive aminopeptidase activities in several subcellular fractions of the rat brain". Brain Res. Bull. 50 (4): 283–90. PMID 10582526.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thompson MW, Tobler A, Fontana A, Hersh LB (1999). "Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase". Biochem. Biophys. Res. Commun. 258 (2): 234–40. doi:10.1006/bbrc.1999.0604. PMID 10329370.CS1 maint: Multiple names: authors list (link)
• Huber G, Thompson A, Grüninger F; et al. (1999). "cDNA cloning and molecular characterization of human brain metalloprotease MP100: a beta-secretase candidate?". J. Neurochem. 72 (3): 1215–23. PMID 10037494.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tobler AR, Constam DB, Schmitt-Gräff A; et al. (1997). "Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons". J. Neurochem. 68 (3): 889–97. PMID 9048733.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Cussenot O, Berthon P, Cochand-Priollet B; et al. (1994). "Immunocytochemical comparison of cultured normal epithelial prostatic cells with prostatic tissue sections". Exp. Cell Res. 214 (1): 83–92. doi:10.1006/excr.1994.1236. PMID 8082751.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Constam DB, Tobler AR, Rensing-Ehl A; et al. (1995). "Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization". J. Biol. Chem. 270 (45): 26931–9. PMID 7592939.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McLellan S, Dyer SH, Rodriguez G, Hersh LB (1988). "Studies on the tissue distribution of the puromycin-sensitive enkephalin-degrading aminopeptidases". J. Neurochem. 51 (5): 1552–9. PMID 3171591.CS1 maint: Multiple names: authors list (link)