NCOA6: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Nuclear receptor coactivator 6''' is a [[protein]] that in humans is encoded by the ''NCOA6'' [[gene]].<ref name="pmid8724849">{{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N | title = Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Res | volume = 3 | issue = 1 | pages = 17–24 | date = November 1996 | pmid = 8724849 | pmc =  | doi = 10.1093/dnares/3.1.17 }}</ref><ref name="pmid8263591">{{cite journal | vauthors = Estey A, Kemp M, Allison S, Lamb C | title = Evaluation of a patient information booklet | journal = J Nurs Staff Dev | volume = 9 | issue = 6 | pages = 278–82 | date = January 1994 | pmid = 8263591 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NCOA6 nuclear receptor coactivator 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23054| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nuclear receptor coactivator 6
| HGNCid = 15936
| Symbol = NCOA6
| AltSymbols =; HOXA7; ANTP; HOX1.1; PRIP; TRBP; AIB3; ASC2; KIAA0181; NRC; RAP250
| OMIM = 605299
| ECnumber = 
| Homologene = 40920
| MGIid = 1929915
| GeneAtlas_image1 = PBB_GE_NCOA6_208979_at_tn.png
| Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030331 |text = estrogen receptor binding}} {{GNF_GO|id=GO:0030374 |text = ligand-dependent nuclear receptor transcription coactivator activity}} {{GNF_GO|id=GO:0046965 |text = retinoid X receptor binding}} {{GNF_GO|id=GO:0046966 |text = thyroid hormone receptor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006310 |text = DNA recombination}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006367 |text = transcription initiation from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0009725 |text = response to hormone stimulus}} {{GNF_GO|id=GO:0030099 |text = myeloid cell differentiation}} {{GNF_GO|id=GO:0030520 |text = estrogen receptor signaling pathway}} {{GNF_GO|id=GO:0042921 |text = glucocorticoid receptor signaling pathway}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23054
    | Hs_Ensembl = ENSG00000198646
    | Hs_RefseqProtein = NP_054790
    | Hs_RefseqmRNA = NM_014071
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 32766239
    | Hs_GenLoc_end = 32877094
    | Hs_Uniprot = Q14686
    | Mm_EntrezGene = 56406
    | Mm_Ensembl = ENSMUSG00000038369
    | Mm_RefseqmRNA = NM_019825
    | Mm_RefseqProtein = NP_062799
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 155082112
    | Mm_GenLoc_end = 155132224
    | Mm_Uniprot = Q3TAG3
  }}
}}
'''Nuclear receptor coactivator 6''', also known as '''NCOA6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NCOA6 nuclear receptor coactivator 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23054| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The [[protein]] encoded by this gene is a [[transcriptional]] [[coactivator]] that can interact with [[Cell nucleus|nuclear]] [[hormone]] receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D<sub>3</sub>, thyroid hormone, and [[steroid]] receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, [[histone acetyltransferase]]s, and [[methyltransferase]]s.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.<ref name="entrez">{{cite web | title = Entrez Gene: NCOA6 nuclear receptor coactivator 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23054| accessdate = }}</ref>
}}


