Monocarboxylate transporter 1: Difference between revisions

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* {{cite journal | vauthors = Ritzhaupt A, Wood IS, Ellis A, Hosie KB, Shirazi-Beechey SP | title = Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate | journal = The Journal of Physiology | volume = 513 | issue = Pt 3 | pages = 719–32 | date = Dec 1998 | pmid = 9824713 | pmc = 2231331 | doi =  10.1111/j.1469-7793.1998.719ba.x}}
* {{cite journal | vauthors = Ritzhaupt A, Wood IS, Ellis A, Hosie KB, Shirazi-Beechey SP | title = Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate | journal = The Journal of Physiology | volume = 513 | issue = Pt 3 | pages = 719–32 | date = Dec 1998 | pmid = 9824713 | pmc = 2231331 | doi =  10.1111/j.1469-7793.1998.719ba.x}}
* {{cite journal | vauthors = Rahman B, Schneider HP, Bröer A, Deitmer JW, Bröer S | title = Helix 8 and helix 10 are involved in substrate recognition in the rat monocarboxylate transporter MCT1 | journal = Biochemistry | volume = 38 | issue = 35 | pages = 11577–84  | date = Aug 1999 | pmid = 10471310 | doi = 10.1021/bi990973f }}
* {{cite journal | vauthors = Rahman B, Schneider HP, Bröer A, Deitmer JW, Bröer S | title = Helix 8 and helix 10 are involved in substrate recognition in the rat monocarboxylate transporter MCT1 | journal = Biochemistry | volume = 38 | issue = 35 | pages = 11577–84  | date = Aug 1999 | pmid = 10471310 | doi = 10.1021/bi990973f }}
* {{cite journal | vauthors = Brooks GA, Brown MA, Butz CE, Sicurello JP, Dubouchaud H | title = Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1 | journal = Journal of Applied Physiology | volume = 87 | issue = 5 | pages = 1713–8  | date = Nov 1999 | pmid = 10562613 | doi =  }}
* {{cite journal | vauthors = Brooks GA, Brown MA, Butz CE, Sicurello JP, Dubouchaud H | title = Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1 | journal = Journal of Applied Physiology | volume = 87 | issue = 5 | pages = 1713–8  | date = Nov 1999 | pmid = 10562613 | doi =  10.1152/jappl.1999.87.5.1713}}
* {{cite journal | vauthors = Merezhinskaya N, Fishbein WN, Davis JI, Foellmer JW | title = Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport | journal = Muscle & Nerve | volume = 23 | issue = 1 | pages = 90–7  | date = Jan 2000 | pmid = 10590411 | doi = 10.1002/(SICI)1097-4598(200001)23:1<90::AID-MUS12>3.0.CO;2-M }}
* {{cite journal | vauthors = Merezhinskaya N, Fishbein WN, Davis JI, Foellmer JW | title = Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport | journal = Muscle & Nerve | volume = 23 | issue = 1 | pages = 90–7  | date = Jan 2000 | pmid = 10590411 | doi = 10.1002/(SICI)1097-4598(200001)23:1<90::AID-MUS12>3.0.CO;2-M | url = https://zenodo.org/record/1235488 }}
* {{cite journal | vauthors = Kirk P, Wilson MC, Heddle C, Brown MH, Barclay AN, Halestrap AP | title = CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression | journal = The EMBO Journal | volume = 19 | issue = 15 | pages = 3896–904  | date = Aug 2000 | pmid = 10921872 | pmc = 306613 | doi = 10.1093/emboj/19.15.3896 }}
* {{cite journal | vauthors = Kirk P, Wilson MC, Heddle C, Brown MH, Barclay AN, Halestrap AP | title = CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression | journal = The EMBO Journal | volume = 19 | issue = 15 | pages = 3896–904  | date = Aug 2000 | pmid = 10921872 | pmc = 306613 | doi = 10.1093/emboj/19.15.3896 }}
* {{cite journal | vauthors = Cuff MA, Lambert DW, Shirazi-Beechey SP | title = Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1 | journal = The Journal of Physiology | volume = 539 | issue = Pt 2 | pages = 361–71  | date = Mar 2002 | pmid = 11882670 | pmc = 2290148 | doi = 10.1113/jphysiol.2001.014241 }}
* {{cite journal | vauthors = Cuff MA, Lambert DW, Shirazi-Beechey SP | title = Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1 | journal = The Journal of Physiology | volume = 539 | issue = Pt 2 | pages = 361–71  | date = Mar 2002 | pmid = 11882670 | pmc = 2290148 | doi = 10.1113/jphysiol.2001.014241 }}
* {{cite journal | vauthors = Cuff MA, Shirazi-Beechey SP | title = The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis | journal = Biochemical and Biophysical Research Communications | volume = 292 | issue = 4 | pages = 1048–56  | date = Apr 2002 | pmid = 11944921 | doi = 10.1006/bbrc.2002.6763 }}
* {{cite journal | vauthors = Cuff MA, Shirazi-Beechey SP | title = The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis | journal = Biochemical and Biophysical Research Communications | volume = 292 | issue = 4 | pages = 1048–56  | date = Apr 2002 | pmid = 11944921 | doi = 10.1006/bbrc.2002.6763 }}
* {{cite journal | vauthors = Lambert DW, Wood IS, Ellis A, Shirazi-Beechey SP | title = Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy | journal = British Journal of Cancer | volume = 86 | issue = 8 | pages = 1262–9  | date = Apr 2002 | pmid = 11953883 | pmc = 2375337 | doi = 10.1038/sj.bjc.6600264 }}
* {{cite journal | vauthors = Lambert DW, Wood IS, Ellis A, Shirazi-Beechey SP | title = Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy | journal = British Journal of Cancer | volume = 86 | issue = 8 | pages = 1262–9  | date = Apr 2002 | pmid = 11953883 | pmc = 2375337 | doi = 10.1038/sj.bjc.6600264 }}
* {{cite journal | vauthors = Zhang GZ, Huang GJ, Li WL, Wu GM, Qian GS | title = [Effect of co-inhibition of MCT1 gene and NHE1 gene on proliferation and growth of human lung adenocarcinoma cells] | journal = Ai Zheng = Aizheng = Chinese Journal of Cancer | volume = 21 | issue = 7 | pages = 719–23  | date = Jul 2002 | pmid = 12479094 | doi =  }}
* {{cite journal | vauthors = Zhang GZ, Huang GJ, Li WL, Wu GM, Qian GS | title = [Effect of co-inhibition of MCT1 gene and NHE1 gene on proliferation and growth of human lung adenocarcinoma cells] | journal = AI Zheng = Aizheng = Chinese Journal of Cancer | volume = 21 | issue = 7 | pages = 719–23  | date = Jul 2002 | pmid = 12479094 | doi =  }}
* {{cite journal | vauthors = Philp NJ, Wang D, Yoon H, Hjelmeland LM | title = Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells | journal = Investigative Ophthalmology & Visual Science | volume = 44 | issue = 4 | pages = 1716–21  | date = Apr 2003 | pmid = 12657613 | doi = 10.1167/iovs.02-0287 }}
* {{cite journal | vauthors = Philp NJ, Wang D, Yoon H, Hjelmeland LM | title = Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells | journal = Investigative Ophthalmology & Visual Science | volume = 44 | issue = 4 | pages = 1716–21  | date = Apr 2003 | pmid = 12657613 | doi = 10.1167/iovs.02-0287 }}
* {{cite journal | vauthors = Asada K, Miyamoto K, Fukutomi T, Tsuda H, Yagi Y, Wakazono K, Oishi S, Fukui H, Sugimura T, Ushijima T | title = Reduced expression of GNA11 and silencing of MCT1 in human breast cancers | journal = Oncology | volume = 64 | issue = 4 | pages = 380–8 | year = 2003 | pmid = 12759536 | doi = 10.1159/000070297 }}
* {{cite journal | vauthors = Asada K, Miyamoto K, Fukutomi T, Tsuda H, Yagi Y, Wakazono K, Oishi S, Fukui H, Sugimura T, Ushijima T | title = Reduced expression of GNA11 and silencing of MCT1 in human breast cancers | journal = Oncology | volume = 64 | issue = 4 | pages = 380–8 | year = 2003 | pmid = 12759536 | doi = 10.1159/000070297 }}

