Mixed connective tissue disease natural history, complications and prognosis: Difference between revisions
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===Prognosis=== | ===Prognosis=== | ||
*In MCTD, prognosis depends on the type of organ involvement.<ref name="pmid24353496">{{cite journal |vauthors=Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E |title=Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl |journal=Postepy Dermatol Alergol |volume=30 |issue=5 |pages=329–36 |date=October 2013 |pmid=24353496 |pmc=3858664 |doi=10.5114/pdia.2013.38365 |url=}}</ref> | *In MCTD, prognosis depends on the type of organ involvement.<ref name="pmid24353496">{{cite journal |vauthors=Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E |title=Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl |journal=Postepy Dermatol Alergol |volume=30 |issue=5 |pages=329–36 |date=October 2013 |pmid=24353496 |pmc=3858664 |doi=10.5114/pdia.2013.38365 |url=}}</ref> | ||
*Major causes of morbidity in long-term MCTD patients include:<ref name="pmid27436003">{{cite journal |vauthors=Ciang NC, Pereira N, Isenberg DA |title=Mixed connective tissue disease-enigma variations? |journal=Rheumatology (Oxford) |volume=56 |issue=3 |pages=326–333 |date=March 2017 |pmid=27436003 |doi=10.1093/rheumatology/kew265 |url=}}</ref> | |||
**Sclerodactyly | |||
**Diffuse sclerosis | |||
**Pulmonary arterial hypertension | |||
**Nervous system disease | |||
*The worst prognosis and high mortality rate are associated with the presence of pulmonary involvement.<ref name="pmid22424193">{{cite journal |vauthors=Ortega-Hernandez OD, Shoenfeld Y |title=Mixed connective tissue disease: an overview of clinical manifestations, diagnosis and treatment |journal=Best Pract Res Clin Rheumatol |volume=26 |issue=1 |pages=61–72 |date=February 2012 |pmid=22424193 |doi=10.1016/j.berh.2012.01.009 |url=}}</ref> | *The worst prognosis and high mortality rate are associated with the presence of pulmonary involvement.<ref name="pmid22424193">{{cite journal |vauthors=Ortega-Hernandez OD, Shoenfeld Y |title=Mixed connective tissue disease: an overview of clinical manifestations, diagnosis and treatment |journal=Best Pract Res Clin Rheumatol |volume=26 |issue=1 |pages=61–72 |date=February 2012 |pmid=22424193 |doi=10.1016/j.berh.2012.01.009 |url=}}</ref> | ||
Revision as of 21:07, 10 April 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
Natural History, Complications, and Prognosis
Natural History
- The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
- The symptoms of (disease name) typically develop ___ years after exposure to ___.
- If left untreated, % of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
Complications
- Common complications of MCTD include:[1][2]
- Polyarthritis
- Raynaud's phenomenon
- Puffy fingers (sausage digits)
- Interstitial lung disease
- Esophageal dysmotility
- Sclerodactyly
- Polymyositis
Prognosis
- In MCTD, prognosis depends on the type of organ involvement.[3]
- Major causes of morbidity in long-term MCTD patients include:[4]
- Sclerodactyly
- Diffuse sclerosis
- Pulmonary arterial hypertension
- Nervous system disease
- The worst prognosis and high mortality rate are associated with the presence of pulmonary involvement.[5]
References
- ↑ Tani C, Carli L, Vagnani S, Talarico R, Baldini C, Mosca M, Bombardieri S (2014). "The diagnosis and classification of mixed connective tissue disease". J. Autoimmun. 48-49: 46–9. doi:10.1016/j.jaut.2014.01.008. PMID 24461387.
- ↑ Nica AE, Alexa LM, Ionescu AO, Andronic O, Păduraru DN (2016). "Esophageal disorders in mixed connective tissue diseases". J Med Life. 9 (2): 141–3. PMC 4863503. PMID 27453743.
- ↑ Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E (October 2013). "Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl". Postepy Dermatol Alergol. 30 (5): 329–36. doi:10.5114/pdia.2013.38365. PMC 3858664. PMID 24353496.
- ↑ Ciang NC, Pereira N, Isenberg DA (March 2017). "Mixed connective tissue disease-enigma variations?". Rheumatology (Oxford). 56 (3): 326–333. doi:10.1093/rheumatology/kew265. PMID 27436003.
- ↑ Ortega-Hernandez OD, Shoenfeld Y (February 2012). "Mixed connective tissue disease: an overview of clinical manifestations, diagnosis and treatment". Best Pract Res Clin Rheumatol. 26 (1): 61–72. doi:10.1016/j.berh.2012.01.009. PMID 22424193.