==See also==
== Interactions ==
NCOA6 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[ASCL2]]<ref name = pmid12482968/> and
* [[Activating transcription factor 2]],<ref name = pmid14734562>{{cite journal | vauthors = Hong S, Choi HM, Park MJ, Kim YH, Choi YH, Kim HH, Choi YH, Cheong J | title = Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid | journal = J. Biol. Chem. | volume = 279 | issue = 17 | pages = 16996–7003 | date = April 2004 | pmid = 14734562 | doi = 10.1074/jbc.M311752200 }}</ref>
* [[Androgen receptor]],<ref name = pmid14645241/>
* [[CREB-binding protein]],<ref name = pmid10567404>{{cite journal | vauthors = Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW | title = A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo | journal = J. Biol. Chem. | volume = 274 | issue = 48 | pages = 34283–93 | date = November 1999 | pmid = 10567404 | doi = 10.1074/jbc.274.48.34283 }}</ref><ref name = pmid11158331>{{cite journal | vauthors = Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW | title = Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2 | journal = Mol. Endocrinol. | volume = 15 | issue = 2 | pages = 241–54 | date = February 2001 | pmid = 11158331 | doi = 10.1210/me.15.2.241 }}</ref>
* [[DNA-PKcs]],<ref name = pmid10823961/>
* [[E2F1]],<ref name = pmid14638867>{{cite journal | vauthors = Kong HJ, Yu HJ, Hong S, Park MJ, Choi YH, An WG, Lee JW, Cheong J | title = Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation | journal = Mol. Cancer Res. | volume = 1 | issue = 13 | pages = 948–58 | date = November 2003 | pmid = 14638867 | doi =  }}</ref>
* [[EP300]],<ref name = pmid10823961/>
* [[Estrogen receptor alpha]],<ref name = pmid10567404/><ref name = pmid11773444/>
* [[Estrogen receptor beta]],<ref name = pmid11158331/><ref name = pmid11773444/>
* [[HBXIP]],<ref name = pmid14578865>{{cite journal | vauthors = Kong HJ, Park MJ, Hong S, Yu HJ, Lee YC, Choi YH, Cheong J | title = Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2 | journal = Hepatology | volume = 38 | issue = 5 | pages = 1258–66 | date = November 2003 | pmid = 14578865 | doi = 10.1053/jhep.2003.50451 }}</ref>
* [[HIST2H3C]],<ref name = pmid12482968/>
* [[HSF1]],<ref name = pmid14960326>{{cite journal | vauthors = Hong S, Kim SH, Heo MA, Choi YH, Park MJ, Yoo MA, Kim HD, Kang HS, Cheong J | title = Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock | journal = FEBS Lett. | volume = 559 | issue = 1-3 | pages = 165–70 | date = February 2004 | pmid = 14960326 | doi = 10.1016/S0014-5793(04)00028-6 }}</ref>
* [[Ku70]],<ref name = pmid10823961>{{cite journal | vauthors = Ko L, Cardona GR, Chin WW | title = Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 11 | pages = 6212–7 | date = May 2000 | pmid = 10823961 | pmc = 18584 | doi = 10.1073/pnas.97.11.6212 }}</ref><ref name = pmid12519782>{{cite journal | vauthors = Ko L, Chin WW | title = Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase | journal = J. Biol. Chem. | volume = 278 | issue = 13 | pages = 11471–9 | date = March 2003 | pmid = 12519782 | doi = 10.1074/jbc.M209723200 }}</ref>
* [[Ku80]],<ref name = pmid10823961/><ref name = pmid12519782/>
* [[Liver X receptor beta]],<ref name = pmid11158331/>
* [[MLL3]],<ref name = pmid12482968/>
* [[RBBP5]],<ref name = pmid12482968>{{cite journal | vauthors = Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW | title = Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins | journal = Mol. Cell. Biol. | volume = 23 | issue = 1 | pages = 140–9 | date = January 2003 | pmid = 12482968 | pmc = 140670 | doi = 10.1128/mcb.23.1.140-149.2003 }}</ref>
* [[Retinoblastoma protein]],<ref name = pmid14645241>{{cite journal | vauthors = Goo YH, Na SY, Zhang H, Xu J, Hong S, Cheong J, Lee SK, Lee JW | title = Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation | journal = J. Biol. Chem. | volume = 279 | issue = 8 | pages = 7131–5 | date = February 2004 | pmid = 14645241 | doi = 10.1074/jbc.M312563200 }}</ref>
* [[Retinoic acid receptor alpha]],<ref name = pmid10567404/><ref name = pmid11158331/><ref name = pmid10823961/>
* [[Retinoid X receptor alpha]],<ref name = pmid10567404/><ref name = pmid11158331/><ref name = pmid11773444/><ref name = pmid14578865/>
* [[Src (gene)|Src]],<ref name = pmid12482968/><ref name = pmid10567404/><ref name = pmid11158331/><ref name = pmid10847592>{{cite journal | vauthors = Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW | title = Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2 | journal = Mol. Endocrinol. | volume = 14 | issue = 6 | pages = 915–25 | date = June 2000 | pmid = 10847592 | doi = 10.1210/mend.14.6.0471 }}</ref>
* [[TGS1]],<ref name = pmid11912212>{{cite journal | vauthors = Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK | title = Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation | journal = J. Biol. Chem. | volume = 277 | issue = 22 | pages = 20011–9 | date = May 2002 | pmid = 11912212 | doi = 10.1074/jbc.M201739200 }}</ref><ref name = pmid11517327>{{cite journal | vauthors = Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK | title = Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 18 | pages = 10380–5 | date = August 2001 | pmid = 11517327 | pmc = 56969 | doi = 10.1073/pnas.181347498 }}</ref>
* [[TUBA4A]],<ref name = pmid12482968/>
* [[TUBB]],<ref name = pmid12482968/>
* [[Thyroid hormone receptor alpha]],<ref name = pmid10567404/><ref name = pmid10847592/>  and
* [[Thyroid hormone receptor beta]].<ref name = pmid10567404/><ref name = pmid11158331/><ref name = pmid10823961/><ref name = pmid11773444>{{cite journal | vauthors = Ko L, Cardona GR, Iwasaki T, Bramlett KS, Burris TP, Chin WW | title = Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs | journal = Mol. Endocrinol. | volume = 16 | issue = 1 | pages = 128–40 | date = January 2002 | pmid = 11773444 | doi = 10.1210/mend.16.1.0755 }}</ref>
{{Div col end}}
 
