Multiple endocrine neoplasia type 1 CT: Difference between revisions
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===Gastrointestinal Neuroendocrine Tumors<ref name=Radiopaedia012015>{{cite web | title = Radiopedia2015 Gastrointestinal neuroendocrine tumours [Dr Dalia Ibrahim and Dr Jan Smith]| url = http://radiopaedia.org/articles/gastrointestinal-neuroendocrine-tumours-3 }}</ref>=== | ===Gastrointestinal Neuroendocrine Tumors<ref name=Radiopaedia012015>{{cite web | title = Radiopedia2015 Gastrointestinal neuroendocrine tumours [Dr Dalia Ibrahim and Dr Jan Smith]| url = http://radiopaedia.org/articles/gastrointestinal-neuroendocrine-tumours-3 }}</ref>=== | ||
* CT is used for suspected gastric, enteric and pancreatic [[neuroendocrine tumor]]s with pre and post IV iodinated contrast. | * CT is used for suspected gastric, enteric and pancreatic [[neuroendocrine tumor]]s with pre and post IV iodinated contrast. | ||
* Bowel distension with fluid, either by oral intake (CT enterography) or via an nasojejunal tube (CT enteroclysis), improves detection of primary gastrointestinal neuroendocrine | * [[Bowel]] distension with [[fluid]], either by [[oral]] intake (CT enterography) or via an [[nasojejunal tube]] (CT [[enteroclysis]]), improves detection of primary gastrointestinal [[neuroendocrine tumor]]s . | ||
===Zollinger-Ellison Syndrome<ref name=Radiopaedia022015>{{cite web | title = Radiopedia2015 Zollinger-Ellison syndrome [Dr Henry Knipe]| url = http://radiopaedia.org/articles/zollinger-ellison-syndrome }}</ref>=== | ===Zollinger-Ellison Syndrome<ref name=Radiopaedia022015>{{cite web | title = Radiopedia2015 Zollinger-Ellison syndrome [Dr Henry Knipe]| url = http://radiopaedia.org/articles/zollinger-ellison-syndrome }}</ref>=== | ||
* Negative contrast may be used to distend the stomach | * Negative contrast may be used to distend the [[stomach]] | ||
* Thickened rugal folds | * Thickened rugal folds | ||
* Multiple gastric nodules/masses<ref name="pmid9534694">{{cite journal| author=King AD, Ko GT, Yeung VT, Chow CC, Griffith J, Cockram CS| title=Dual phase spiral CT in the detection of small insulinomas of the pancreas. | journal=Br J Radiol | year= 1998 | volume= 71 | issue= 841 | pages= 20-3 | pmid=9534694 | doi=10.1259/bjr.71.841.9534694 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9534694 }} </ref><ref name="pmid12933480">{{cite journal| author=Fidler JL, Fletcher JG, Reading CC, Andrews JC, Thompson GB, Grant CS et al.| title=Preoperative detection of pancreatic insulinomas on multiphasic helical CT. | journal=AJR Am J Roentgenol | year= 2003 | volume= 181 | issue= 3 | pages= 775-80 | pmid=12933480 | doi=10.2214/ajr.181.3.1810775 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12933480 }} </ref> | * Multiple gastric nodules/masses<ref name="pmid9534694">{{cite journal| author=King AD, Ko GT, Yeung VT, Chow CC, Griffith J, Cockram CS| title=Dual phase spiral CT in the detection of small insulinomas of the pancreas. | journal=Br J Radiol | year= 1998 | volume= 71 | issue= 841 | pages= 20-3 | pmid=9534694 | doi=10.1259/bjr.71.841.9534694 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9534694 }} </ref><ref name="pmid12933480">{{cite journal| author=Fidler JL, Fletcher JG, Reading CC, Andrews JC, Thompson GB, Grant CS et al.| title=Preoperative detection of pancreatic insulinomas on multiphasic helical CT. | journal=AJR Am J Roentgenol | year= 2003 | volume= 181 | issue= 3 | pages= 775-80 | pmid=12933480 | doi=10.2214/ajr.181.3.1810775 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12933480 }} </ref> | ||
===Insulinoma<ref name=Radiopaedia032015>{{cite web | title = Radiopedia2015 Insulinoma [Dr Yuranga Weerakkody and Dr Frank Gaillard]| url = http://radiopaedia.org/articles/insulinoma }}</ref>=== | ===Insulinoma<ref name=Radiopaedia032015>{{cite web | title = Radiopedia2015 Insulinoma [Dr Yuranga Weerakkody and Dr Frank Gaillard]| url = http://radiopaedia.org/articles/insulinoma }}</ref>=== | ||
* They tend to be hyper-attenuating on arterial phase so arterial or pancreatic phased imaging may aid in better detection. Some may show calcification. | * They tend to be hyper-attenuating on arterial phase so arterial or pancreatic phased imaging may aid in better detection. Some may show [[calcification]]. | ||
===Pancreatic Islet Cell Tumors<ref name=Radiopaedia042015>{{cite web | title = Radiopedia2015 Endocrine tumours of the pancreas [Dr Yuranga Weerakkody and Radswiki]| url = http://radiopaedia.org/articles/gastrinoma }}</ref>=== | ===Pancreatic Islet Cell Tumors<ref name=Radiopaedia042015>{{cite web | title = Radiopedia2015 Endocrine tumours of the pancreas [Dr Yuranga Weerakkody and Radswiki]| url = http://radiopaedia.org/articles/gastrinoma }}</ref>=== | ||
