Multiple endocrine neoplasia type 2 MRI: Difference between revisions

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Image:Pheochromocytoma CT 3.jpg|Case courtesy of Dr Hani Al Salam, <ref>"http://radiopaedia.org/">Radiopaedia.org</ref>. From the case <ref>"http://radiopaedia.org/cases/8550">rID: 8550</ref>
Image:Pheochromocytoma CT 3.jpg|Image courtesy of Dr Hani Al Salami<ref name=radio01>Image courtesy of Dr Hani Al Salami. [http://www.radiopaedia.org Radiopaedia] (original file[http://radiopaedia.org/cases/8550‘’here’’]).[http://radiopaedia.org/licence Creative Commons BY-SA-NC]</ref>
Image:Pheochromocytoma MRI.jpg|Case courtesy of Dr Frank Gaillard, <ref>"http://radiopaedia.org/">Radiopaedia.org</ref>. From the case <ref>"http://radiopaedia.org/cases/9920">rID: 9920</ref>
[http://radiopaedia.org/licence Creative Commons BY-SA-NC]</ref>
Image:Pheochromocytoma MRI 04.JPG|Case courtesy of Dr G Balachandran, <ref>"http://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="http://radiopaedia.org/cases/10249">rID: 10249</ref>
Image:Pheochromocytoma MRI.jpg|Image courtesy of Dr Frank Gaillard<ref name=radio02>Image courtesy of Dr Frank Gaillard. [http://www.radiopaedia.org Radiopaedia] (original file[http://radiopaedia.org/cases/9920‘’here’’]).[http://radiopaedia.org/licence Creative Commons BY-SA-NC]</ref>
[http://radiopaedia.org/licence Creative Commons BY-SA-NC]</ref>
Image:Pheochromocytoma MRI 04.JPG|Image courtesy of Dr G Balachandran<ref name=radio02>Image courtesy of Dr Frank Gaillard. [http://www.radiopaedia.org Radiopaedia] (original file[http://radiopaedia.org/cases/10249‘’here’’]).[http://radiopaedia.org/licence Creative Commons BY-SA-NC]</ref>
[http://radiopaedia.org/licence Creative Commons BY-SA-NC]</ref>
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==References==
==References==

Revision as of 03:31, 5 October 2015

Multiple endocrine neoplasia type 2 Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [4]

Overview

MRI scan may be helpful in the diagnosis of multiple endocrine neoplasia type 2. Findings on MRI scan suggestive of multiple endocrine neoplasia type 2 include intermediate to low signal at T1 and hyperintense signal at T2 suggesting parathyroid hyperplasia.

MRI

Parathyroid Carcinoma

  • MRI is infrequently utilized in initial work up because of lower spatial resolution and artifacts. Adenomas can show variable signal intensity on MRI. Reported signal characteristics include:
  • T1
  • T2
  • Typically hyperintense
  • Subacute hemorrhage can cause high signal intensity
  • Fibrosis or old hemorrhage can cause low signal intensity
  • Since most lesions demonstrate high T2 signal intensity, the addition of contrast for MR scanning does not significantly increase detection.

Pheochromocytoma

  • MRI is the most sensitive modality for identification of pheochromocytomas, and is particularly useful in cases of extra-adrenal location. The overall sensitivity is said to be 98%.[2]
  • T1
  • Slightly hypointense to the remainder of the adrenal
  • If necrotic and/or hemorrhagic then signal will be more heterogeneous
  • T2
  • Markedly hyperintense (lightbulb sign): this is a helpful feature
  • Areas of necrosis/hemorrhage/calcification will alter signal
  • T1 C+ (Gd)
  • Heterogenous enhancement
  • Enhancement is prolonged, persisting for as long as 50 minutes[3]
  • Image courtesy of Dr Hani Al Salami[4]

    Image courtesy of Dr Hani Al Salami[4]

  • Image courtesy of Dr Frank Gaillard[5]

    Image courtesy of Dr Frank Gaillard[5]

  • Image courtesy of Dr G Balachandran[5]

    Image courtesy of Dr G Balachandran[5]

References

  1. ↑ Johnson NA, Tublin ME, Ogilvie JB (2007). "Parathyroid imaging: technique and role in the preoperative evaluation of primary hyperparathyroidism". AJR Am J Roentgenol. 188 (6): 1706–15. doi:10.2214/AJR.06.0938. PMID 17515397.
  2. ↑ Blake, Michael (2009). Adrenal imaging. Totowa, NJ: Humana Press. ISBN 193411586X.
  3. ↑ Reiser, Maximilian (2008). Magnetic resonance tomography. Berlin: Springer. ISBN 354029354X.
  4. ↑ Image courtesy of Dr Hani Al Salami. Radiopaedia (original file[1]).Creative Commons BY-SA-NC
  5. ↑ 5.0 5.1 Image courtesy of Dr Frank Gaillard. Radiopaedia (original file[2]).Creative Commons BY-SA-NC

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