NCKIPSD

NCK interacting protein with SH3 domain
Identifiers
Symbols	NCKIPSD ; DIP; DIP1; AF3P21; MGC23891; ORF1; SPIN90; WASLBP; WISH
External IDs	Template:OMIM5 Template:MGI HomoloGene: 9514
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

NCK interacting protein with SH3 domain, also known as NCKIPSD, is a human gene.

The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified.

Further reading

• de Bernard M, Moschioni M, Napolitani G; et al. (2000). "The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein". EMBO J. 19 (1): 48–56. doi:10.1093/emboj/19.1.48. PMID 10619843.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sano K, Hayakawa A, Piao JH; et al. (2000). "Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11) (p21;q23)". Blood. 95 (3): 1066–8. PMID 10648423.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukuoka M, Suetsugu S, Miki H; et al. (2001). "A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42". J. Cell Biol. 152 (3): 471–82. PMID 11157975.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hayakawa A, Matsuda Y, Daibata M; et al. (2001). "Genomic organization, tissue expression, and cellular localization of AF3p21, a fusion partner of MLL in therapy-related leukemia". Genes Chromosomes Cancer. 30 (4): 364–74. doi:10.1002/gcc.1102. PMID 11241789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim CS, Park ES, Kim DJ; et al. (2001). "SPIN90 (SH3 protein interacting with Nck, 90 kDa), an adaptor protein that is developmentally regulated during cardiac myocyte differentiation". J. Biol. Chem. 276 (16): 12871–8. doi:10.1074/jbc.M009411200. PMID 11278500.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Satoh S, Tominaga T (2001). "mDia-interacting protein acts downstream of Rho-mDia and modifies Src activation and stress fiber formation". J. Biol. Chem. 276 (42): 39290–4. doi:10.1074/jbc.M107026200. PMID 11509578.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim CS, Kim SH, Jung JG; et al. (2004). "Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion". J. Biol. Chem. 278 (52): 52116–23. doi:10.1074/jbc.M310974200. PMID 14559906.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim DJ, Kim SH, Lim CS; et al. (2006). "Interaction of SPIN90 with the Arp2/3 complex mediates lamellipodia and actin comet tail formation". J. Biol. Chem. 281 (1): 617–25. doi:10.1074/jbc.M504450200. PMID 16253999.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eisenmann KM, Harris ES, Kitchen SM; et al. (2007). "Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex". Curr. Biol. 17 (7): 579–91. doi:10.1016/j.cub.2007.03.024. PMID 17398099.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rönty M, Taivainen A, Heiska L; et al. (2007). "Palladin interacts with SH3 domains of SPIN90 and Src and is required for Src-induced cytoskeletal remodeling". Exp. Cell Res. 313 (12): 2575–85. doi:10.1016/j.yexcr.2007.04.030. PMID 17537434.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)