* Multiphase contrast enhanced thin slice cross-sectional imaging is ideal. | * Multiphase contrast enhanced thin slice cross-sectional imaging is ideal. [[Tumor]]s tend to be smaller, hypervascular and may be [[calcified]] or cystic. | ||
===Gastrinoma<ref name=Radiopaedia052015>{{cite web | title = Radiopedia2015 Gastrinoma [Dr Frank Gaillard]| url = http://radiopaedia.org/articles/gastrinoma }}</ref>=== | ===Gastrinoma<ref name=Radiopaedia052015>{{cite web | title = Radiopedia2015 Gastrinoma [Dr Frank Gaillard]| url = http://radiopaedia.org/articles/gastrinoma }}</ref>=== | ||
* | * [[Gastinoma]]s are usually [[malignant]] and as they are frequently multiple and often extrapancreatic (90% located in the gastrinoma triangle) they can be difficult to locate. As such multiphase [[contrast]] enhanced thin slice cross-sectional imaging is ideal. | ||
* Tumor size is variable, but the size of pancreatic lesions varies from 3-4 cm. | * [[Tumor]] size is variable, but the size of pancreatic lesions varies from 3-4 cm. | ||
* The | * The [[lesion]]s are often [[hypervascular]], so they may be visible on arterial phase [[CT]] and [[angiography]]. | ||
===Glucagonoma<ref name=Radiopaedia062015>{{cite web | title = Radiopedia2015 Glucagonoma [Dr Yuranga Weerakkody and Dr Frank Gaillard]| url = http://radiopaedia.org/articles/glucagonoma }}</ref>=== | ===Glucagonoma<ref name=Radiopaedia062015>{{cite web | title = Radiopedia2015 Glucagonoma [Dr Yuranga Weerakkody and Dr Frank Gaillard]| url = http://radiopaedia.org/articles/glucagonoma }}</ref>=== | ||
* Tumor size is variable, but most of them are large and have metastasized at the time of diagnosis. Most of them are located in the distal pancreas and are vascular. | * [[Tumor]] size is variable, but most of them are large and have metastasized at the time of diagnosis. Most of them are located in the distal [[pancreas]] and are [[vascular]]. | ||
* | * [[Tumor]]s may be solid or contain central low-attenuation areas on [[CT]]. | ||
==Reference== | ==Reference== | ||
{{Reflist}} | {{Reflist}} | ||
[[Category:Hereditary cancers]] | [[Category:Hereditary cancers]] |
Revision as of 11:30, 11 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Abdominal CT scan may be helpful in the diagnosis of multiple endocrine neoplasia type 1.
CT
Gastrointestinal Neuroendocrine Tumors[1]
- CT is used for suspected gastric, enteric and pancreatic neuroendocrine tumors with pre and post IV iodinated contrast.
- Bowel distension with fluid, either by oral intake (CT enterography) or via an nasojejunal tube (CT enteroclysis), improves detection of primary gastrointestinal neuroendocrine tumors .
Zollinger-Ellison Syndrome[2]
- Negative contrast may be used to distend the stomach
- Thickened rugal folds
- Multiple gastric nodules/masses[3][4]
Insulinoma[5]
- They tend to be hyper-attenuating on arterial phase so arterial or pancreatic phased imaging may aid in better detection. Some may show calcification.
Pancreatic Islet Cell Tumors[6]
- Multiphase contrast enhanced thin slice cross-sectional imaging is ideal. Tumors tend to be smaller, hypervascular and may be calcified or cystic.
Gastrinoma[7]
- Gastinomas are usually malignant and as they are frequently multiple and often extrapancreatic (90% located in the gastrinoma triangle) they can be difficult to locate. As such multiphase contrast enhanced thin slice cross-sectional imaging is ideal.
- Tumor size is variable, but the size of pancreatic lesions varies from 3-4 cm.
- The lesions are often hypervascular, so they may be visible on arterial phase CT and angiography.
Glucagonoma[8]
- Tumor size is variable, but most of them are large and have metastasized at the time of diagnosis. Most of them are located in the distal pancreas and are vascular.
- Tumors may be solid or contain central low-attenuation areas on CT.
Reference
- ↑ "Radiopedia2015 Gastrointestinal neuroendocrine tumours [Dr Dalia Ibrahim and Dr Jan Smith]".
- ↑ "Radiopedia2015 Zollinger-Ellison syndrome [Dr Henry Knipe]".
- ↑ King AD, Ko GT, Yeung VT, Chow CC, Griffith J, Cockram CS (1998). "Dual phase spiral CT in the detection of small insulinomas of the pancreas". Br J Radiol. 71 (841): 20–3. doi:10.1259/bjr.71.841.9534694. PMID 9534694.
- ↑ Fidler JL, Fletcher JG, Reading CC, Andrews JC, Thompson GB, Grant CS; et al. (2003). "Preoperative detection of pancreatic insulinomas on multiphasic helical CT". AJR Am J Roentgenol. 181 (3): 775–80. doi:10.2214/ajr.181.3.1810775. PMID 12933480.
- ↑ "Radiopedia2015 Insulinoma [Dr Yuranga Weerakkody and Dr Frank Gaillard]".
- ↑ "Radiopedia2015 Endocrine tumours of the pancreas [Dr Yuranga Weerakkody and Radswiki]".
- ↑ "Radiopedia2015 Gastrinoma [Dr Frank Gaillard]".
- ↑ "Radiopedia2015 Glucagonoma [Dr Yuranga Weerakkody and Dr Frank Gaillard]".