== See also ==
* [[Transcription coregulator]]
* [[Transcription coregulator]]
{{Clear}}


==References==
== References ==
{{reflist|2}}
{{reflist|35em}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|35em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Mahajan MA, Samuels HH | title = A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein | journal = Mol. Cell. Biol. | volume = 20 | issue = 14 | pages = 5048–63 | date = July 2000 | pmid = 10866662 | pmc = 85955 | doi = 10.1128/MCB.20.14.5048-5063.2000 | url =  | issn =  }}
| citations =
* {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Res. | volume = 9 | issue = 3 | pages = 99–106 | year = 2003 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
* {{cite journal | vauthors = Carney JP, McKnight C, VanEpps S, Kelley MR | title = Random rapid amplification of cDNA ends (RRACE) allows for cloning of multiple novel human cDNA fragments containing (CAG)n repeats | journal = Gene | volume = 155 | issue = 2 | pages = 289–92 | year = 1995 | pmid = 7536696 | doi = 10.1016/0378-1119(94)00758-K }}
*{{cite journal | author=Carney JP, McKnight C, VanEpps S, Kelley MR |title=Random rapid amplification of cDNA ends (RRACE) allows for cloning of multiple novel human cDNA fragments containing (CAG)n repeats. |journal=Gene |volume=155 |issue= 2 |pages= 289-92 |year= 1995 |pmid= 7536696 |doi= }}
* {{cite journal | vauthors = Guan XY, Xu J, Anzick SL, Zhang H, Trent JM, Meltzer PS | title = Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer | journal = Cancer Res. | volume = 56 | issue = 15 | pages = 3446–50 | year = 1996 | pmid = 8758910 | doi =  }}
*{{cite journal | author=Nagase T, Seki N, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=3 |issue= 1 |pages= 17-24 |year= 1996 |pmid= 8724849 |doi= }}
* {{cite journal | vauthors = Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW | title = A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo | journal = J. Biol. Chem. | volume = 274 | issue = 48 | pages = 34283–93 | year = 1999 | pmid = 10567404 | doi = 10.1074/jbc.274.48.34283 }}
*{{cite journal | author=Guan XY, Xu J, Anzick SL, ''et al.'' |title=Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer. |journal=Cancer Res. |volume=56 |issue= 15 |pages= 3446-50 |year= 1996 |pmid= 8758910 |doi=  }}
* {{cite journal | vauthors = Caira F, Antonson P, Pelto-Huikko M, Treuter E, Gustafsson JA | title = Cloning and characterization of RAP250, a novel nuclear receptor coactivator | journal = J. Biol. Chem. | volume = 275 | issue = 8 | pages = 5308–17 | year = 2000 | pmid = 10681503 | doi = 10.1074/jbc.275.8.5308 }}
*{{cite journal | author=Lee SK, Anzick SL, Choi JE, ''et al.'' |title=A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. |journal=J. Biol. Chem. |volume=274 |issue= 48 |pages= 34283-93 |year= 1999 |pmid= 10567404 |doi= }}
* {{cite journal | vauthors = Zhu Y, Kan L, Qi C, Kanwar YS, Yeldandi AV, Rao MS, Reddy JK | title = Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR | journal = J. Biol. Chem. | volume = 275 | issue = 18 | pages = 13510–6 | year = 2000 | pmid = 10788465 | doi = 10.1074/jbc.275.18.13510 }}
*{{cite journal | author=Caira F, Antonson P, Pelto-Huikko M, ''et al.'' |title=Cloning and characterization of RAP250, a novel nuclear receptor coactivator. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5308-17 |year= 2000 |pmid= 10681503 |doi= }}
* {{cite journal | vauthors = Ko L, Cardona GR, Chin WW | title = Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 11 | pages = 6212–7 | year = 2000 | pmid = 10823961 | pmc = 18584 | doi = 10.1073/pnas.97.11.6212 }}
*{{cite journal | author=Zhu Y, Kan L, Qi C, ''et al.'' |title=Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13510-6 |year= 2000 |pmid= 10788465 |doi= }}
* {{cite journal | vauthors = Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW | title = Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2 | journal = Mol. Endocrinol. | volume = 14 | issue = 6 | pages = 915–25 | year = 2000 | pmid = 10847592 | doi = 10.1210/mend.14.6.0471 }}
*{{cite journal | author=Ko L, Cardona GR, Chin WW |title=Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 11 |pages= 6212-7 |year= 2000 |pmid= 10823961 |doi= }}
* {{cite journal | vauthors = Mahajan MA, Samuels HH | title = A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein | journal = Mol. Cell. Biol. | volume = 20 | issue = 14 | pages = 5048–63 | year = 2000 | pmid = 10866662 | pmc = 85955 | doi = 10.1128/MCB.20.14.5048-5063.2000 }}
*{{cite journal | author=Lee SK, Na SY, Jung SY, ''et al.'' |title=Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2. |journal=Mol. Endocrinol. |volume=14 |issue= 6 |pages= 915-25 |year= 2000 |pmid= 10847592 |doi= }}
