Monocarboxylate transporter 2
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Monocarboxylate transporter 2 (MCT2) also known as solute carrier family 16 member 7 (SLC16A7) is a protein that in humans is encoded by the SLC16A7 gene.[1] MCT2 is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.
Both Northern blot analysis and inspection of the human expressed sequence tag (EST) database suggest relatively little expression of MCT2 in human tissues. As well, the sequence of MCT2 is far less conserved across species than that of MCT1 or MCT4 and there also appear to be considerable species differences in the tissue expression profile of this isoform.
See also
References
- ↑ Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Apr 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID 8124722.
Further reading
- Pértega-Gomes N, Vizcaíno JR, Gouveia C, Jerónimo C, Henrique RM, Lopes C, Baltazar F (2013). "Monocarboxylate transporter 2 (MCT2) as putative biomarker in prostate cancer". Prostate. 73 (7): 763–9. doi:10.1002/pros.22620. PMID 23192371.
- Lee I, Lee SJ, Kang WK, Park C (2012). "Inhibition of monocarboxylate transporter 2 induces senescence-associated mitochondrial dysfunction and suppresses progression of colorectal malignancies in vivo". Mol. Cancer Ther. 11 (11): 2342–51. doi:10.1158/1535-7163.MCT-12-0488. PMID 22964484.
- Cheng C, Edin NF, Lauritzen KH, Aspmodal I, Christoffersen S, Jian L, Rasmussen LJ, Pettersen EO, Xiaoqun G, Bergersen LH (2012). "Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells". Cell Oncol (Dordr). 35 (3): 217–27. doi:10.1007/s13402-012-0081-9. PMC 3396336. PMID 22700320.
- Lauritzen F, Heuser K, de Lanerolle NC, Lee TS, Spencer DD, Kim JH, Gjedde A, Eid T, Bergersen LH (2012). "Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampus". Glia. 60 (7): 1172–81. doi:10.1002/glia.22344. PMC 3664041. PMID 22535546.
- Halestrap AP (2012). "The monocarboxylate transporter family--Structure and functional characterization". IUBMB Life. 64 (1): 1–9. doi:10.1002/iub.573. PMID 22131303.
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