NFIA: Difference between revisions

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{{for|the airport in Niagara Falls, New York|Niagara Falls International Airport}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Nuclear factor 1 A-type''' is a [[protein]] that in [[Human|humans]] is [[Genetic code|encoded]] by the ''NFIA'' [[gene]].<ref name="pmid7590749">{{cite journal | vauthors = Qian F, Kruse U, Lichter P, Sippel AE | title = Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH | journal = Genomics | volume = 28 | issue = 1 | pages = 66–73 | date = July 1995 | pmid = 7590749 | pmc = | doi = 10.1006/geno.1995.1107 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NFIA nuclear factor I/A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4774| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nuclear factor I/A
| HGNCid = 7784
| Symbol = NFIA
| AltSymbols =; DKFZp434L0422; KIAA1439; NFI-L
| OMIM = 600727
| ECnumber = 
| Homologene = 4086
| MGIid = 108056
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0020037 |text = heme binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0019079 |text = viral genome replication}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4774
    | Hs_Ensembl = ENSG00000162599
    | Hs_RefseqProtein = NP_005586
    | Hs_RefseqmRNA = NM_005595
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 61103519
    | Hs_GenLoc_end = 61701053
    | Hs_Uniprot = Q12857
    | Mm_EntrezGene = 18027
    | Mm_Ensembl = ENSMUSG00000028565
    | Mm_RefseqmRNA = NM_010905
    | Mm_RefseqProtein = NP_035035
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 97073995
    | Mm_GenLoc_end = 97610889
    | Mm_Uniprot = Q3UTK6
  }}
}}
'''Nuclear factor I/A''', also known as '''NFIA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NFIA nuclear factor I/A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4774| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Nuclear factor I (NFI) proteins constitute a family of dimeric [[DNA-binding protein|DNA-binding proteins]] with similar, and possibly identical, DNA-binding specificity. They function as cellular [[transcription factor|transcription factors]] and as replication factors for [[adenovirus]] [[DNA replication]]. Diversity in this protein family is generated by multiple [[gene|genes]], differential [[RNA splicing|splicing]], and heterodimerization.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: NFIA nuclear factor I/A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4774| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = Nuclear factor I (NFI) proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity. They function as cellular transcription factors and as replication factors for adenovirus DNA replication. Diversity in this protein family is generated by multiple genes, differential splicing, and heterodimerization.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: NFIA nuclear factor I/A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4774| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Leahy P, Crawford DR, Grossman G, Gronostajski RM, Hanson RW | title = CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription | journal = The Journal of Biological Chemistry | volume = 274 | issue = 13 | pages = 8813–22 | date = March 1999 | pmid = 10085123 | doi = 10.1074/jbc.274.13.8813 }}
| citations =
* {{cite journal | vauthors = das Neves L, Duchala CS, Tolentino-Silva F, Haxhiu MA, Colmenares C, Macklin WB, Campbell CE, Butz KG, Gronostajski RM, Godinho F | title = Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 21 | pages = 11946–51 | date = October 1999 | pmid = 10518556 | pmc = 18392 | doi = 10.1073/pnas.96.21.11946 }}
*{{cite journal  | author=Qian F, Kruse U, Lichter P, Sippel AE |title=Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. |journal=Genomics |volume=28 |issue= 1 |pages= 66-73 |year= 1995 |pmid= 7590749 |doi= 10.1006/geno.1995.1107 }}
* {{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 7 | issue = 1 | pages = 65–73 | date = February 2000 | pmid = 10718198 | doi = 10.1093/dnares/7.1.65 }}
*{{cite journal | author=Leahy P, Crawford DR, Grossman G, ''et al.'' |title=CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8813-22 |year= 1999 |pmid= 10085123 |doi= }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = August 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=das Neves L, Duchala CS, Tolentino-Silva F, ''et al.'' |title=Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 21 |pages= 11946-51 |year= 1999 |pmid= 10518556 |doi= }}
* {{cite journal | vauthors = Xu H, Uno JK, Inouye M, Collins JF, Ghishan FK | title = NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene | journal = American Journal of Physiology. Gastrointestinal and Liver Physiology | volume = 288 | issue = 2 | pages = G175-81 | date = February 2005 | pmid = 15458926 | doi = 10.1152/ajpgi.00396.2004 }}
*{{cite journal | author=Nagase T, Kikuno R, Ishikawa KI, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65-73 |year= 2000 |pmid= 10718198 |doi=  }}
