Mixed connective tissue disease diagnostic study of choice
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Differentiating Mixed connective tissue disease from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
The diagnostic criteria of Kasukawa include symptoms common to all the diseases involved, presence of antibodies against the U1snRNP, and selected symptoms typical of each of the particular component diseases separately (systemic lupus erythematosus, systemic sclerosis, polymyositis). The diagnosis of MCTD can be confirmed by at least one common symptom, positive antibodies against U1RNP, and at least one symptom from each of the component diseases.
Diagnostic Criteria
- The diagnostic criteria of Kasukawa is the most widely used criteria for MCTD. They are considered to be the most precise and include:[1][2]
- Symptoms common to all the diseases involved (such as Raynaud’s phenomenon or swollen fingers)
- Antibodies against U1snRNP
- Selected symptoms typical of each of the particular component diseases separately (systemic lupus erythematosus, systemic sclerosis, polymyositis)
- The diagnosis of MCTD can be confirmed by:
- At least one common symptom
- Positive antibodies against U1RNP
- At least one symptom from each of the component diseases
References
- ↑ Tani C, Carli L, Vagnani S, Talarico R, Baldini C, Mosca M, Bombardieri S (2014). "The diagnosis and classification of mixed connective tissue disease". J. Autoimmun. 48-49: 46–9. doi:10.1016/j.jaut.2014.01.008. PMID 24461387.
- ↑ Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E (October 2013). "Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl". Postepy Dermatol Alergol. 30 (5): 329–36. doi:10.5114/pdia.2013.38365. PMC 3858664. PMID 24353496.