Mixed connective tissue disease natural history, complications and prognosis: Difference between revisions
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===Complications=== | ===Complications=== | ||
*Common complications of MCTD include:<ref name="pmid24461387">{{cite journal |vauthors=Tani C, Carli L, Vagnani S, Talarico R, Baldini C, Mosca M, Bombardieri S |title=The diagnosis and classification of mixed connective tissue disease |journal=J. Autoimmun. |volume=48-49 |issue= |pages=46–9 |date=2014 |pmid=24461387 |doi=10.1016/j.jaut.2014.01.008 |url=}}</ref> | *Common complications of MCTD include:<ref name="pmid24461387">{{cite journal |vauthors=Tani C, Carli L, Vagnani S, Talarico R, Baldini C, Mosca M, Bombardieri S |title=The diagnosis and classification of mixed connective tissue disease |journal=J. Autoimmun. |volume=48-49 |issue= |pages=46–9 |date=2014 |pmid=24461387 |doi=10.1016/j.jaut.2014.01.008 |url=}}</ref><ref name="pmid27453743">{{cite journal |vauthors=Nica AE, Alexa LM, Ionescu AO, Andronic O, Păduraru DN |title=Esophageal disorders in mixed connective tissue diseases |journal=J Med Life |volume=9 |issue=2 |pages=141–3 |date=2016 |pmid=27453743 |pmc=4863503 |doi= |url=}}</ref> | ||
**Polyarthritis | **Polyarthritis | ||
**Raynaud's phenomenon | **Raynaud's phenomenon | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
Natural History, Complications, and Prognosis
Natural History
- The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
- The symptoms of (disease name) typically develop ___ years after exposure to ___.
- If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
Complications
- Common complications of MCTD include:[1][2]
- Polyarthritis
- Raynaud's phenomenon
- Puffy fingers
- Interstitial lung disease
- Esophageal dysmotility
- Sclerodactyly
- Polymyositis
Prognosis
- In MCTD, the worst prognosis and high mortality rate are associated with the presence of pulmonary involvement.[3]
References
- ↑ Tani C, Carli L, Vagnani S, Talarico R, Baldini C, Mosca M, Bombardieri S (2014). "The diagnosis and classification of mixed connective tissue disease". J. Autoimmun. 48-49: 46–9. doi:10.1016/j.jaut.2014.01.008. PMID 24461387.
- ↑ Nica AE, Alexa LM, Ionescu AO, Andronic O, Păduraru DN (2016). "Esophageal disorders in mixed connective tissue diseases". J Med Life. 9 (2): 141–3. PMC 4863503. PMID 27453743.
- ↑ Ortega-Hernandez OD, Shoenfeld Y (February 2012). "Mixed connective tissue disease: an overview of clinical manifestations, diagnosis and treatment". Best Pract Res Clin Rheumatol. 26 (1): 61–72. doi:10.1016/j.berh.2012.01.009. PMID 22424193.