* {{cite journal | vauthors = Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW | title = Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2 | journal = Mol. Endocrinol. | volume = 15 | issue = 2 | pages = 241–54 | year = 2001 | pmid = 11158331 | doi = 10.1210/me.15.2.241 }}
*{{cite journal | author=Mahajan MA, Samuels HH |title=A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 14 |pages= 5048-63 |year= 2000 |pmid= 10866662 |doi= }}
* {{cite journal | vauthors = Hong S, Lee MY, Cheong J | title = Functional interaction of transcriptional coactivator ASC-2 and C/EBPalpha in granulocyte differentiation of HL-60 promyelocytic cell | journal = Biochem. Biophys. Res. Commun. | volume = 282 | issue = 5 | pages = 1257–62 | year = 2001 | pmid = 11302752 | doi = 10.1006/bbrc.2001.4727 }}
*{{cite journal | author=Lee SK, Jung SY, Kim YS, ''et al.'' |title=Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2. |journal=Mol. Endocrinol. |volume=15 |issue= 2 |pages= 241-54 |year= 2001 |pmid= 11158331 |doi= }}
* {{cite journal | vauthors = Iwasaki T, Chin WW, Ko L | title = Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM) | journal = J. Biol. Chem. | volume = 276 | issue = 36 | pages = 33375–83 | year = 2001 | pmid = 11443112 | doi = 10.1074/jbc.M101517200 }}
*{{cite journal | author=Hong S, Lee MY, Cheong J |title=Functional interaction of transcriptional coactivator ASC-2 and C/EBPalpha in granulocyte differentiation of HL-60 promyelocytic cell. |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 5 |pages= 1257-62 |year= 2001 |pmid= 11302752 |doi= 10.1006/bbrc.2001.4727 }}
* {{cite journal | vauthors = Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK | title = Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 18 | pages = 10380–5 | year = 2001 | pmid = 11517327 | pmc = 56969 | doi = 10.1073/pnas.181347498 }}
*{{cite journal | author=Iwasaki T, Chin WW, Ko L |title=Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33375-83 |year= 2001 |pmid= 11443112 |doi= 10.1074/jbc.M101517200 }}
* {{cite journal | vauthors = Jung DJ, Na SY, Na DS, Lee JW | title = Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors | journal = J. Biol. Chem. | volume = 277 | issue = 2 | pages = 1229–34 | year = 2002 | pmid = 11704680 | doi = 10.1074/jbc.M110417200 }}
*{{cite journal | author=Zhu Y, Qi C, Cao WQ, ''et al.'' |title=Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 18 |pages= 10380-5 |year= 2001 |pmid= 11517327 |doi= 10.1073/pnas.181347498 }}
* {{cite journal | vauthors = Ko L, Cardona GR, Iwasaki T, Bramlett KS, Burris TP, Chin WW | title = Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs | journal = Mol. Endocrinol. | volume = 16 | issue = 1 | pages = 128–40 | year = 2002 | pmid = 11773444 | doi = 10.1210/mend.16.1.0755 }}
*{{cite journal | author=Jung DJ, Na SY, Na DS, Lee JW |title=Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors. |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1229-34 |year= 2002 |pmid= 11704680 |doi= 10.1074/jbc.M110417200 }}
* {{cite journal | vauthors = Qi C, Chang J, Zhu Y, Yeldandi AV, Rao SM, Zhu YJ | title = Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha | journal = J. Biol. Chem. | volume = 277 | issue = 32 | pages = 28624–30 | year = 2002 | pmid = 12039952 | doi = 10.1074/jbc.M201053200 }}
*{{cite journal | author=Ko L, Cardona GR, Iwasaki T, ''et al.'' |title=Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs. |journal=Mol. Endocrinol. |volume=16 |issue= 1 |pages= 128-40 |year= 2002 |pmid= 11773444 |doi= }}
* {{cite journal | vauthors = Espejo F, Green M, Preece NE, Assa-Munt N | title = NMR assignment of human ASC2, a self contained protein interaction domain involved in apoptosis and inflammation | journal = J. Biomol. NMR | volume = 23 | issue = 2 | pages = 151–2 | year = 2003 | pmid = 12153040 | doi = 10.1023/A:1016398403157 }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal | author=Qi C, Chang J, Zhu Y, ''et al.'' |title=Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28624-30 |year= 2002 |pmid= 12039952 |doi= 10.1074/jbc.M201053200 }}
*{{cite journal  | author=Espejo F, Green M, Preece NE, Assa-Munt N |title=NMR assignment of human ASC2, a self contained protein interaction domain involved in apoptosis and inflammation. |journal=J. Biomol. NMR |volume=23 |issue= 2 |pages= 151-2 |year= 2003 |pmid= 12153040 |doi=  }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{MeshName|NCOA6+protein,+human}}
* {{MeshName|NCOA6+protein,+human|3=NCOA6 protein, human}}
* {{NURSA|C94}}


