Mixed connective tissue disease natural history, complications and prognosis: Difference between revisions
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===Natural History=== | ===Natural History=== | ||
* If left untreated, approximately 35% of patients with mixed connective tissue disease may progress to develop lung fibrosis.<ref name="pmid22550317">{{cite journal| author=Gunnarsson R, Aaløkken TM, Molberg Ø, Lund MB, Mynarek GK, Lexberg AS et al.| title=Prevalence and severity of interstitial lung disease in mixed connective tissue disease: a nationwide, cross-sectional study. | journal=Ann Rheum Dis | year= 2012 | volume= 71 | issue= 12 | pages= 1966-72 | pmid=22550317 | doi=10.1136/annrheumdis-2011-201253 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22550317 }}</ref> | |||
===Complications=== | ===Complications=== | ||
*Common complications of MCTD include:<ref name="pmid24461387">{{cite journal |vauthors=Tani C, Carli L, Vagnani S, Talarico R, Baldini C, Mosca M, Bombardieri S |title=The diagnosis and classification of mixed connective tissue disease |journal=J. Autoimmun. |volume=48-49 |issue= |pages=46–9 |date=2014 |pmid=24461387 |doi=10.1016/j.jaut.2014.01.008 |url=}}</ref><ref name="pmid27453743">{{cite journal |vauthors=Nica AE, Alexa LM, Ionescu AO, Andronic O, Păduraru DN |title=Esophageal disorders in mixed connective tissue diseases |journal=J Med Life |volume=9 |issue=2 |pages=141–3 |date=2016 |pmid=27453743 |pmc=4863503 |doi= |url=}}</ref><ref name="pmid15716315">{{cite journal |vauthors=Bodolay E, Szekanecz Z, Dévényi K, Galuska L, Csípo I, Vègh J, Garai I, Szegedi G |title=Evaluation of interstitial lung disease in mixed connective tissue disease (MCTD) |journal=Rheumatology (Oxford) |volume=44 |issue=5 |pages=656–61 |date=May 2005 |pmid=15716315 |doi=10.1093/rheumatology/keh575 |url=}}</ref> | *Common complications of MCTD include:<ref name="pmid24461387">{{cite journal |vauthors=Tani C, Carli L, Vagnani S, Talarico R, Baldini C, Mosca M, Bombardieri S |title=The diagnosis and classification of mixed connective tissue disease |journal=J. Autoimmun. |volume=48-49 |issue= |pages=46–9 |date=2014 |pmid=24461387 |doi=10.1016/j.jaut.2014.01.008 |url=}}</ref><ref name="pmid27453743">{{cite journal |vauthors=Nica AE, Alexa LM, Ionescu AO, Andronic O, Păduraru DN |title=Esophageal disorders in mixed connective tissue diseases |journal=J Med Life |volume=9 |issue=2 |pages=141–3 |date=2016 |pmid=27453743 |pmc=4863503 |doi= |url=}}</ref><ref name="pmid15716315">{{cite journal |vauthors=Bodolay E, Szekanecz Z, Dévényi K, Galuska L, Csípo I, Vègh J, Garai I, Szegedi G |title=Evaluation of interstitial lung disease in mixed connective tissue disease (MCTD) |journal=Rheumatology (Oxford) |volume=44 |issue=5 |pages=656–61 |date=May 2005 |pmid=15716315 |doi=10.1093/rheumatology/keh575 |url=}}</ref> |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
Natural History, Complications, and Prognosis
Natural History
- If left untreated, approximately 35% of patients with mixed connective tissue disease may progress to develop lung fibrosis.[1]
Complications
- Common complications of MCTD include:[2][3][4]
- Polyarthritis
- Raynaud's phenomenon
- Puffy fingers (sausage digits)
- Interstitial lung disease
- Esophageal dysmotility
- Sclerodactyly
- Polymyositis
- Pulmonary hypertension
Prognosis
- In MCTD, prognosis depends on the type of organ involvement.[5]
- Major causes of morbidity in long-term MCTD patients include:[6]
- The worst prognosis and high mortality rate are associated with the presence of pulmonary involvement.[7]
References
- ↑ Gunnarsson R, Aaløkken TM, Molberg Ø, Lund MB, Mynarek GK, Lexberg AS; et al. (2012). "Prevalence and severity of interstitial lung disease in mixed connective tissue disease: a nationwide, cross-sectional study". Ann Rheum Dis. 71 (12): 1966–72. doi:10.1136/annrheumdis-2011-201253. PMID 22550317.
- ↑ Tani C, Carli L, Vagnani S, Talarico R, Baldini C, Mosca M, Bombardieri S (2014). "The diagnosis and classification of mixed connective tissue disease". J. Autoimmun. 48-49: 46–9. doi:10.1016/j.jaut.2014.01.008. PMID 24461387.
- ↑ Nica AE, Alexa LM, Ionescu AO, Andronic O, Păduraru DN (2016). "Esophageal disorders in mixed connective tissue diseases". J Med Life. 9 (2): 141–3. PMC 4863503. PMID 27453743.
- ↑ Bodolay E, Szekanecz Z, Dévényi K, Galuska L, Csípo I, Vègh J, Garai I, Szegedi G (May 2005). "Evaluation of interstitial lung disease in mixed connective tissue disease (MCTD)". Rheumatology (Oxford). 44 (5): 656–61. doi:10.1093/rheumatology/keh575. PMID 15716315.
- ↑ Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E (October 2013). "Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl". Postepy Dermatol Alergol. 30 (5): 329–36. doi:10.5114/pdia.2013.38365. PMC 3858664. PMID 24353496.
- ↑ Ciang NC, Pereira N, Isenberg DA (March 2017). "Mixed connective tissue disease-enigma variations?". Rheumatology (Oxford). 56 (3): 326–333. doi:10.1093/rheumatology/kew265. PMID 27436003.
- ↑ Ortega-Hernandez OD, Shoenfeld Y (February 2012). "Mixed connective tissue disease: an overview of clinical manifestations, diagnosis and treatment". Best Pract Res Clin Rheumatol. 26 (1): 61–72. doi:10.1016/j.berh.2012.01.009. PMID 22424193.