* {{cite journal | vauthors = Wang W, Stock RE, Gronostajski RM, Wong YW, Schachner M, Kilpatrick DL | title = A role for nuclear factor I in the intrinsic control of cerebellar granule neuron gene expression | journal = The Journal of Biological Chemistry | volume = 279 | issue = 51 | pages = 53491–7 | date = December 2004 | pmid = 15466411 | doi = 10.1074/jbc.M410370200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Champ PC, Maurice S, Vargason JM, Camp T, Ho PS | title = Distributions of Z-DNA and nuclear factor I in human chromosome 22: a model for coupled transcriptional regulation | journal = Nucleic Acids Research | volume = 32 | issue = 22 | pages = 6501–10 | year = 2005 | pmid = 15598822 | pmc = 545456 | doi = 10.1093/nar/gkh988 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Berry FB, O'Neill MA, Coca-Prados M, Walter MA | title = FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner | journal = Molecular and Cellular Biology | volume = 25 | issue = 4 | pages = 1415–24 | date = February 2005 | pmid = 15684392 | pmc = 548007 | doi = 10.1128/MCB.25.4.1415-1424.2005 }}
*{{cite journal | author=Xu H, Uno JK, Inouye M, ''et al.'' |title=NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=288 |issue= 2 |pages= G175-81 |year= 2005 |pmid= 15458926 |doi= 10.1152/ajpgi.00396.2004 }}
* {{cite journal | vauthors = Fazi F, Rosa A, Fatica A, Gelmetti V, De Marchis ML, Nervi C, Bozzoni I | title = A minicircuitry {{sic|comprised |hide=y|of}} microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis | journal = Cell | volume = 123 | issue = 5 | pages = 819–31 | date = December 2005 | pmid = 16325577 | doi = 10.1016/j.cell.2005.09.023 }}
*{{cite journal | author=Wang W, Stock RE, Gronostajski RM, ''et al.'' |title=A role for nuclear factor I in the intrinsic control of cerebellar granule neuron gene expression. |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53491-7 |year= 2005 |pmid= 15466411 |doi= 10.1074/jbc.M410370200 }}
* {{cite journal | vauthors = Lin YL, Wang YH, Lee HJ | title = Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A | journal = Biochemical and Biophysical Research Communications | volume = 350 | issue = 2 | pages = 430–6 | date = November 2006 | pmid = 17010934 | doi = 10.1016/j.bbrc.2006.09.061 }}
*{{cite journal | author=Champ PC, Maurice S, Vargason JM, ''et al.'' |title=Distributions of Z-DNA and nuclear factor I in human chromosome 22: a model for coupled transcriptional regulation. |journal=Nucleic Acids Res. |volume=32 |issue= 22 |pages= 6501-10 |year= 2005 |pmid= 15598822 |doi= 10.1093/nar/gkh988 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Berry FB, O'Neill MA, Coca-Prados M, Walter MA |title=FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner. |journal=Mol. Cell. Biol. |volume=25 |issue= 4 |pages= 1415-24 |year= 2005 |pmid= 15684392 |doi= 10.1128/MCB.25.4.1415-1424.2005 }}
* {{cite journal | vauthors = Lu W, Quintero-Rivera F, Fan Y, Alkuraya FS, Donovan DJ, Xi Q, Turbe-Doan A, Li QG, Campbell CG, Shanske AL, Sherr EH, Ahmad A, Peters R, Rilliet B, Parvex P, Bassuk AG, Harris DJ, Ferguson H, Kelly C, Walsh CA, Gronostajski RM, Devriendt K, Higgins A, Ligon AH, Quade BJ, Morton CC, Gusella JF, Maas RL | title = NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects | journal = PLoS Genetics | volume = 3 | issue = 5 | pages = e80 | date = May 2007 | pmid = 17530927 | pmc = 1877820 | doi = 10.1371/journal.pgen.0030080 }}
*{{cite journal | author=Fazi F, Rosa A, Fatica A, ''et al.'' |title=A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. |journal=Cell |volume=123 |issue= 5 |pages= 819-31 |year= 2006 |pmid= 16325577 |doi= 10.1016/j.cell.2005.09.023 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Lin YL, Wang YH, Lee HJ |title=Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A. |journal=Biochem. Biophys. Res. Commun. |volume=350 |issue= 2 |pages= 430-6 |year= 2006 |pmid= 17010934 |doi= 10.1016/j.bbrc.2006.09.061 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Lu W, Quintero-Rivera F, Fan Y, ''et al.'' |title=NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects. |journal=PLoS Genet. |volume=3 |issue= 5 |pages= e80 |year= 2007 |pmid= 17530927 |doi= 10.1371/journal.pgen.0030080 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|NFIA+protein,+human}}
* {{MeshName|NFIA+protein,+human}}


{{NLM content}}
{{Transcription factors|g1}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
{{gene-1-stub}}

Latest revision as of 13:01, 31 October 2017

For the airport in Niagara Falls, New York, see Niagara Falls International Airport.
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nuclear factor 1 A-type is a protein that in humans is encoded by the NFIA gene.[1][2]

Function

Nuclear factor I (NFI) proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity. They function as cellular transcription factors and as replication factors for adenovirus DNA replication. Diversity in this protein family is generated by multiple genes, differential splicing, and heterodimerization.[supplied by OMIM][2]

References

  1. ↑ Qian F, Kruse U, Lichter P, Sippel AE (July 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.
  2. ↑ 2.0 2.1 "Entrez Gene: NFIA nuclear factor I/A".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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