Mixed connective tissue disease natural history, complications and prognosis: Difference between revisions
Jump to navigation
Jump to search
| Line 8: | Line 8: | ||
===Natural History=== | ===Natural History=== | ||
===Complications=== | ===Complications=== | ||
*Common complications of MCTD include:<ref name="pmid24461387">{{cite journal |vauthors=Tani C, Carli L, Vagnani S, Talarico R, Baldini C, Mosca M, Bombardieri S |title=The diagnosis and classification of mixed connective tissue disease |journal=J. Autoimmun. |volume=48-49 |issue= |pages=46–9 |date=2014 |pmid=24461387 |doi=10.1016/j.jaut.2014.01.008 |url=}}</ref><ref name="pmid27453743">{{cite journal |vauthors=Nica AE, Alexa LM, Ionescu AO, Andronic O, Păduraru DN |title=Esophageal disorders in mixed connective tissue diseases |journal=J Med Life |volume=9 |issue=2 |pages=141–3 |date=2016 |pmid=27453743 |pmc=4863503 |doi= |url=}}</ref><ref name="pmid15716315">{{cite journal |vauthors=Bodolay E, Szekanecz Z, Dévényi K, Galuska L, Csípo I, Vègh J, Garai I, Szegedi G |title=Evaluation of interstitial lung disease in mixed connective tissue disease (MCTD) |journal=Rheumatology (Oxford) |volume=44 |issue=5 |pages=656–61 |date=May 2005 |pmid=15716315 |doi=10.1093/rheumatology/keh575 |url=}}</ref> | *Common complications of MCTD include:<ref name="pmid24461387">{{cite journal |vauthors=Tani C, Carli L, Vagnani S, Talarico R, Baldini C, Mosca M, Bombardieri S |title=The diagnosis and classification of mixed connective tissue disease |journal=J. Autoimmun. |volume=48-49 |issue= |pages=46–9 |date=2014 |pmid=24461387 |doi=10.1016/j.jaut.2014.01.008 |url=}}</ref><ref name="pmid27453743">{{cite journal |vauthors=Nica AE, Alexa LM, Ionescu AO, Andronic O, Păduraru DN |title=Esophageal disorders in mixed connective tissue diseases |journal=J Med Life |volume=9 |issue=2 |pages=141–3 |date=2016 |pmid=27453743 |pmc=4863503 |doi= |url=}}</ref><ref name="pmid15716315">{{cite journal |vauthors=Bodolay E, Szekanecz Z, Dévényi K, Galuska L, Csípo I, Vègh J, Garai I, Szegedi G |title=Evaluation of interstitial lung disease in mixed connective tissue disease (MCTD) |journal=Rheumatology (Oxford) |volume=44 |issue=5 |pages=656–61 |date=May 2005 |pmid=15716315 |doi=10.1093/rheumatology/keh575 |url=}}</ref> | ||
**Polyarthritis | **[[Polyarthritis]] | ||
**Raynaud's phenomenon | **[[Raynaud's phenomenon]] | ||
**Puffy fingers (sausage digits) | **Puffy fingers (sausage digits) | ||
**Interstitial lung disease | **[[Interstitial lung disease]] | ||
**Esophageal dysmotility | **[[Esophageal motility disorder|Esophageal dysmotility]] | ||
**Sclerodactyly | **[[Sclerodactyly]] | ||
**Polymyositis | **[[Polymyositis]] | ||
**Pulmonary hypertension | **[[Pulmonary hypertension]] | ||
===Prognosis=== | ===Prognosis=== | ||
*In MCTD, prognosis depends on the type of organ involvement.<ref name="pmid24353496">{{cite journal |vauthors=Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E |title=Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl |journal=Postepy Dermatol Alergol |volume=30 |issue=5 |pages=329–36 |date=October 2013 |pmid=24353496 |pmc=3858664 |doi=10.5114/pdia.2013.38365 |url=}}</ref> | *In MCTD, [[prognosis]] depends on the type of organ involvement.<ref name="pmid24353496">{{cite journal |vauthors=Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E |title=Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl |journal=Postepy Dermatol Alergol |volume=30 |issue=5 |pages=329–36 |date=October 2013 |pmid=24353496 |pmc=3858664 |doi=10.5114/pdia.2013.38365 |url=}}</ref> | ||
*Major causes of morbidity in long-term MCTD patients include:<ref name="pmid27436003">{{cite journal |vauthors=Ciang NC, Pereira N, Isenberg DA |title=Mixed connective tissue disease-enigma variations? |journal=Rheumatology (Oxford) |volume=56 |issue=3 |pages=326–333 |date=March 2017 |pmid=27436003 |doi=10.1093/rheumatology/kew265 |url=}}</ref> | *Major causes of [[morbidity]] in long-term MCTD patients include:<ref name="pmid27436003">{{cite journal |vauthors=Ciang NC, Pereira N, Isenberg DA |title=Mixed connective tissue disease-enigma variations? |journal=Rheumatology (Oxford) |volume=56 |issue=3 |pages=326–333 |date=March 2017 |pmid=27436003 |doi=10.1093/rheumatology/kew265 |url=}}</ref> | ||