{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription coregulators}}
{{Transcription coregulators}}
{{DEFAULTSORT:Ncoa6}}
[[Category:Gene expression]]
[[Category:Gene expression]]
[[Category:Transcription coregulators]]
[[Category:Transcription coregulators]]
{{WikiDoc Sources}}
[[Category:Human proteins]]

Latest revision as of 12:41, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.[1][2][3]

Function

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.[3]

Interactions

NCOA6 has been shown to interact with:

See also

References

  1. ↑ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (November 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
  2. ↑ Estey A, Kemp M, Allison S, Lamb C (January 1994). "Evaluation of a patient information booklet". J Nurs Staff Dev. 9 (6): 278–82. PMID 8263591.
  3. ↑ 3.0 3.1 "Entrez Gene: NCOA6 nuclear receptor coactivator 6".
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (January 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Mol. Cell. Biol. 23 (1): 140–9. doi:10.1128/mcb.23.1.140-149.2003. PMC 140670. PMID 12482968.
  5. ↑ Hong S, Choi HM, Park MJ, Kim YH, Choi YH, Kim HH, Choi YH, Cheong J (April 2004). "Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid". J. Biol. Chem. 279 (17): 16996–7003. doi:10.1074/jbc.M311752200. PMID 14734562.
  6. ↑ 6.0 6.1 Goo YH, Na SY, Zhang H, Xu J, Hong S, Cheong J, Lee SK, Lee JW (February 2004). "Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation". J. Biol. Chem. 279 (8): 7131–5. doi:10.1074/jbc.M312563200. PMID 14645241.
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW (November 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. PMID 10567404.
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW (February 2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. 15 (2): 241–54. doi:10.1210/me.15.2.241. PMID 11158331.
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6212–7. doi:10.1073/pnas.97.11.6212. PMC 18584. PMID 10823961.
  10. ↑ Kong HJ, Yu HJ, Hong S, Park MJ, Choi YH, An WG, Lee JW, Cheong J (November 2003). "Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation". Mol. Cancer Res. 1 (13): 948–58. PMID 14638867.
  11. ↑ 11.0 11.1 11.2 11.3 Ko L, Cardona GR, Iwasaki T, Bramlett KS, Burris TP, Chin WW (January 2002). "Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs". Mol. Endocrinol. 16 (1): 128–40. doi:10.1210/mend.16.1.0755. PMID 11773444.
  12. ↑ 12.0 12.1 Kong HJ, Park MJ, Hong S, Yu HJ, Lee YC, Choi YH, Cheong J (November 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology. 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. PMID 14578865.
  13. ↑ Hong S, Kim SH, Heo MA, Choi YH, Park MJ, Yoo MA, Kim HD, Kang HS, Cheong J (February 2004). "Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock". FEBS Lett. 559 (1–3): 165–70. doi:10.1016/S0014-5793(04)00028-6. PMID 14960326.
  14. ↑ 14.0 14.1 Ko L, Chin WW (March 2003). "Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase". J. Biol. Chem. 278 (13): 11471–9. doi:10.1074/jbc.M209723200. PMID 12519782.
  15. ↑ 15.0 15.1 Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW (June 2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Mol. Endocrinol. 14 (6): 915–25. doi:10.1210/mend.14.6.0471. PMID 10847592.
  16. ↑ Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK (May 2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. 277 (22): 20011–9. doi:10.1074/jbc.M201739200. PMID 11912212.
  17. ↑ Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK (August 2001). "Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10380–5. doi:10.1073/pnas.181347498. PMC 56969. PMID 11517327.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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