Latest revision as of 09:51, 25 October 2018

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Orthologs
SpeciesHumanMouse
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Monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC16A1 gene (also known as MCT1).[1][2][3] It is a proton coupled monocarboxylate transporter.

Biochemistry

Detailed kinetic analysis of monocarboxylate transport in erythrocytes revealed that MCT1 operates through an ordered mechanism. MCT1 has a substrate binding site open to the extracellular matrix which binds a proton first followed by the lactate anion. The protein then undergoes a conformational change to a new ‘closed’’ conformation that exposes both the proton and lactate to the opposite surface of the membrane where they are released, lactate first and then the proton. For net transport of lactic acid, the rate-limiting step is the return of MCT1 without bound substrate to the open conformation. For this reason, exchange of one monocarboxylate inside the cell with another outside is considerably faster than net transport of a monocarboxylate across the membrane.

Animal studies

Overexpression of MCT1 has been shown to increase the efficacy of an anti-cancer drug currently undergoing clinical trials called 3-bromopyruvate in breast cancer cells.[4]

Clinical significance

Most cases of alveolar soft part sarcoma show PAS(+), diastase-resistant (PAS-D (+)) intracytoplasmic crystals which contain CD147 and monocarboxylate transporter 1 (MCT1).[5] Overexpression of MCT1 in pancreatic beta cells leads to hyperinsulinism during exercise.[6]

See also

References

  1. ↑ Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Mar 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID 8124722.
  2. ↑ Garcia CK, Li X, Luna J, Francke U (Sep 1994). "cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12". Genomics. 23 (2): 500–3. doi:10.1006/geno.1994.1532. PMID 7835905.
  3. ↑ "Entrez Gene: SLC16A1 solute carrier family 16, member 1 (monocarboxylic acid transporter 1)".
  4. ↑ Liu Z, Sun Y, Hong H, Zhao S, Zou X, Ma R, Jiang C, Wang Z, Li H, Liu H (2015-08-15). "3-bromopyruvate enhanced daunorubicin-induced cytotoxicity involved in monocarboxylate transporter 1 in breast cancer cells". American Journal of Cancer Research. 5 (9): 2673–85. PMC 4633897. PMID 26609475.
  5. ↑ Ladanyi M, Antonescu CR, Drobnjak M, Baren A, Lui MY, Golde DW, Cordon-Cardo C (Apr 2002). "The precrystalline cytoplasmic granules of alveolar soft part sarcoma contain monocarboxylate transporter 1 and CD147". The American Journal of Pathology. 160 (4): 1215–21. doi:10.1016/S0002-9440(10)62548-5. PMC 1867200. PMID 11943706.
  6. ↑ Pullen TJ, Sylow L, Sun G, Halestrap AP, Richter EA, Rutter GA (Jul 2012). "Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic β-cells leads to relative hyperinsulinism during exercise". Diabetes. 61 (7): 1719–25. doi:10.2337/db11-1531. PMC 3379650. PMID 22522610.

Further reading


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