**Sclerodactyly | **[[Sclerodactyly]] | ||
**Diffuse sclerosis | **Diffuse [[sclerosis]] | ||
**Pulmonary arterial hypertension | **[[Pulmonary hypertension|Pulmonary arterial hypertension]] | ||
**Nervous system disease | **[[Nervous system disease]] | ||
*The worst prognosis and high mortality rate are associated with the presence of pulmonary involvement.<ref name="pmid22424193">{{cite journal |vauthors=Ortega-Hernandez OD, Shoenfeld Y |title=Mixed connective tissue disease: an overview of clinical manifestations, diagnosis and treatment |journal=Best Pract Res Clin Rheumatol |volume=26 |issue=1 |pages=61–72 |date=February 2012 |pmid=22424193 |doi=10.1016/j.berh.2012.01.009 |url=}}</ref> | *The worst [[prognosis]] and high [[mortality rate]] are associated with the presence of pulmonary involvement.<ref name="pmid22424193">{{cite journal |vauthors=Ortega-Hernandez OD, Shoenfeld Y |title=Mixed connective tissue disease: an overview of clinical manifestations, diagnosis and treatment |journal=Best Pract Res Clin Rheumatol |volume=26 |issue=1 |pages=61–72 |date=February 2012 |pmid=22424193 |doi=10.1016/j.berh.2012.01.009 |url=}}</ref> | ||
==References== | ==References== | ||
Revision as of 14:23, 12 April 2018
|
Mixed connective tissue disease Microchapters |
|
Differentiating Mixed connective tissue disease from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Mixed connective tissue disease natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Mixed connective tissue disease natural history, complications and prognosis |
|
FDA on Mixed connective tissue disease natural history, complications and prognosis |
|
on Mixed connective tissue disease natural history, complications and prognosis |
|
Mixed connective tissue disease natural history, complications and prognosis in the news |
|
Blogs onMixed connective tissue disease natural history, complications and prognosis |
|
Directions to Hospitals Treating Mixed connective tissue disease |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
Natural History, Complications, and Prognosis
Natural History
Complications
- Common complications of MCTD include:[1][2][3]
- Polyarthritis
- Raynaud's phenomenon
- Puffy fingers (sausage digits)
- Interstitial lung disease
- Esophageal dysmotility
- Sclerodactyly
- Polymyositis
- Pulmonary hypertension
Prognosis
- In MCTD, prognosis depends on the type of organ involvement.[4]
- Major causes of morbidity in long-term MCTD patients include:[5]
- The worst prognosis and high mortality rate are associated with the presence of pulmonary involvement.[6]
References
- ↑ Tani C, Carli L, Vagnani S, Talarico R, Baldini C, Mosca M, Bombardieri S (2014). "The diagnosis and classification of mixed connective tissue disease". J. Autoimmun. 48-49: 46–9. doi:10.1016/j.jaut.2014.01.008. PMID 24461387.
- ↑ Nica AE, Alexa LM, Ionescu AO, Andronic O, Păduraru DN (2016). "Esophageal disorders in mixed connective tissue diseases". J Med Life. 9 (2): 141–3. PMC 4863503. PMID 27453743.
- ↑ Bodolay E, Szekanecz Z, Dévényi K, Galuska L, Csípo I, Vègh J, Garai I, Szegedi G (May 2005). "Evaluation of interstitial lung disease in mixed connective tissue disease (MCTD)". Rheumatology (Oxford). 44 (5): 656–61. doi:10.1093/rheumatology/keh575. PMID 15716315.
- ↑ Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E (October 2013). "Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl". Postepy Dermatol Alergol. 30 (5): 329–36. doi:10.5114/pdia.2013.38365. PMC 3858664. PMID 24353496.
- ↑ Ciang NC, Pereira N, Isenberg DA (March 2017). "Mixed connective tissue disease-enigma variations?". Rheumatology (Oxford). 56 (3): 326–333. doi:10.1093/rheumatology/kew265. PMID 27436003.
- ↑ Ortega-Hernandez OD, Shoenfeld Y (February 2012). "Mixed connective tissue disease: an overview of clinical manifestations, diagnosis and treatment". Best Pract Res Clin Rheumatol. 26 (1): 61–72. doi:10.1016/j.berh.2012.01.009. PMID 22424193.